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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CNOT3
Full Name:
CCR4-NOT transcription complex subunit 3
Alias:
CCR4-associated factor 3; CCR4-NOT transcription complex, subunit 3; CNO3; KIAA0691; LENG2; NOT3 (negative regulator of transcription 3); NOT3H
Type:
Mass (Da):
81872
Number AA:
753
UniProt ID:
O75175
International Prot ID:
IPI00005015
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0030528
PhosphoSite+
KinaseNET
Biological Process:
GO:0045449
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y44
N
A
N
Q
K
E
K
Y
E
A
D
L
K
K
E
Site 2
T64
R
L
R
D
Q
I
K
T
W
V
A
S
N
E
I
Site 3
T86
D
N
R
K
L
I
E
T
Q
M
E
R
F
K
V
Site 4
T98
F
K
V
V
E
R
E
T
K
T
K
A
Y
S
K
Site 5
T100
V
V
E
R
E
T
K
T
K
A
Y
S
K
E
G
Site 6
S104
E
T
K
T
K
A
Y
S
K
E
G
L
G
L
A
Site 7
S144
M
Q
V
D
Q
F
E
S
E
V
E
S
L
S
V
Site 8
S148
Q
F
E
S
E
V
E
S
L
S
V
Q
T
R
K
Site 9
S150
E
S
E
V
E
S
L
S
V
Q
T
R
K
K
K
Site 10
Y178
R
H
I
E
K
H
R
Y
H
V
R
M
L
E
T
Site 11
S194
L
R
M
L
D
N
D
S
I
L
V
D
A
I
R
Site 12
Y209
K
I
K
D
D
V
E
Y
Y
V
D
S
S
Q
D
Site 13
Y210
I
K
D
D
V
E
Y
Y
V
D
S
S
Q
D
P
Site 14
S214
V
E
Y
Y
V
D
S
S
Q
D
P
D
F
E
E
Site 15
Y226
F
E
E
N
E
F
L
Y
D
D
L
D
L
E
D
Site 16
T241
I
P
Q
A
L
V
A
T
S
P
P
S
H
S
H
Site 17
S242
P
Q
A
L
V
A
T
S
P
P
S
H
S
H
M
Site 18
S245
L
V
A
T
S
P
P
S
H
S
H
M
E
D
E
Site 19
S247
A
T
S
P
P
S
H
S
H
M
E
D
E
I
F
Site 20
S257
E
D
E
I
F
N
Q
S
S
S
T
P
T
S
T
Site 21
S259
E
I
F
N
Q
S
S
S
T
P
T
S
T
T
S
Site 22
T260
I
F
N
Q
S
S
S
T
P
T
S
T
T
S
S
Site 23
T262
N
Q
S
S
S
T
P
T
S
T
T
S
S
S
P
Site 24
S263
Q
S
S
S
T
P
T
S
T
T
S
S
S
P
I
Site 25
T264
S
S
S
T
P
T
S
T
T
S
S
S
P
I
P
Site 26
T265
S
S
T
P
T
S
T
T
S
S
S
P
I
P
P
Site 27
S266
S
T
P
T
S
T
T
S
S
S
P
I
P
P
S
Site 28
S267
T
P
T
S
T
T
S
S
S
P
I
P
P
S
P
Site 29
S268
P
T
S
T
T
S
S
S
P
I
P
P
S
P
A
Site 30
S273
S
S
S
P
I
P
P
S
P
A
N
C
T
T
E
Site 31
T278
P
P
S
P
A
N
C
T
T
E
N
S
E
D
D
Site 32
S291
D
D
K
K
R
G
R
S
T
D
S
E
V
S
Q
Site 33
T292
D
K
K
R
G
R
S
T
D
S
E
V
S
Q
S
Site 34
S294
K
R
G
R
S
T
D
S
E
V
S
Q
S
P
A
Site 35
S297
R
S
T
D
S
E
V
S
Q
S
P
A
K
N
G
Site 36
S299
T
D
S
E
V
S
Q
S
P
A
K
N
G
S
K
Site 37
S305
Q
S
P
A
K
N
G
S
K
P
V
H
S
N
Q
Site 38
S310
N
G
S
K
P
V
H
S
N
Q
H
P
Q
S
P
Site 39
S316
H
S
N
Q
H
P
Q
S
P
A
V
P
P
T
Y
Site 40
T322
Q
S
P
A
V
P
P
T
Y
P
S
G
P
P
P
Site 41
Y323
S
P
A
V
P
P
T
Y
P
S
G
P
P
P
A
Site 42
S325
A
V
P
P
T
Y
P
S
G
P
P
P
A
A
S
Site 43
S332
S
G
P
P
P
A
A
S
A
L
S
T
T
P
G
Site 44
S335
P
P
A
A
S
A
L
S
T
T
P
G
N
N
G
Site 45
T336
P
A
A
S
A
L
S
T
T
P
G
N
N
G
V
Site 46
T337
A
A
S
A
L
S
T
T
P
G
N
N
G
V
P
Site 47
S351
P
A
P
A
A
P
P
S
A
L
G
P
K
A
S
Site 48
S358
S
A
L
G
P
K
A
S
P
A
P
S
H
N
S
Site 49
S362
P
K
A
S
P
A
P
S
H
N
S
G
T
P
A
Site 50
S365
S
P
A
P
S
H
N
S
G
T
P
A
P
Y
A
Site 51
T367
A
P
S
H
N
S
G
T
P
A
P
Y
A
Q
A
Site 52
S381
A
V
A
P
P
A
P
S
G
P
S
T
T
Q
P
Site 53
T385
P
A
P
S
G
P
S
T
T
Q
P
R
P
P
S
Site 54
T386
A
P
S
G
P
S
T
T
Q
P
R
P
P
S
V
Site 55
S392
T
T
Q
P
R
P
P
S
V
Q
P
S
G
G
G
Site 56
S396
R
P
P
S
V
Q
P
S
G
G
G
G
G
G
S
Site 57
S403
S
G
G
G
G
G
G
S
G
G
G
G
S
S
S
Site 58
S408
G
G
S
G
G
G
G
S
S
S
S
S
N
S
S
Site 59
S409
G
S
G
G
G
G
S
S
S
S
S
N
S
S
A
Site 60
S410
S
G
G
G
G
S
S
S
S
S
N
S
S
A
G
Site 61
S411
G
G
G
G
S
S
S
S
S
N
S
S
A
G
G
Site 62
S412
G
G
G
S
S
S
S
S
N
S
S
A
G
G
G
Site 63
S414
G
S
S
S
S
S
N
S
S
A
G
G
G
A
G
Site 64
S415
S
S
S
S
S
N
S
S
A
G
G
G
A
G
K
Site 65
S428
G
K
Q
N
G
A
T
S
Y
S
S
V
V
A
D
Site 66
S430
Q
N
G
A
T
S
Y
S
S
V
V
A
D
S
P
Site 67
S431
N
G
A
T
S
Y
S
S
V
V
A
D
S
P
A
Site 68
S436
Y
S
S
V
V
A
D
S
P
A
E
V
A
L
S
Site 69
S443
S
P
A
E
V
A
L
S
S
S
G
G
N
N
A
Site 70
S451
S
S
G
G
N
N
A
S
S
Q
A
L
G
P
P
Site 71
S452
S
G
G
N
N
A
S
S
Q
A
L
G
P
P
S
Site 72
S459
S
Q
A
L
G
P
P
S
G
P
H
N
P
P
P
Site 73
S467
G
P
H
N
P
P
P
S
T
S
K
E
P
S
A
Site 74
S469
H
N
P
P
P
S
T
S
K
E
P
S
A
A
A
Site 75
S473
P
S
T
S
K
E
P
S
A
A
A
P
T
G
A
Site 76
S487
A
G
G
V
A
P
G
S
G
N
N
S
G
G
P
Site 77
S491
A
P
G
S
G
N
N
S
G
G
P
S
L
L
V
Site 78
S506
P
L
P
V
N
P
P
S
S
P
T
P
S
F
S
Site 79
S507
L
P
V
N
P
P
S
S
P
T
P
S
F
S
D
Site 80
T509
V
N
P
P
S
S
P
T
P
S
F
S
D
A
K
Site 81
S511
P
P
S
S
P
T
P
S
F
S
D
A
K
A
A
Site 82
S513
S
S
P
T
P
S
F
S
D
A
K
A
A
G
A
Site 83
S529
L
N
G
P
P
Q
F
S
T
A
P
E
I
K
A
Site 84
S541
I
K
A
P
E
P
L
S
S
L
K
S
M
A
E
Site 85
S542
K
A
P
E
P
L
S
S
L
K
S
M
A
E
R
Site 86
S545
E
P
L
S
S
L
K
S
M
A
E
R
A
A
I
Site 87
S554
A
E
R
A
A
I
S
S
G
I
E
D
P
V
P
Site 88
S573
T
E
R
D
I
I
L
S
S
T
S
A
P
P
A
Site 89
S574
E
R
D
I
I
L
S
S
T
S
A
P
P
A
S
Site 90
T575
R
D
I
I
L
S
S
T
S
A
P
P
A
S
A
Site 91
S581
S
T
S
A
P
P
A
S
A
Q
P
P
L
Q
L
Site 92
S589
A
Q
P
P
L
Q
L
S
E
V
N
I
P
L
S
Site 93
T608
P
L
G
P
V
P
L
T
K
E
Q
L
Y
Q
Q
Site 94
Y613
P
L
T
K
E
Q
L
Y
Q
Q
A
M
E
E
A
Site 95
S631
H
M
P
H
P
S
D
S
E
R
I
R
Q
Y
L
Site 96
Y637
D
S
E
R
I
R
Q
Y
L
P
R
N
P
C
P
Site 97
T645
L
P
R
N
P
C
P
T
P
P
Y
H
H
Q
M
Site 98
T659
M
P
P
P
H
S
D
T
V
E
F
Y
Q
R
L
Site 99
Y663
H
S
D
T
V
E
F
Y
Q
R
L
S
T
E
T
Site 100
Y685
L
E
G
T
K
A
Q
Y
L
A
A
K
A
L
K
Site 101
T714
Q
R
H
E
E
P
K
T
I
T
D
E
F
E
Q
Site 102
Y724
D
E
F
E
Q
G
T
Y
I
Y
F
D
Y
E
K
Site 103
Y726
F
E
Q
G
T
Y
I
Y
F
D
Y
E
K
W
G
Site 104
Y729
G
T
Y
I
Y
F
D
Y
E
K
W
G
Q
R
K
Site 105
T741
Q
R
K
K
E
G
F
T
F
E
Y
R
Y
L
E
Site 106
Y744
K
E
G
F
T
F
E
Y
R
Y
L
E
D
R
D
Site 107
Y746
G
F
T
F
E
Y
R
Y
L
E
D
R
D
L
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation