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Updated November 2019
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Protein Info
Short Name:
REV3
Full Name:
DNA polymerase zeta catalytic subunit
Alias:
DPOLZ; DPOZ; Polymerase, DNA, zeta; POLZ; REV3L; REV3-like, catalytic subunit of DNA polymerase zeta; Seizure-related protein 4; SEZ4
Type:
EC 2.7.7.7; Transferase; DNA replication
Mass (Da):
352776
Number AA:
3130
UniProt ID:
O60673
International Prot ID:
IPI00248651
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0003887
GO:0000166
PhosphoSite+
KinaseNET
Biological Process:
GO:0006281
GO:0006261
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y12
R
I
V
T
A
D
Y
Y
M
A
S
P
L
Q
G
Site 2
S15
T
A
D
Y
Y
M
A
S
P
L
Q
G
L
D
T
Site 3
T22
S
P
L
Q
G
L
D
T
C
Q
S
P
L
T
Q
Site 4
S25
Q
G
L
D
T
C
Q
S
P
L
T
Q
A
P
V
Site 5
T28
D
T
C
Q
S
P
L
T
Q
A
P
V
K
K
V
Site 6
Y62
H
G
I
F
P
Y
L
Y
V
P
Y
D
G
Y
G
Site 7
Y68
L
Y
V
P
Y
D
G
Y
G
Q
Q
P
E
S
Y
Site 8
S74
G
Y
G
Q
Q
P
E
S
Y
L
S
Q
M
A
F
Site 9
Y75
Y
G
Q
Q
P
E
S
Y
L
S
Q
M
A
F
S
Site 10
S77
Q
Q
P
E
S
Y
L
S
Q
M
A
F
S
I
D
Site 11
S96
V
A
L
G
N
P
S
S
T
A
Q
H
V
F
K
Site 12
Y113
L
V
S
G
M
P
F
Y
G
Y
H
E
K
E
R
Site 13
Y115
S
G
M
P
F
Y
G
Y
H
E
K
E
R
H
F
Site 14
Y126
E
R
H
F
M
K
I
Y
L
Y
N
P
T
M
V
Site 15
Y128
H
F
M
K
I
Y
L
Y
N
P
T
M
V
K
R
Site 16
Y150
G
A
I
M
N
K
F
Y
Q
P
H
E
A
H
I
Site 17
S189
F
R
K
A
R
R
K
S
N
T
L
H
A
T
G
Site 18
T191
K
A
R
R
K
S
N
T
L
H
A
T
G
S
C
Site 19
T195
K
S
N
T
L
H
A
T
G
S
C
K
N
H
L
Site 20
S197
N
T
L
H
A
T
G
S
C
K
N
H
L
S
G
Site 21
S203
G
S
C
K
N
H
L
S
G
N
S
L
A
D
T
Site 22
S206
K
N
H
L
S
G
N
S
L
A
D
T
L
F
R
Site 23
T210
S
G
N
S
L
A
D
T
L
F
R
W
E
Q
D
Site 24
S222
E
Q
D
E
I
P
S
S
L
I
L
E
G
V
E
Site 25
S232
L
E
G
V
E
P
Q
S
T
C
E
L
E
V
D
Site 26
T233
E
G
V
E
P
Q
S
T
C
E
L
E
V
D
A
Site 27
T278
R
R
R
N
R
N
E
T
S
Q
M
S
Q
P
E
Site 28
S279
R
R
N
R
N
E
T
S
Q
M
S
Q
P
E
S
Site 29
S282
R
N
E
T
S
Q
M
S
Q
P
E
S
Q
D
H
Site 30
S286
S
Q
M
S
Q
P
E
S
Q
D
H
R
F
V
P
Site 31
T295
D
H
R
F
V
P
A
T
E
S
E
K
K
F
Q
Site 32
S297
R
F
V
P
A
T
E
S
E
K
K
F
Q
K
R
Site 33
T317
K
Q
N
D
F
S
V
T
L
S
G
S
V
D
Y
Site 34
S319
N
D
F
S
V
T
L
S
G
S
V
D
Y
S
D
Site 35
S321
F
S
V
T
L
S
G
S
V
D
Y
S
D
G
S
Site 36
Y324
T
L
S
G
S
V
D
Y
S
D
G
S
Q
E
F
Site 37
S325
L
S
G
S
V
D
Y
S
D
G
S
Q
E
F
S
Site 38
S328
S
V
D
Y
S
D
G
S
Q
E
F
S
A
E
L
Site 39
S332
S
D
G
S
Q
E
F
S
A
E
L
T
L
H
S
Site 40
T336
Q
E
F
S
A
E
L
T
L
H
S
E
V
L
S
Site 41
S339
S
A
E
L
T
L
H
S
E
V
L
S
P
E
M
Site 42
S343
T
L
H
S
E
V
L
S
P
E
M
L
Q
C
T
Site 43
S389
I
L
N
L
M
E
N
S
Q
T
F
Q
P
L
T
Site 44
T391
N
L
M
E
N
S
Q
T
F
Q
P
L
T
Q
R
Site 45
T396
S
Q
T
F
Q
P
L
T
Q
R
L
S
E
S
P
Site 46
S400
Q
P
L
T
Q
R
L
S
E
S
P
V
F
M
D
Site 47
S402
L
T
Q
R
L
S
E
S
P
V
F
M
D
S
S
Site 48
S408
E
S
P
V
F
M
D
S
S
P
D
E
A
L
V
Site 49
S409
S
P
V
F
M
D
S
S
P
D
E
A
L
V
H
Site 50
Y426
A
G
L
E
S
D
G
Y
R
G
E
R
N
R
M
Site 51
S435
G
E
R
N
R
M
P
S
P
C
R
S
F
G
N
Site 52
S439
R
M
P
S
P
C
R
S
F
G
N
N
K
Y
P
Site 53
Y445
R
S
F
G
N
N
K
Y
P
Q
N
S
D
D
E
Site 54
S466
E
K
E
E
M
E
L
S
L
V
M
S
Q
R
W
Site 55
S470
M
E
L
S
L
V
M
S
Q
R
W
D
S
N
I
Site 56
T491
K
R
S
L
C
R
N
T
H
R
S
S
T
E
D
Site 57
S494
L
C
R
N
T
H
R
S
S
T
E
D
D
D
S
Site 58
S495
C
R
N
T
H
R
S
S
T
E
D
D
D
S
S
Site 59
T496
R
N
T
H
R
S
S
T
E
D
D
D
S
S
S
Site 60
S501
S
S
T
E
D
D
D
S
S
S
G
E
E
M
E
Site 61
S502
S
T
E
D
D
D
S
S
S
G
E
E
M
E
W
Site 62
S503
T
E
D
D
D
S
S
S
G
E
E
M
E
W
S
Site 63
S510
S
G
E
E
M
E
W
S
D
N
S
L
L
L
A
Site 64
S513
E
M
E
W
S
D
N
S
L
L
L
A
S
L
S
Site 65
T527
S
I
P
Q
L
D
G
T
A
D
E
N
S
D
N
Site 66
S532
D
G
T
A
D
E
N
S
D
N
P
L
N
N
E
Site 67
S541
N
P
L
N
N
E
N
S
R
T
H
S
S
V
I
Site 68
T543
L
N
N
E
N
S
R
T
H
S
S
V
I
A
T
Site 69
S545
N
E
N
S
R
T
H
S
S
V
I
A
T
S
K
Site 70
S546
E
N
S
R
T
H
S
S
V
I
A
T
S
K
L
Site 71
T550
T
H
S
S
V
I
A
T
S
K
L
S
V
K
P
Site 72
S558
S
K
L
S
V
K
P
S
I
F
H
K
D
A
A
Site 73
T566
I
F
H
K
D
A
A
T
L
E
P
S
S
S
A
Site 74
S571
A
A
T
L
E
P
S
S
S
A
K
I
T
F
Q
Site 75
S572
A
T
L
E
P
S
S
S
A
K
I
T
F
Q
C
Site 76
T576
P
S
S
S
A
K
I
T
F
Q
C
K
H
T
S
Site 77
T582
I
T
F
Q
C
K
H
T
S
A
L
S
S
H
V
Site 78
S583
T
F
Q
C
K
H
T
S
A
L
S
S
H
V
L
Site 79
S587
K
H
T
S
A
L
S
S
H
V
L
N
K
E
D
Site 80
S600
E
D
L
I
E
D
L
S
Q
T
N
K
N
T
E
Site 81
S613
T
E
K
G
L
D
N
S
V
T
S
F
T
N
E
Site 82
T615
K
G
L
D
N
S
V
T
S
F
T
N
E
S
T
Site 83
S616
G
L
D
N
S
V
T
S
F
T
N
E
S
T
Y
Site 84
S621
V
T
S
F
T
N
E
S
T
Y
S
M
K
Y
P
Site 85
Y623
S
F
T
N
E
S
T
Y
S
M
K
Y
P
G
S
Site 86
S624
F
T
N
E
S
T
Y
S
M
K
Y
P
G
S
L
Site 87
Y627
E
S
T
Y
S
M
K
Y
P
G
S
L
S
S
T
Site 88
S630
Y
S
M
K
Y
P
G
S
L
S
S
T
V
H
S
Site 89
S632
M
K
Y
P
G
S
L
S
S
T
V
H
S
E
N
Site 90
S633
K
Y
P
G
S
L
S
S
T
V
H
S
E
N
S
Site 91
T634
Y
P
G
S
L
S
S
T
V
H
S
E
N
S
H
Site 92
S637
S
L
S
S
T
V
H
S
E
N
S
H
K
E
N
Site 93
S645
E
N
S
H
K
E
N
S
K
K
E
I
L
P
V
Site 94
S653
K
K
E
I
L
P
V
S
S
C
E
S
S
I
F
Site 95
S654
K
E
I
L
P
V
S
S
C
E
S
S
I
F
D
Site 96
S657
L
P
V
S
S
C
E
S
S
I
F
D
Y
E
E
Site 97
S658
P
V
S
S
C
E
S
S
I
F
D
Y
E
E
D
Site 98
Y662
C
E
S
S
I
F
D
Y
E
E
D
I
P
S
V
Site 99
S668
D
Y
E
E
D
I
P
S
V
T
R
Q
V
P
S
Site 100
Y678
R
Q
V
P
S
R
K
Y
T
N
I
R
K
I
E
Site 101
T679
Q
V
P
S
R
K
Y
T
N
I
R
K
I
E
K
Site 102
S706
E
N
T
L
G
K
N
S
F
N
F
S
D
L
N
Site 103
S710
G
K
N
S
F
N
F
S
D
L
N
H
S
K
N
Site 104
S715
N
F
S
D
L
N
H
S
K
N
K
V
S
S
E
Site 105
S729
E
G
N
E
K
G
N
S
T
A
L
S
S
L
F
Site 106
T730
G
N
E
K
G
N
S
T
A
L
S
S
L
F
P
Site 107
S733
K
G
N
S
T
A
L
S
S
L
F
P
S
S
F
Site 108
S734
G
N
S
T
A
L
S
S
L
F
P
S
S
F
T
Site 109
S738
A
L
S
S
L
F
P
S
S
F
T
E
N
C
E
Site 110
S739
L
S
S
L
F
P
S
S
F
T
E
N
C
E
L
Site 111
S748
T
E
N
C
E
L
L
S
C
S
G
E
N
R
T
Site 112
S750
N
C
E
L
L
S
C
S
G
E
N
R
T
M
V
Site 113
T755
S
C
S
G
E
N
R
T
M
V
H
S
L
N
S
Site 114
S759
E
N
R
T
M
V
H
S
L
N
S
T
A
D
E
Site 115
S762
T
M
V
H
S
L
N
S
T
A
D
E
S
G
L
Site 116
T763
M
V
H
S
L
N
S
T
A
D
E
S
G
L
N
Site 117
S767
L
N
S
T
A
D
E
S
G
L
N
K
L
K
I
Site 118
Y776
L
N
K
L
K
I
R
Y
E
E
F
Q
E
H
K
Site 119
T784
E
E
F
Q
E
H
K
T
E
K
P
S
L
S
Q
Site 120
S790
K
T
E
K
P
S
L
S
Q
Q
A
A
H
Y
M
Site 121
T809
V
V
L
S
N
C
L
T
R
P
Q
K
L
S
P
Site 122
S815
L
T
R
P
Q
K
L
S
P
V
T
Y
K
L
Q
Site 123
Y819
Q
K
L
S
P
V
T
Y
K
L
Q
P
G
N
K
Site 124
T845
A
G
H
Q
E
T
S
T
K
S
S
E
T
G
S
Site 125
S847
H
Q
E
T
S
T
K
S
S
E
T
G
S
T
K
Site 126
S848
Q
E
T
S
T
K
S
S
E
T
G
S
T
K
D
Site 127
S852
T
K
S
S
E
T
G
S
T
K
D
N
F
I
Q
Site 128
T853
K
S
S
E
T
G
S
T
K
D
N
F
I
Q
N
Site 129
S875
E
K
D
N
A
L
A
S
D
L
T
K
T
T
R
Site 130
T878
N
A
L
A
S
D
L
T
K
T
T
R
G
A
F
Site 131
T880
L
A
S
D
L
T
K
T
T
R
G
A
F
E
N
Site 132
T889
R
G
A
F
E
N
K
T
P
T
D
G
F
I
D
Site 133
T903
D
C
H
F
G
D
G
T
L
E
T
E
Q
S
F
Site 134
T906
F
G
D
G
T
L
E
T
E
Q
S
F
G
L
Y
Site 135
S909
G
T
L
E
T
E
Q
S
F
G
L
Y
G
N
K
Site 136
Y913
T
E
Q
S
F
G
L
Y
G
N
K
Y
T
L
R
Site 137
Y917
F
G
L
Y
G
N
K
Y
T
L
R
A
K
R
K
Site 138
T918
G
L
Y
G
N
K
Y
T
L
R
A
K
R
K
V
Site 139
T929
K
R
K
V
N
Y
E
T
E
D
S
E
S
S
F
Site 140
S932
V
N
Y
E
T
E
D
S
E
S
S
F
V
T
H
Site 141
S934
Y
E
T
E
D
S
E
S
S
F
V
T
H
N
S
Site 142
S935
E
T
E
D
S
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T1893
S
R
E
E
I
M
A
T
L
L
D
H
D
L
S
Site 295
S1900
T
L
L
D
H
D
L
S
E
T
I
Y
Q
E
P
Site 296
Y1904
H
D
L
S
E
T
I
Y
Q
E
P
F
C
S
N
Site 297
S1910
I
Y
Q
E
P
F
C
S
N
P
S
D
V
P
E
Site 298
S1913
E
P
F
C
S
N
P
S
D
V
P
E
K
P
R
Site 299
S1945
A
E
F
E
G
D
F
S
L
E
G
L
R
L
W
Site 300
T1954
E
G
L
R
L
W
K
T
A
F
S
A
M
T
Q
Site 301
T1960
K
T
A
F
S
A
M
T
Q
N
P
R
P
G
S
Site 302
S1967
T
Q
N
P
R
P
G
S
P
L
R
S
G
Q
G
Site 303
S1971
R
P
G
S
P
L
R
S
G
Q
G
V
V
N
K
Site 304
S1983
V
N
K
G
S
S
N
S
P
K
M
V
E
D
K
Site 305
T2025
R
S
K
K
L
P
K
T
K
P
T
G
V
V
K
Site 306
S2033
K
P
T
G
V
V
K
S
A
E
N
F
S
S
S
Site 307
S2040
S
A
E
N
F
S
S
S
V
N
P
D
D
K
P
Site 308
T2062
V
S
P
C
I
L
P
T
T
A
H
T
K
E
D
Site 309
T2063
S
P
C
I
L
P
T
T
A
H
T
K
E
D
V
Site 310
S2073
T
K
E
D
V
D
N
S
Q
I
A
L
Q
A
P
Site 311
S2085
Q
A
P
T
T
G
C
S
Q
T
A
S
E
S
Q
Site 312
T2087
P
T
T
G
C
S
Q
T
A
S
E
S
Q
M
L
Site 313
S2089
T
G
C
S
Q
T
A
S
E
S
Q
M
L
P
P
Site 314
S2091
C
S
Q
T
A
S
E
S
Q
M
L
P
P
V
A
Site 315
S2099
Q
M
L
P
P
V
A
S
A
S
D
P
E
K
D
Site 316
S2101
L
P
P
V
A
S
A
S
D
P
E
K
D
E
D
Site 317
Y2113
D
E
D
D
D
D
N
Y
Y
I
S
Y
S
S
P
Site 318
Y2114
E
D
D
D
D
N
Y
Y
I
S
Y
S
S
P
D
Site 319
S2116
D
D
D
N
Y
Y
I
S
Y
S
S
P
D
S
P
Site 320
Y2117
D
D
N
Y
Y
I
S
Y
S
S
P
D
S
P
V
Site 321
S2118
D
N
Y
Y
I
S
Y
S
S
P
D
S
P
V
I
Site 322
S2119
N
Y
Y
I
S
Y
S
S
P
D
S
P
V
I
P
Site 323
S2122
I
S
Y
S
S
P
D
S
P
V
I
P
P
W
Q
Site 324
S2133
P
P
W
Q
Q
P
I
S
P
D
S
K
A
L
N
Site 325
S2136
Q
Q
P
I
S
P
D
S
K
A
L
N
G
D
D
Site 326
S2146
L
N
G
D
D
R
P
S
S
P
V
E
E
L
P
Site 327
S2147
N
G
D
D
R
P
S
S
P
V
E
E
L
P
S
Site 328
S2171
I
K
D
G
I
Q
K
S
P
C
S
E
P
Q
E
Site 329
S2174
G
I
Q
K
S
P
C
S
E
P
Q
E
P
L
V
Site 330
S2183
P
Q
E
P
L
V
I
S
P
I
N
T
R
A
R
Site 331
T2187
L
V
I
S
P
I
N
T
R
A
R
T
G
K
C
Site 332
T2191
P
I
N
T
R
A
R
T
G
K
C
E
S
L
C
Site 333
S2196
A
R
T
G
K
C
E
S
L
C
F
H
S
T
P
Site 334
T2202
E
S
L
C
F
H
S
T
P
I
I
Q
R
K
L
Site 335
S2220
L
P
E
A
P
G
L
S
P
L
S
T
E
P
K
Site 336
S2223
A
P
G
L
S
P
L
S
T
E
P
K
T
Q
K
Site 337
T2224
P
G
L
S
P
L
S
T
E
P
K
T
Q
K
L
Site 338
T2228
P
L
S
T
E
P
K
T
Q
K
L
S
N
K
K
Site 339
S2232
E
P
K
T
Q
K
L
S
N
K
K
G
S
N
T
Site 340
S2237
K
L
S
N
K
K
G
S
N
T
D
T
L
R
R
Site 341
T2241
K
K
G
S
N
T
D
T
L
R
R
V
L
L
T
Site 342
T2248
T
L
R
R
V
L
L
T
Q
A
K
N
Q
F
A
Site 343
T2259
N
Q
F
A
A
V
N
T
P
Q
K
E
T
S
Q
Site 344
S2265
N
T
P
Q
K
E
T
S
Q
I
D
G
P
S
L
Site 345
S2271
T
S
Q
I
D
G
P
S
L
N
N
T
Y
G
F
Site 346
T2275
D
G
P
S
L
N
N
T
Y
G
F
K
V
S
I
Site 347
T2298
L
H
E
I
Q
N
L
T
L
I
S
V
E
L
H
Site 348
T2332
F
Y
C
I
S
S
D
T
P
L
P
D
T
E
K
Site 349
T2337
S
D
T
P
L
P
D
T
E
K
T
E
L
T
G
Site 350
T2353
I
V
I
D
K
D
K
T
V
F
S
Q
D
I
R
Site 351
S2356
D
K
D
K
T
V
F
S
Q
D
I
R
Y
Q
T
Site 352
Y2361
V
F
S
Q
D
I
R
Y
Q
T
P
L
L
I
R
Site 353
T2363
S
Q
D
I
R
Y
Q
T
P
L
L
I
R
S
G
Site 354
Y2378
I
T
G
L
E
V
T
Y
A
A
D
E
K
A
L
Site 355
Y2404
D
P
D
I
L
L
G
Y
E
I
Q
M
H
S
W
Site 356
S2430
I
D
L
C
R
M
I
S
R
V
P
D
D
K
I
Site 357
Y2448
F
A
A
E
R
D
E
Y
G
S
Y
T
M
S
E
Site 358
S2450
A
E
R
D
E
Y
G
S
Y
T
M
S
E
I
N
Site 359
Y2451
E
R
D
E
Y
G
S
Y
T
M
S
E
I
N
I
Site 360
T2452
R
D
E
Y
G
S
Y
T
M
S
E
I
N
I
V
Site 361
S2454
E
Y
G
S
Y
T
M
S
E
I
N
I
V
G
R
Site 362
T2480
E
V
A
L
T
N
Y
T
F
E
N
V
S
F
H
Site 363
Y2512
F
D
N
K
T
D
L
Y
R
W
K
M
V
D
H
Site 364
Y2520
R
W
K
M
V
D
H
Y
V
S
R
V
R
G
N
Site 365
S2522
K
M
V
D
H
Y
V
S
R
V
R
G
N
L
Q
Site 366
S2559
L
H
V
L
T
R
G
S
Q
Y
R
V
E
S
M
Site 367
Y2561
V
L
T
R
G
S
Q
Y
R
V
E
S
M
M
L
Site 368
S2565
G
S
Q
Y
R
V
E
S
M
M
L
R
I
A
K
Site 369
T2580
P
M
N
Y
I
P
V
T
P
S
V
Q
Q
R
S
Site 370
S2582
N
Y
I
P
V
T
P
S
V
Q
Q
R
S
Q
M
Site 371
S2587
T
P
S
V
Q
Q
R
S
Q
M
R
A
P
Q
C
Site 372
S2603
P
L
I
M
E
P
E
S
R
F
Y
S
N
S
V
Site 373
Y2606
M
E
P
E
S
R
F
Y
S
N
S
V
L
V
L
Site 374
S2607
E
P
E
S
R
F
Y
S
N
S
V
L
V
L
D
Site 375
S2609
E
S
R
F
Y
S
N
S
V
L
V
L
D
F
Q
Site 376
Y2643
H
V
E
N
L
G
K
Y
D
E
F
K
F
G
C
Site 377
S2652
E
F
K
F
G
C
T
S
L
R
V
P
P
D
L
Site 378
Y2661
R
V
P
P
D
L
L
Y
Q
V
R
H
D
I
T
Site 379
T2668
Y
Q
V
R
H
D
I
T
V
S
P
N
G
V
A
Site 380
T2696
M
L
E
E
I
L
K
T
R
F
M
V
K
Q
S
Site 381
S2714
Y
K
Q
D
R
A
L
S
R
M
L
D
A
R
Q
Site 382
S2740
G
Y
T
S
A
N
F
S
G
R
M
P
C
I
E
Site 383
S2751
P
C
I
E
V
G
D
S
I
V
H
K
A
R
E
Site 384
T2759
I
V
H
K
A
R
E
T
L
E
R
A
I
K
L
Site 385
Y2779
K
W
G
A
R
V
V
Y
G
D
T
D
S
M
F
Site 386
S2797
K
G
A
T
K
E
Q
S
F
K
I
G
Q
E
I
Site 387
T2831
Y
L
P
C
V
L
Q
T
K
K
R
Y
V
G
Y
Site 388
Y2835
V
L
Q
T
K
K
R
Y
V
G
Y
M
Y
E
T
Site 389
T2857
F
D
A
K
G
I
E
T
V
R
R
D
S
C
P
Site 390
S2862
I
E
T
V
R
R
D
S
C
P
A
V
S
K
I
Site 391
S2867
R
D
S
C
P
A
V
S
K
I
L
E
R
S
L
Site 392
S2884
L
F
E
T
R
D
I
S
L
I
K
Q
Y
V
Q
Site 393
Y2889
D
I
S
L
I
K
Q
Y
V
Q
R
Q
C
M
K
Site 394
Y2913
D
F
I
F
A
K
E
Y
R
G
S
F
S
Y
K
Site 395
S2916
F
A
K
E
Y
R
G
S
F
S
Y
K
P
G
A
Site 396
S2918
K
E
Y
R
G
S
F
S
Y
K
P
G
A
C
V
Site 397
Y2919
E
Y
R
G
S
F
S
Y
K
P
G
A
C
V
P
Site 398
T2936
E
L
T
R
K
M
L
T
Y
D
R
R
S
E
P
Site 399
Y2937
L
T
R
K
M
L
T
Y
D
R
R
S
E
P
Q
Site 400
S2941
M
L
T
Y
D
R
R
S
E
P
Q
V
G
E
R
Site 401
T2977
V
E
V
L
Q
D
P
T
L
R
L
N
A
T
Y
Site 402
T2983
P
T
L
R
L
N
A
T
Y
Y
I
T
K
Q
I
Site 403
Y2984
T
L
R
L
N
A
T
Y
Y
I
T
K
Q
I
L
Site 404
Y2985
L
R
L
N
A
T
Y
Y
I
T
K
Q
I
L
P
Site 405
Y3009
G
I
D
V
F
S
W
Y
H
E
L
P
R
I
H
Site 406
T3019
L
P
R
I
H
K
A
T
S
S
S
R
S
E
P
Site 407
S3020
P
R
I
H
K
A
T
S
S
S
R
S
E
P
E
Site 408
S3021
R
I
H
K
A
T
S
S
S
R
S
E
P
E
G
Site 409
S3024
K
A
T
S
S
S
R
S
E
P
E
G
R
K
G
Site 410
T3032
E
P
E
G
R
K
G
T
I
S
Q
Y
F
T
T
Site 411
S3034
E
G
R
K
G
T
I
S
Q
Y
F
T
T
L
H
Site 412
Y3036
R
K
G
T
I
S
Q
Y
F
T
T
L
H
C
P
Site 413
S3059
G
I
C
S
K
C
R
S
Q
P
Q
H
V
A
V
Site 414
S3118
S
R
V
N
R
E
L
S
K
A
P
Y
L
R
Q
Site 415
Y3122
R
E
L
S
K
A
P
Y
L
R
Q
L
L
D
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation