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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SORBS3
Full Name:
Vinexin
Alias:
SCAM-1; SH3 domain protein 4; SH3-containing adapter molecule-1; SH3-containing adaptor molecule-1; SH3D4; SH3P3; Sorbin and SH3 domain containing 3; Sorbin and SH3 domain-containing protein 3; VINEX
Type:
Nuclear receptor co-regulator; Adaptor/scaffold; Adhesion
Mass (Da):
75329
Number AA:
671
UniProt ID:
O60504
International Prot ID:
IPI00419847
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005856
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005200
GO:0017166
PhosphoSite+
KinaseNET
Biological Process:
GO:0051496
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
Q
G
P
P
R
S
L
R
A
G
L
S
L
Site 2
S13
R
S
L
R
A
G
L
S
L
D
D
F
I
P
G
Site 3
S24
F
I
P
G
H
L
Q
S
H
I
G
S
S
S
R
Site 4
S28
H
L
Q
S
H
I
G
S
S
S
R
G
T
R
V
Site 5
S29
L
Q
S
H
I
G
S
S
S
R
G
T
R
V
P
Site 6
T33
I
G
S
S
S
R
G
T
R
V
P
V
I
R
N
Site 7
T45
I
R
N
G
G
S
N
T
L
N
F
Q
F
H
D
Site 8
T64
T
V
C
N
G
G
Y
T
P
R
R
D
A
S
Q
Site 9
S70
Y
T
P
R
R
D
A
S
Q
H
P
D
P
A
W
Site 10
Y78
Q
H
P
D
P
A
W
Y
Q
T
W
P
G
P
G
Site 11
T80
P
D
P
A
W
Y
Q
T
W
P
G
P
G
S
K
Site 12
S86
Q
T
W
P
G
P
G
S
K
P
S
A
S
T
K
Site 13
S89
P
G
P
G
S
K
P
S
A
S
T
K
I
P
A
Site 14
S91
P
G
S
K
P
S
A
S
T
K
I
P
A
S
Q
Site 15
S97
A
S
T
K
I
P
A
S
Q
H
T
Q
N
W
S
Site 16
T100
K
I
P
A
S
Q
H
T
Q
N
W
S
A
T
W
Site 17
T108
Q
N
W
S
A
T
W
T
K
D
S
K
R
R
D
Site 18
S111
S
A
T
W
T
K
D
S
K
R
R
D
K
R
W
Site 19
Y121
R
D
K
R
W
V
K
Y
E
G
I
G
P
V
D
Site 20
S130
G
I
G
P
V
D
E
S
G
M
P
I
A
P
R
Site 21
S138
G
M
P
I
A
P
R
S
S
V
D
R
P
R
D
Site 22
S139
M
P
I
A
P
R
S
S
V
D
R
P
R
D
W
Site 23
Y147
V
D
R
P
R
D
W
Y
R
R
M
F
Q
Q
I
Site 24
T166
P
D
L
Q
L
D
W
T
F
E
E
P
P
R
D
Site 25
T191
A
H
R
P
G
P
A
T
S
S
S
G
R
S
W
Site 26
S192
H
R
P
G
P
A
T
S
S
S
G
R
S
W
D
Site 27
S193
R
P
G
P
A
T
S
S
S
G
R
S
W
D
H
Site 28
S194
P
G
P
A
T
S
S
S
G
R
S
W
D
H
S
Site 29
S197
A
T
S
S
S
G
R
S
W
D
H
S
E
E
L
Site 30
S201
S
G
R
S
W
D
H
S
E
E
L
P
R
S
T
Site 31
S207
H
S
E
E
L
P
R
S
T
F
N
Y
R
P
G
Site 32
T208
S
E
E
L
P
R
S
T
F
N
Y
R
P
G
A
Site 33
Y211
L
P
R
S
T
F
N
Y
R
P
G
A
F
S
T
Site 34
S217
N
Y
R
P
G
A
F
S
T
V
L
Q
P
S
N
Site 35
T218
Y
R
P
G
A
F
S
T
V
L
Q
P
S
N
Q
Site 36
S268
D
D
P
G
E
K
P
S
Q
P
I
E
V
L
L
Site 37
T295
K
D
L
R
A
I
E
T
R
L
P
S
P
K
S
Site 38
S299
A
I
E
T
R
L
P
S
P
K
S
S
P
A
P
Site 39
S302
T
R
L
P
S
P
K
S
S
P
A
P
R
R
A
Site 40
S303
R
L
P
S
P
K
S
S
P
A
P
R
R
A
P
Site 41
S320
R
P
P
A
G
P
A
S
A
W
S
S
S
Y
P
Site 42
S323
A
G
P
A
S
A
W
S
S
S
Y
P
H
A
P
Site 43
S324
G
P
A
S
A
W
S
S
S
Y
P
H
A
P
Y
Site 44
S325
P
A
S
A
W
S
S
S
Y
P
H
A
P
Y
L
Site 45
Y326
A
S
A
W
S
S
S
Y
P
H
A
P
Y
L
G
Site 46
Y331
S
S
Y
P
H
A
P
Y
L
G
S
A
R
S
L
Site 47
S334
P
H
A
P
Y
L
G
S
A
R
S
L
S
P
H
Site 48
S337
P
Y
L
G
S
A
R
S
L
S
P
H
K
M
A
Site 49
S339
L
G
S
A
R
S
L
S
P
H
K
M
A
D
G
Site 50
S348
H
K
M
A
D
G
G
S
P
F
L
G
R
R
D
Site 51
Y358
L
G
R
R
D
F
V
Y
P
S
S
T
R
D
P
Site 52
S360
R
R
D
F
V
Y
P
S
S
T
R
D
P
S
A
Site 53
S361
R
D
F
V
Y
P
S
S
T
R
D
P
S
A
S
Site 54
T362
D
F
V
Y
P
S
S
T
R
D
P
S
A
S
N
Site 55
S366
P
S
S
T
R
D
P
S
A
S
N
G
G
G
S
Site 56
S368
S
T
R
D
P
S
A
S
N
G
G
G
S
P
A
Site 57
S373
S
A
S
N
G
G
G
S
P
A
R
R
E
E
K
Site 58
S395
K
F
D
F
Q
A
Q
S
P
K
E
L
T
L
Q
Site 59
Y408
L
Q
K
G
D
I
V
Y
I
H
K
E
V
D
K
Site 60
T450
P
K
P
I
K
P
P
T
Y
Q
V
L
E
Y
G
Site 61
Y451
K
P
I
K
P
P
T
Y
Q
V
L
E
Y
G
E
Site 62
Y463
Y
G
E
A
V
A
Q
Y
T
F
K
G
D
L
E
Site 63
T464
G
E
A
V
A
Q
Y
T
F
K
G
D
L
E
V
Site 64
S474
G
D
L
E
V
E
L
S
F
R
K
G
E
H
I
Site 65
Y492
R
K
V
N
E
N
W
Y
E
G
R
I
T
G
T
Site 66
T497
N
W
Y
E
G
R
I
T
G
T
G
R
Q
G
I
Site 67
S508
R
Q
G
I
F
P
A
S
Y
V
Q
V
S
R
E
Site 68
Y509
Q
G
I
F
P
A
S
Y
V
Q
V
S
R
E
P
Site 69
T529
D
D
G
P
Q
L
P
T
S
P
R
L
T
A
A
Site 70
S530
D
G
P
Q
L
P
T
S
P
R
L
T
A
A
A
Site 71
T534
L
P
T
S
P
R
L
T
A
A
A
R
S
A
R
Site 72
S539
R
L
T
A
A
A
R
S
A
R
H
P
S
S
P
Site 73
S544
A
R
S
A
R
H
P
S
S
P
S
A
L
R
S
Site 74
S545
R
S
A
R
H
P
S
S
P
S
A
L
R
S
P
Site 75
S547
A
R
H
P
S
S
P
S
A
L
R
S
P
A
D
Site 76
S551
S
S
P
S
A
L
R
S
P
A
D
P
T
D
L
Site 77
T556
L
R
S
P
A
D
P
T
D
L
G
G
Q
T
S
Site 78
T562
P
T
D
L
G
G
Q
T
S
P
R
R
T
G
F
Site 79
S563
T
D
L
G
G
Q
T
S
P
R
R
T
G
F
S
Site 80
T567
G
Q
T
S
P
R
R
T
G
F
S
F
P
T
Q
Site 81
S570
S
P
R
R
T
G
F
S
F
P
T
Q
E
P
R
Site 82
T573
R
T
G
F
S
F
P
T
Q
E
P
R
P
Q
T
Site 83
T580
T
Q
E
P
R
P
Q
T
Q
N
L
G
T
P
G
Site 84
T585
P
Q
T
Q
N
L
G
T
P
G
P
A
L
S
H
Site 85
S591
G
T
P
G
P
A
L
S
H
S
R
G
P
S
H
Site 86
S593
P
G
P
A
L
S
H
S
R
G
P
S
H
P
L
Site 87
S597
L
S
H
S
R
G
P
S
H
P
L
D
L
G
T
Site 88
T604
S
H
P
L
D
L
G
T
S
S
P
N
T
S
Q
Site 89
S605
H
P
L
D
L
G
T
S
S
P
N
T
S
Q
I
Site 90
S606
P
L
D
L
G
T
S
S
P
N
T
S
Q
I
H
Site 91
T609
L
G
T
S
S
P
N
T
S
Q
I
H
W
T
P
Site 92
S610
G
T
S
S
P
N
T
S
Q
I
H
W
T
P
Y
Site 93
T615
N
T
S
Q
I
H
W
T
P
Y
R
A
M
Y
Q
Site 94
Y621
W
T
P
Y
R
A
M
Y
Q
Y
R
P
Q
N
E
Site 95
Y623
P
Y
R
A
M
Y
Q
Y
R
P
Q
N
E
D
E
Site 96
T657
F
V
G
V
S
R
R
T
Q
K
F
G
T
F
P
Site 97
T662
R
R
T
Q
K
F
G
T
F
P
G
N
Y
V
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation