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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DAB1
Full Name:
Disabled homolog 1
Alias:
Disabled 1
Type:
Adapter/scaffold protein
Mass (Da):
63775
Number AA:
588
UniProt ID:
O75553
International Prot ID:
IPI00026889
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S27
R
K
K
G
Q
D
R
S
E
A
T
L
I
K
R
Site 2
Y42
F
K
G
E
G
V
R
Y
K
A
K
L
I
G
I
Site 3
T101
I
K
I
F
D
E
K
T
G
A
L
Q
H
H
H
Site 4
T121
S
Y
I
A
K
D
I
T
D
H
R
A
F
G
Y
Site 5
Y128
T
D
H
R
A
F
G
Y
V
C
G
K
E
G
N
Site 6
Y162
R
D
L
F
Q
L
I
Y
E
L
K
Q
R
E
E
Site 7
Y185
K
Q
C
E
Q
A
V
Y
Q
T
I
L
E
E
D
Site 8
Y198
E
D
V
E
D
P
V
Y
Q
Y
I
V
F
E
A
Site 9
Y200
V
E
D
P
V
Y
Q
Y
I
V
F
E
A
G
H
Site 10
T215
E
P
I
R
D
P
E
T
E
E
N
I
Y
Q
V
Site 11
Y220
P
E
T
E
E
N
I
Y
Q
V
P
T
S
Q
K
Site 12
S225
N
I
Y
Q
V
P
T
S
Q
K
K
E
G
V
Y
Site 13
Y232
S
Q
K
K
E
G
V
Y
D
V
P
K
S
Q
P
Site 14
S237
G
V
Y
D
V
P
K
S
Q
P
V
S
N
G
Y
Site 15
S241
V
P
K
S
Q
P
V
S
N
G
Y
S
F
E
D
Site 16
S245
Q
P
V
S
N
G
Y
S
F
E
D
F
E
E
R
Site 17
T257
E
E
R
F
A
A
A
T
P
N
R
N
L
P
T
Site 18
S286
L
E
L
F
G
D
M
S
T
P
P
D
I
T
S
Site 19
T287
E
L
F
G
D
M
S
T
P
P
D
I
T
S
P
Site 20
T292
M
S
T
P
P
D
I
T
S
P
P
T
P
A
T
Site 21
S293
S
T
P
P
D
I
T
S
P
P
T
P
A
T
P
Site 22
T296
P
D
I
T
S
P
P
T
P
A
T
P
G
D
A
Site 23
T299
T
S
P
P
T
P
A
T
P
G
D
A
F
I
P
Site 24
S307
P
G
D
A
F
I
P
S
S
S
Q
T
L
P
A
Site 25
S308
G
D
A
F
I
P
S
S
S
Q
T
L
P
A
S
Site 26
S309
D
A
F
I
P
S
S
S
Q
T
L
P
A
S
A
Site 27
T383
Q
P
G
L
F
P
A
T
Q
Q
P
W
P
T
V
Site 28
T389
A
T
Q
Q
P
W
P
T
V
A
G
Q
F
P
P
Site 29
T418
A
M
F
Q
G
P
L
T
P
L
A
T
V
P
G
Site 30
T422
G
P
L
T
P
L
A
T
V
P
G
T
S
D
S
Site 31
T426
P
L
A
T
V
P
G
T
S
D
S
T
R
S
S
Site 32
S427
L
A
T
V
P
G
T
S
D
S
T
R
S
S
P
Site 33
S429
T
V
P
G
T
S
D
S
T
R
S
S
P
Q
T
Site 34
S433
T
S
D
S
T
R
S
S
P
Q
T
D
K
P
R
Site 35
T436
S
T
R
S
S
P
Q
T
D
K
P
R
Q
K
M
Site 36
T447
R
Q
K
M
G
K
E
T
F
K
D
F
Q
M
A
Site 37
S461
A
Q
P
P
P
V
P
S
R
K
P
D
Q
P
S
Site 38
S468
S
R
K
P
D
Q
P
S
L
T
C
T
S
E
A
Site 39
T470
K
P
D
Q
P
S
L
T
C
T
S
E
A
F
S
Site 40
T472
D
Q
P
S
L
T
C
T
S
E
A
F
S
S
Y
Site 41
S473
Q
P
S
L
T
C
T
S
E
A
F
S
S
Y
F
Site 42
S477
T
C
T
S
E
A
F
S
S
Y
F
N
K
V
G
Site 43
S478
C
T
S
E
A
F
S
S
Y
F
N
K
V
G
V
Site 44
Y479
T
S
E
A
F
S
S
Y
F
N
K
V
G
V
A
Site 45
T489
K
V
G
V
A
Q
D
T
D
D
C
D
D
F
D
Site 46
S498
D
C
D
D
F
D
I
S
Q
L
N
L
T
P
V
Site 47
T503
D
I
S
Q
L
N
L
T
P
V
T
S
T
T
P
Site 48
T506
Q
L
N
L
T
P
V
T
S
T
T
P
S
T
N
Site 49
S507
L
N
L
T
P
V
T
S
T
T
P
S
T
N
S
Site 50
T509
L
T
P
V
T
S
T
T
P
S
T
N
S
P
P
Site 51
S511
P
V
T
S
T
T
P
S
T
N
S
P
P
T
P
Site 52
T512
V
T
S
T
T
P
S
T
N
S
P
P
T
P
A
Site 53
S514
S
T
T
P
S
T
N
S
P
P
T
P
A
P
R
Site 54
T517
P
S
T
N
S
P
P
T
P
A
P
R
Q
S
S
Site 55
S523
P
T
P
A
P
R
Q
S
S
P
S
K
S
S
A
Site 56
S524
T
P
A
P
R
Q
S
S
P
S
K
S
S
A
S
Site 57
S526
A
P
R
Q
S
S
P
S
K
S
S
A
S
H
A
Site 58
S528
R
Q
S
S
P
S
K
S
S
A
S
H
A
S
D
Site 59
S529
Q
S
S
P
S
K
S
S
A
S
H
A
S
D
P
Site 60
S531
S
P
S
K
S
S
A
S
H
A
S
D
P
T
T
Site 61
T538
S
H
A
S
D
P
T
T
D
D
I
F
E
E
G
Site 62
S548
I
F
E
E
G
F
E
S
P
S
K
S
E
E
Q
Site 63
S550
E
E
G
F
E
S
P
S
K
S
E
E
Q
E
A
Site 64
S552
G
F
E
S
P
S
K
S
E
E
Q
E
A
P
D
Site 65
S561
E
Q
E
A
P
D
G
S
Q
A
S
S
N
S
D
Site 66
S564
A
P
D
G
S
Q
A
S
S
N
S
D
P
F
G
Site 67
S565
P
D
G
S
Q
A
S
S
N
S
D
P
F
G
E
Site 68
S567
G
S
Q
A
S
S
N
S
D
P
F
G
E
P
S
Site 69
S574
S
D
P
F
G
E
P
S
G
E
P
S
G
D
N
Site 70
S578
G
E
P
S
G
E
P
S
G
D
N
I
S
P
Q
Site 71
S583
E
P
S
G
D
N
I
S
P
Q
A
G
S
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation