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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MGEA5
Full Name:
Bifunctional protein NCOAT
Alias:
Bifunctional protein NCOAT; EC 2.3.1.48; EC 3.2.1.52; KIAA0679; NCOAT; Nuclear cytoplasmic O-GlcNAcase and acetyltransferase
Type:
Enzyme, hydrolase
Mass (Da):
102915
Number AA:
916
UniProt ID:
O60502
International Prot ID:
IPI00477231
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0004563
GO:0004402
GO:0004415
PhosphoSite+
KinaseNET
Biological Process:
GO:0006516
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
V
Q
K
E
S
Q
A
T
L
E
E
R
E
S
E
Site 2
S15
A
T
L
E
E
R
E
S
E
L
S
S
N
P
A
Site 3
S18
E
E
R
E
S
E
L
S
S
N
P
A
A
S
A
Site 4
S19
E
R
E
S
E
L
S
S
N
P
A
A
S
A
G
Site 5
S24
L
S
S
N
P
A
A
S
A
G
A
S
L
E
P
Site 6
Y93
Q
K
W
E
L
N
T
Y
L
Y
A
P
K
D
D
Site 7
Y95
W
E
L
N
T
Y
L
Y
A
P
K
D
D
Y
K
Site 8
Y101
L
Y
A
P
K
D
D
Y
K
H
R
M
F
W
R
Site 9
Y111
R
M
F
W
R
E
M
Y
S
V
E
E
A
E
Q
Site 10
T121
E
E
A
E
Q
L
M
T
L
I
S
A
A
R
E
Site 11
S124
E
Q
L
M
T
L
I
S
A
A
R
E
Y
E
I
Site 12
T144
I
S
P
G
L
D
I
T
F
S
N
P
K
E
V
Site 13
S146
P
G
L
D
I
T
F
S
N
P
K
E
V
S
T
Site 14
T153
S
N
P
K
E
V
S
T
L
K
R
K
L
D
Q
Site 15
S162
K
R
K
L
D
Q
V
S
Q
F
G
C
R
S
F
Site 16
S190
A
D
K
E
V
F
S
S
F
A
H
A
Q
V
S
Site 17
S197
S
F
A
H
A
Q
V
S
I
T
N
E
I
Y
Q
Site 18
Y203
V
S
I
T
N
E
I
Y
Q
Y
L
G
E
P
E
Site 19
Y205
I
T
N
E
I
Y
Q
Y
L
G
E
P
E
T
F
Site 20
T211
Q
Y
L
G
E
P
E
T
F
L
F
C
P
T
E
Site 21
Y225
E
Y
C
G
T
F
C
Y
P
N
V
S
Q
S
P
Site 22
S229
T
F
C
Y
P
N
V
S
Q
S
P
Y
L
R
T
Site 23
S231
C
Y
P
N
V
S
Q
S
P
Y
L
R
T
V
G
Site 24
Y233
P
N
V
S
Q
S
P
Y
L
R
T
V
G
E
K
Site 25
T236
S
Q
S
P
Y
L
R
T
V
G
E
K
L
L
P
Site 26
S263
S
K
E
I
P
V
E
S
I
E
E
V
S
K
I
Site 27
S268
V
E
S
I
E
E
V
S
K
I
I
K
R
A
P
Site 28
Y286
D
N
I
H
A
N
D
Y
D
Q
K
R
L
F
L
Site 29
Y296
K
R
L
F
L
G
P
Y
K
G
R
S
T
E
L
Site 30
S300
L
G
P
Y
K
G
R
S
T
E
L
I
P
R
L
Site 31
T301
G
P
Y
K
G
R
S
T
E
L
I
P
R
L
K
Site 32
T312
P
R
L
K
G
V
L
T
N
P
N
C
E
F
E
Site 33
S348
K
D
V
V
M
T
D
S
E
D
S
T
V
S
I
Site 34
S351
V
M
T
D
S
E
D
S
T
V
S
I
Q
I
K
Site 35
T352
M
T
D
S
E
D
S
T
V
S
I
Q
I
K
L
Site 36
S354
D
S
E
D
S
T
V
S
I
Q
I
K
L
E
N
Site 37
S364
I
K
L
E
N
E
G
S
D
E
D
I
E
T
D
Site 38
T370
G
S
D
E
D
I
E
T
D
V
L
Y
S
P
Q
Site 39
Y374
D
I
E
T
D
V
L
Y
S
P
Q
M
A
L
K
Site 40
S375
I
E
T
D
V
L
Y
S
P
Q
M
A
L
K
L
Site 41
Y397
E
F
G
V
P
H
Q
Y
S
S
R
Q
V
A
H
Site 42
S398
F
G
V
P
H
Q
Y
S
S
R
Q
V
A
H
S
Site 43
S399
G
V
P
H
Q
Y
S
S
R
Q
V
A
H
S
G
Site 44
S405
S
S
R
Q
V
A
H
S
G
A
K
A
S
V
V
Site 45
S445
M
S
Q
G
A
A
L
S
G
E
P
T
T
L
T
Site 46
T449
A
A
L
S
G
E
P
T
T
L
T
K
E
E
E
Site 47
T452
S
G
E
P
T
T
L
T
K
E
E
E
K
K
Q
Site 48
T501
E
E
L
K
P
M
D
T
D
K
E
S
I
A
E
Site 49
S505
P
M
D
T
D
K
E
S
I
A
E
S
K
S
P
Site 50
S509
D
K
E
S
I
A
E
S
K
S
P
E
M
S
M
Site 51
S511
E
S
I
A
E
S
K
S
P
E
M
S
M
Q
E
Site 52
S515
E
S
K
S
P
E
M
S
M
Q
E
D
C
I
S
Site 53
Y548
G
P
N
E
K
P
L
Y
T
A
E
P
V
T
L
Site 54
T549
P
N
E
K
P
L
Y
T
A
E
P
V
T
L
E
Site 55
Y566
Q
L
L
A
D
L
F
Y
L
P
Y
E
H
G
P
Site 56
Y569
A
D
L
F
Y
L
P
Y
E
H
G
P
K
G
A
Site 57
S590
Q
W
L
R
A
N
S
S
V
V
S
V
N
C
K
Site 58
S593
R
A
N
S
S
V
V
S
V
N
C
K
G
K
D
Site 59
S601
V
N
C
K
G
K
D
S
E
K
I
E
E
W
R
Site 60
Y641
R
T
I
L
Y
D
M
Y
S
Y
V
W
D
I
K
Site 61
S665
V
Q
W
L
G
C
R
S
H
S
S
A
Q
F
L
Site 62
S668
L
G
C
R
S
H
S
S
A
Q
F
L
I
G
D
Site 63
T709
F
F
Q
P
P
P
L
T
P
T
S
K
V
Y
T
Site 64
S712
P
P
P
L
T
P
T
S
K
V
Y
T
I
R
P
Site 65
T716
T
P
T
S
K
V
Y
T
I
R
P
Y
F
P
K
Site 66
Y720
K
V
Y
T
I
R
P
Y
F
P
K
D
E
A
S
Site 67
Y729
P
K
D
E
A
S
V
Y
K
I
C
R
E
M
Y
Site 68
Y736
Y
K
I
C
R
E
M
Y
D
D
G
V
G
L
P
Site 69
S746
G
V
G
L
P
F
Q
S
Q
P
D
L
I
G
D
Site 70
Y805
I
P
F
M
Q
E
K
Y
T
K
P
N
G
D
K
Site 71
S815
P
N
G
D
K
E
L
S
E
A
E
K
I
M
L
Site 72
S823
E
A
E
K
I
M
L
S
F
H
E
E
Q
E
V
Site 73
T834
E
Q
E
V
L
P
E
T
F
L
A
N
F
P
S
Site 74
S855
H
K
K
V
T
D
P
S
V
A
K
S
M
M
A
Site 75
S859
T
D
P
S
V
A
K
S
M
M
A
C
L
L
S
Site 76
S867
M
M
A
C
L
L
S
S
L
K
A
N
G
S
R
Site 77
S873
S
S
L
K
A
N
G
S
R
G
A
F
C
E
V
Site 78
Y891
D
K
R
I
L
E
F
Y
S
K
L
G
C
F
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation