KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
BRD4
Full Name:
Bromodomain-containing protein 4
Alias:
Bromodomain containing 4; CAP; Chromosome-associated protein; HUNK1; HUNKI; MCAP
Type:
Protein kinase, Ser/Thr (non-receptor); ATYPICAL group; BRD family
Mass (Da):
152219
Number AA:
1362
UniProt ID:
O60885
International Prot ID:
IPI00440727
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
S
A
E
S
G
P
G
T
R
L
R
N
L
P
V
Site 2
S24
M
G
D
G
L
E
T
S
Q
M
S
T
T
Q
A
Site 3
S42
P
Q
P
A
N
A
A
S
T
N
P
P
P
P
E
Site 4
T43
Q
P
A
N
A
A
S
T
N
P
P
P
P
E
T
Site 5
T50
T
N
P
P
P
P
E
T
S
N
P
N
K
P
K
Site 6
S51
N
P
P
P
P
E
T
S
N
P
N
K
P
K
R
Site 7
T60
P
N
K
P
K
R
Q
T
N
Q
L
Q
Y
L
L
Site 8
Y65
R
Q
T
N
Q
L
Q
Y
L
L
R
V
V
L
K
Site 9
Y97
V
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
Site 10
Y98
K
L
N
L
P
D
Y
Y
K
I
I
K
T
P
M
Site 11
T103
D
Y
Y
K
I
I
K
T
P
M
D
M
G
T
I
Site 12
T109
K
T
P
M
D
M
G
T
I
K
K
R
L
E
N
Site 13
Y118
K
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
Site 14
Y119
K
R
L
E
N
N
Y
Y
W
N
A
Q
E
C
I
Site 15
Y139
M
F
T
N
C
Y
I
Y
N
K
P
G
D
D
I
Site 16
T186
R
G
R
G
R
K
E
T
G
T
A
K
P
G
V
Site 17
T188
R
G
R
K
E
T
G
T
A
K
P
G
V
S
T
Site 18
T195
T
A
K
P
G
V
S
T
V
P
N
T
T
Q
A
Site 19
T199
G
V
S
T
V
P
N
T
T
Q
A
S
T
P
P
Site 20
T204
P
N
T
T
Q
A
S
T
P
P
Q
T
Q
T
P
Site 21
T208
Q
A
S
T
P
P
Q
T
Q
T
P
Q
P
N
P
Site 22
T210
S
T
P
P
Q
T
Q
T
P
Q
P
N
P
P
P
Site 23
T221
N
P
P
P
V
Q
A
T
P
H
P
F
P
A
V
Site 24
T249
V
P
P
Q
P
L
Q
T
P
P
P
V
P
P
Q
Site 25
S270
P
A
P
Q
P
V
Q
S
H
P
P
I
I
A
A
Site 26
T278
H
P
P
I
I
A
A
T
P
Q
P
V
K
T
K
Site 27
T294
G
V
K
R
K
A
D
T
T
T
P
T
T
I
D
Site 28
T295
V
K
R
K
A
D
T
T
T
P
T
T
I
D
P
Site 29
T296
K
R
K
A
D
T
T
T
P
T
T
I
D
P
I
Site 30
T299
A
D
T
T
T
P
T
T
I
D
P
I
H
E
P
Site 31
S308
D
P
I
H
E
P
P
S
L
P
P
E
P
K
T
Site 32
T315
S
L
P
P
E
P
K
T
T
K
L
G
Q
R
R
Site 33
T316
L
P
P
E
P
K
T
T
K
L
G
Q
R
R
E
Site 34
S324
K
L
G
Q
R
R
E
S
S
R
P
V
K
P
P
Site 35
S325
L
G
Q
R
R
E
S
S
R
P
V
K
P
P
K
Site 36
S338
P
K
K
D
V
P
D
S
Q
Q
H
P
A
P
E
Site 37
S347
Q
H
P
A
P
E
K
S
S
K
V
S
E
Q
L
Site 38
S351
P
E
K
S
S
K
V
S
E
Q
L
K
C
C
S
Site 39
Y372
F
A
K
K
H
A
A
Y
A
W
P
F
Y
K
P
Site 40
Y390
E
A
L
G
L
H
D
Y
C
D
I
I
K
H
P
Site 41
S401
I
K
H
P
M
D
M
S
T
I
K
S
K
L
E
Site 42
T402
K
H
P
M
D
M
S
T
I
K
S
K
L
E
A
Site 43
S405
M
D
M
S
T
I
K
S
K
L
E
A
R
E
Y
Site 44
Y412
S
K
L
E
A
R
E
Y
R
D
A
Q
E
F
G
Site 45
Y430
R
L
M
F
S
N
C
Y
K
Y
N
P
P
D
H
Site 46
Y432
M
F
S
N
C
Y
K
Y
N
P
P
D
H
E
V
Site 47
S469
E
E
P
V
V
A
V
S
S
P
A
V
P
P
P
Site 48
S470
E
P
V
V
A
V
S
S
P
A
V
P
P
P
T
Site 49
T477
S
P
A
V
P
P
P
T
K
V
V
A
P
P
S
Site 50
S484
T
K
V
V
A
P
P
S
S
S
D
S
S
S
D
Site 51
S485
K
V
V
A
P
P
S
S
S
D
S
S
S
D
S
Site 52
S486
V
V
A
P
P
S
S
S
D
S
S
S
D
S
S
Site 53
S488
A
P
P
S
S
S
D
S
S
S
D
S
S
S
D
Site 54
S489
P
P
S
S
S
D
S
S
S
D
S
S
S
D
S
Site 55
S490
P
S
S
S
D
S
S
S
D
S
S
S
D
S
D
Site 56
S492
S
S
D
S
S
S
D
S
S
S
D
S
D
S
S
Site 57
S493
S
D
S
S
S
D
S
S
S
D
S
D
S
S
T
Site 58
S494
D
S
S
S
D
S
S
S
D
S
D
S
S
T
D
Site 59
S496
S
S
D
S
S
S
D
S
D
S
S
T
D
D
S
Site 60
S498
D
S
S
S
D
S
D
S
S
T
D
D
S
E
E
Site 61
S499
S
S
S
D
S
D
S
S
T
D
D
S
E
E
E
Site 62
T500
S
S
D
S
D
S
S
T
D
D
S
E
E
E
R
Site 63
S503
S
D
S
S
T
D
D
S
E
E
E
R
A
Q
R
Site 64
S529
H
E
Q
L
A
A
L
S
Q
P
Q
Q
N
K
P
Site 65
S563
E
V
E
E
N
K
K
S
K
A
K
E
P
P
P
Site 66
T573
K
E
P
P
P
K
K
T
K
K
N
N
S
S
N
Site 67
S578
K
K
T
K
K
N
N
S
S
N
S
N
V
S
K
Site 68
S579
K
T
K
K
N
N
S
S
N
S
N
V
S
K
K
Site 69
S581
K
K
N
N
S
S
N
S
N
V
S
K
K
E
P
Site 70
S584
N
S
S
N
S
N
V
S
K
K
E
P
A
P
M
Site 71
S593
K
E
P
A
P
M
K
S
K
P
P
P
T
Y
E
Site 72
T598
M
K
S
K
P
P
P
T
Y
E
S
E
E
E
D
Site 73
Y599
K
S
K
P
P
P
T
Y
E
S
E
E
E
D
K
Site 74
S601
K
P
P
P
T
Y
E
S
E
E
E
D
K
C
K
Site 75
S611
E
D
K
C
K
P
M
S
Y
E
E
K
R
Q
L
Site 76
S619
Y
E
E
K
R
Q
L
S
L
D
I
N
K
L
P
Site 77
S639
R
V
V
H
I
I
Q
S
R
E
P
S
L
K
N
Site 78
S643
I
I
Q
S
R
E
P
S
L
K
N
S
N
P
D
Site 79
S647
R
E
P
S
L
K
N
S
N
P
D
E
I
E
I
Site 80
T658
E
I
E
I
D
F
E
T
L
K
P
S
T
L
R
Site 81
S662
D
F
E
T
L
K
P
S
T
L
R
E
L
E
R
Site 82
T663
F
E
T
L
K
P
S
T
L
R
E
L
E
R
Y
Site 83
Y670
T
L
R
E
L
E
R
Y
V
T
S
C
L
R
K
Site 84
T672
R
E
L
E
R
Y
V
T
S
C
L
R
K
K
R
Site 85
S673
E
L
E
R
Y
V
T
S
C
L
R
K
K
R
K
Site 86
S692
K
V
D
V
I
A
G
S
S
K
M
K
G
F
S
Site 87
S699
S
S
K
M
K
G
F
S
S
S
E
S
E
S
S
Site 88
S700
S
K
M
K
G
F
S
S
S
E
S
E
S
S
S
Site 89
S701
K
M
K
G
F
S
S
S
E
S
E
S
S
S
E
Site 90
S703
K
G
F
S
S
S
E
S
E
S
S
S
E
S
S
Site 91
S705
F
S
S
S
E
S
E
S
S
S
E
S
S
S
S
Site 92
S706
S
S
S
E
S
E
S
S
S
E
S
S
S
S
D
Site 93
S707
S
S
E
S
E
S
S
S
E
S
S
S
S
D
S
Site 94
S709
E
S
E
S
S
S
E
S
S
S
S
D
S
E
D
Site 95
S710
S
E
S
S
S
E
S
S
S
S
D
S
E
D
S
Site 96
S711
E
S
S
S
E
S
S
S
S
D
S
E
D
S
E
Site 97
S712
S
S
S
E
S
S
S
S
D
S
E
D
S
E
T
Site 98
S714
S
E
S
S
S
S
D
S
E
D
S
E
T
E
M
Site 99
S717
S
S
S
D
S
E
D
S
E
T
E
M
A
P
K
Site 100
T719
S
D
S
E
D
S
E
T
E
M
A
P
K
S
K
Site 101
S725
E
T
E
M
A
P
K
S
K
K
K
G
H
P
G
Site 102
S784
P
P
P
P
P
P
P
S
M
P
Q
Q
A
A
P
Site 103
S795
Q
A
A
P
A
M
K
S
S
P
P
P
F
I
A
Site 104
S796
A
A
P
A
M
K
S
S
P
P
P
F
I
A
T
Site 105
T803
S
P
P
P
F
I
A
T
Q
V
P
V
L
E
P
Site 106
S815
L
E
P
Q
L
P
G
S
V
F
D
P
I
G
H
Site 107
S846
L
P
Q
P
P
E
H
S
T
P
P
H
L
N
Q
Site 108
T847
P
Q
P
P
E
H
S
T
P
P
H
L
N
Q
H
Site 109
S858
L
N
Q
H
A
V
V
S
P
P
A
L
H
N
A
Site 110
S871
N
A
L
P
Q
Q
P
S
R
P
S
N
R
A
A
Site 111
S874
P
Q
Q
P
S
R
P
S
N
R
A
A
A
L
P
Site 112
S891
P
A
R
P
P
A
V
S
P
A
L
T
Q
T
P
Site 113
T897
V
S
P
A
L
T
Q
T
P
L
L
P
Q
P
P
Site 114
T924
E
P
P
A
P
P
L
T
S
M
Q
M
Q
L
Y
Site 115
S925
P
P
A
P
P
L
T
S
M
Q
M
Q
L
Y
L
Site 116
Y931
T
S
M
Q
M
Q
L
Y
L
Q
Q
L
Q
K
V
Site 117
T942
L
Q
K
V
Q
P
P
T
P
L
L
P
S
V
K
Site 118
S947
P
P
T
P
L
L
P
S
V
K
V
Q
S
Q
P
Site 119
S952
L
P
S
V
K
V
Q
S
Q
P
P
P
P
L
P
Site 120
S965
L
P
P
P
P
H
P
S
V
Q
Q
Q
L
Q
Q
Site 121
S1045
Q
V
I
Q
H
H
H
S
P
R
H
H
K
S
D
Site 122
S1051
H
S
P
R
H
H
K
S
D
P
Y
S
T
G
H
Site 123
Y1054
R
H
H
K
S
D
P
Y
S
T
G
H
L
R
E
Site 124
S1055
H
H
K
S
D
P
Y
S
T
G
H
L
R
E
A
Site 125
S1064
G
H
L
R
E
A
P
S
P
L
M
I
H
S
P
Site 126
S1070
P
S
P
L
M
I
H
S
P
Q
M
S
Q
F
Q
Site 127
S1074
M
I
H
S
P
Q
M
S
Q
F
Q
S
L
T
H
Site 128
S1078
P
Q
M
S
Q
F
Q
S
L
T
H
Q
S
P
P
Site 129
T1080
M
S
Q
F
Q
S
L
T
H
Q
S
P
P
Q
Q
Site 130
S1083
F
Q
S
L
T
H
Q
S
P
P
Q
Q
N
V
Q
Site 131
S1100
K
Q
E
L
R
A
A
S
V
V
Q
P
Q
P
L
Site 132
S1117
V
K
E
E
K
I
H
S
P
I
I
R
S
E
P
Site 133
S1122
I
H
S
P
I
I
R
S
E
P
F
S
P
S
L
Site 134
S1126
I
I
R
S
E
P
F
S
P
S
L
R
P
E
P
Site 135
S1128
R
S
E
P
F
S
P
S
L
R
P
E
P
P
K
Site 136
S1139
E
P
P
K
H
P
E
S
I
K
A
P
V
H
L
Site 137
T1186
K
Q
K
Q
E
P
K
T
P
V
A
P
K
K
D
Site 138
S1201
L
K
I
K
N
M
G
S
W
A
S
L
V
Q
K
Site 139
S1204
K
N
M
G
S
W
A
S
L
V
Q
K
H
P
T
Site 140
T1211
S
L
V
Q
K
H
P
T
T
P
S
S
T
A
K
Site 141
T1212
L
V
Q
K
H
P
T
T
P
S
S
T
A
K
S
Site 142
S1214
Q
K
H
P
T
T
P
S
S
T
A
K
S
S
S
Site 143
S1215
K
H
P
T
T
P
S
S
T
A
K
S
S
S
D
Site 144
T1216
H
P
T
T
P
S
S
T
A
K
S
S
S
D
S
Site 145
S1219
T
P
S
S
T
A
K
S
S
S
D
S
F
E
Q
Site 146
S1220
P
S
S
T
A
K
S
S
S
D
S
F
E
Q
F
Site 147
S1221
S
S
T
A
K
S
S
S
D
S
F
E
Q
F
R
Site 148
S1223
T
A
K
S
S
S
D
S
F
E
Q
F
R
R
A
Site 149
S1262
L
R
Q
E
R
M
R
S
R
E
D
E
D
A
L
Site 150
S1314
A
A
T
P
Q
A
Q
S
S
Q
P
Q
S
M
L
Site 151
S1315
A
T
P
Q
A
Q
S
S
Q
P
Q
S
M
L
D
Site 152
S1319
A
Q
S
S
Q
P
Q
S
M
L
D
Q
Q
R
E
Site 153
S1355
N
F
Q
S
D
L
L
S
I
F
E
E
N
L
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation