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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PRPF40A
Full Name:
Pre-mRNA-processing factor 40 homolog A
Alias:
Fas-ligand associated factor 1; FLAF1; FNB3; Formin-binding protein 3; HSPC225; Huntingtin- interacting protein HYPA/FBP11; Huntingtin yeast partner A; HYPA; NY- REN-6 antigen; PR40A; PRP40
Type:
RNA processing, pre-RNA splicing
Mass (Da):
108805
Number AA:
957
UniProt ID:
O75400
International Prot ID:
IPI00337385
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0016604
GO:0016607
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0005515
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006396
GO:0006397
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T5
_
_
_
M
R
P
G
T
G
A
E
R
G
G
L
Site 2
S15
E
R
G
G
L
M
V
S
E
M
E
S
H
P
P
Site 3
S19
L
M
V
S
E
M
E
S
H
P
P
S
Q
G
P
Site 4
S23
E
M
E
S
H
P
P
S
Q
G
P
G
D
G
E
Site 5
S34
G
D
G
E
R
R
L
S
G
S
S
L
C
S
G
Site 6
S36
G
E
R
R
L
S
G
S
S
L
C
S
G
S
W
Site 7
S37
E
R
R
L
S
G
S
S
L
C
S
G
S
W
V
Site 8
S45
L
C
S
G
S
W
V
S
A
D
G
F
L
R
R
Site 9
S55
G
F
L
R
R
R
P
S
M
G
H
P
G
M
H
Site 10
S120
M
S
H
M
S
Q
A
S
M
Q
P
A
L
P
P
Site 11
S140
D
V
A
A
G
T
A
S
G
A
K
S
M
W
T
Site 12
S144
G
T
A
S
G
A
K
S
M
W
T
E
H
K
S
Site 13
T147
S
G
A
K
S
M
W
T
E
H
K
S
P
D
G
Site 14
S151
S
M
W
T
E
H
K
S
P
D
G
R
T
Y
Y
Site 15
Y157
K
S
P
D
G
R
T
Y
Y
Y
N
T
E
T
K
Site 16
Y158
S
P
D
G
R
T
Y
Y
Y
N
T
E
T
K
Q
Site 17
Y159
P
D
G
R
T
Y
Y
Y
N
T
E
T
K
Q
S
Site 18
S166
Y
N
T
E
T
K
Q
S
T
W
E
K
P
D
D
Site 19
T176
E
K
P
D
D
L
K
T
P
A
E
Q
L
L
S
Site 20
S183
T
P
A
E
Q
L
L
S
K
C
P
W
K
E
Y
Site 21
Y190
S
K
C
P
W
K
E
Y
K
S
D
S
G
K
P
Site 22
Y198
K
S
D
S
G
K
P
Y
Y
Y
N
S
Q
T
K
Site 23
Y199
S
D
S
G
K
P
Y
Y
Y
N
S
Q
T
K
E
Site 24
Y200
D
S
G
K
P
Y
Y
Y
N
S
Q
T
K
E
S
Site 25
S202
G
K
P
Y
Y
Y
N
S
Q
T
K
E
S
R
W
Site 26
Y221
E
L
E
D
L
E
G
Y
Q
N
T
I
V
A
G
Site 27
T253
S
K
Q
E
E
C
T
T
T
S
T
A
P
V
P
Site 28
T262
S
T
A
P
V
P
T
T
E
I
P
T
T
M
S
Site 29
S299
A
A
A
N
A
N
A
S
T
S
A
S
N
T
V
Site 30
S301
A
N
A
N
A
S
T
S
A
S
N
T
V
S
G
Site 31
S303
A
N
A
S
T
S
A
S
N
T
V
S
G
T
V
Site 32
T331
T
V
V
D
N
E
N
T
V
T
I
S
T
E
E
Site 33
T333
V
D
N
E
N
T
V
T
I
S
T
E
E
Q
A
Site 34
T345
E
Q
A
Q
L
T
S
T
P
A
I
Q
D
Q
S
Site 35
S352
T
P
A
I
Q
D
Q
S
V
E
V
S
S
N
T
Site 36
S356
Q
D
Q
S
V
E
V
S
S
N
T
G
E
E
T
Site 37
T368
E
E
T
S
K
Q
E
T
V
A
D
F
T
P
K
Site 38
T373
Q
E
T
V
A
D
F
T
P
K
K
E
E
E
E
Site 39
S381
P
K
K
E
E
E
E
S
Q
P
A
K
K
T
Y
Site 40
S411
L
K
E
K
R
V
P
S
N
A
S
W
E
Q
A
Site 41
S414
K
R
V
P
S
N
A
S
W
E
Q
A
M
K
M
Site 42
S429
I
I
N
D
P
R
Y
S
A
L
A
K
L
S
E
Site 43
S458
E
E
K
E
E
A
R
S
K
Y
K
E
A
K
E
Site 44
Y460
K
E
E
A
R
S
K
Y
K
E
A
K
E
S
F
Site 45
S466
K
Y
K
E
A
K
E
S
F
Q
R
F
L
E
N
Site 46
T478
L
E
N
H
E
K
M
T
S
T
T
R
Y
K
K
Site 47
S479
E
N
H
E
K
M
T
S
T
T
R
Y
K
K
A
Site 48
Y483
K
M
T
S
T
T
R
Y
K
K
A
E
Q
M
F
Site 49
S500
M
E
V
W
N
A
I
S
E
R
D
R
L
E
I
Site 50
Y508
E
R
D
R
L
E
I
Y
E
D
V
L
F
F
L
Site 51
S516
E
D
V
L
F
F
L
S
K
K
E
K
E
Q
A
Site 52
Y556
T
W
S
E
A
Q
Q
Y
L
M
D
N
P
T
F
Site 53
T562
Q
Y
L
M
D
N
P
T
F
A
E
D
E
E
L
Site 54
S599
E
E
E
E
K
Q
K
S
L
L
R
E
R
R
R
Site 55
S613
R
Q
R
K
N
R
E
S
F
Q
I
F
L
D
E
Site 56
S632
G
Q
L
H
S
M
S
S
W
M
E
L
Y
P
T
Site 57
Y637
M
S
S
W
M
E
L
Y
P
T
I
S
S
D
I
Site 58
T639
S
W
M
E
L
Y
P
T
I
S
S
D
I
R
F
Site 59
S641
M
E
L
Y
P
T
I
S
S
D
I
R
F
T
N
Site 60
S642
E
L
Y
P
T
I
S
S
D
I
R
F
T
N
M
Site 61
T647
I
S
S
D
I
R
F
T
N
M
L
G
Q
P
G
Site 62
S655
N
M
L
G
Q
P
G
S
T
A
L
D
L
F
K
Site 63
S704
E
D
F
V
A
I
I
S
S
T
K
R
S
T
T
Site 64
S709
I
I
S
S
T
K
R
S
T
T
L
D
A
G
N
Site 65
T710
I
S
S
T
K
R
S
T
T
L
D
A
G
N
I
Site 66
T711
S
S
T
K
R
S
T
T
L
D
A
G
N
I
K
Site 67
S748
R
K
M
K
R
K
E
S
A
F
K
S
M
L
K
Site 68
S752
R
K
E
S
A
F
K
S
M
L
K
Q
A
A
P
Site 69
T784
E
P
A
F
E
D
I
T
L
E
S
E
R
K
R
Site 70
S787
F
E
D
I
T
L
E
S
E
R
K
R
I
F
K
Site 71
S809
H
E
C
Q
H
H
H
S
K
N
K
K
H
S
K
Site 72
S815
H
S
K
N
K
K
H
S
K
K
S
K
K
H
H
Site 73
S818
N
K
K
H
S
K
K
S
K
K
H
H
R
K
R
Site 74
S826
K
K
H
H
R
K
R
S
R
S
R
S
G
S
D
Site 75
S828
H
H
R
K
R
S
R
S
R
S
G
S
D
S
D
Site 76
S830
R
K
R
S
R
S
R
S
G
S
D
S
D
D
D
Site 77
S832
R
S
R
S
R
S
G
S
D
S
D
D
D
D
S
Site 78
S834
R
S
R
S
G
S
D
S
D
D
D
D
S
H
S
Site 79
S839
S
D
S
D
D
D
D
S
H
S
K
K
K
R
Q
Site 80
S841
S
D
D
D
D
S
H
S
K
K
K
R
Q
R
S
Site 81
S848
S
K
K
K
R
Q
R
S
E
S
R
S
A
S
E
Site 82
S850
K
K
R
Q
R
S
E
S
R
S
A
S
E
H
S
Site 83
S852
R
Q
R
S
E
S
R
S
A
S
E
H
S
S
S
Site 84
S854
R
S
E
S
R
S
A
S
E
H
S
S
S
A
E
Site 85
S857
S
R
S
A
S
E
H
S
S
S
A
E
S
E
R
Site 86
S858
R
S
A
S
E
H
S
S
S
A
E
S
E
R
S
Site 87
S859
S
A
S
E
H
S
S
S
A
E
S
E
R
S
Y
Site 88
S862
E
H
S
S
S
A
E
S
E
R
S
Y
K
K
S
Site 89
S865
S
S
A
E
S
E
R
S
Y
K
K
S
K
K
H
Site 90
Y866
S
A
E
S
E
R
S
Y
K
K
S
K
K
H
K
Site 91
S869
S
E
R
S
Y
K
K
S
K
K
H
K
K
K
S
Site 92
S876
S
K
K
H
K
K
K
S
K
K
R
R
H
K
S
Site 93
S883
S
K
K
R
R
H
K
S
D
S
P
E
S
D
A
Site 94
S885
K
R
R
H
K
S
D
S
P
E
S
D
A
E
R
Site 95
S888
H
K
S
D
S
P
E
S
D
A
E
R
E
K
D
Site 96
S903
K
K
E
K
D
R
E
S
E
K
D
R
T
R
Q
Site 97
T908
R
E
S
E
K
D
R
T
R
Q
R
S
E
S
K
Site 98
S912
K
D
R
T
R
Q
R
S
E
S
K
H
K
S
P
Site 99
S914
R
T
R
Q
R
S
E
S
K
H
K
S
P
K
K
Site 100
S918
R
S
E
S
K
H
K
S
P
K
K
K
T
G
K
Site 101
T923
H
K
S
P
K
K
K
T
G
K
D
S
G
N
W
Site 102
S927
K
K
K
T
G
K
D
S
G
N
W
D
T
S
G
Site 103
T932
K
D
S
G
N
W
D
T
S
G
S
E
L
S
E
Site 104
S933
D
S
G
N
W
D
T
S
G
S
E
L
S
E
G
Site 105
S935
G
N
W
D
T
S
G
S
E
L
S
E
G
E
L
Site 106
S938
D
T
S
G
S
E
L
S
E
G
E
L
E
K
R
Site 107
T948
E
L
E
K
R
R
R
T
L
L
E
Q
L
D
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation