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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DOK2
Full Name:
Docking protein 2
Alias:
Docking protein 2, 56kDa; Dok-2; DokR; Dok-R; Dok-related protein; Downstream of tyrosine kinase 2; FRIP; IL-4 receptor interacting protein; P56(dok-2); P56dok-2
Type:
Adapter/scaffold protein
Mass (Da):
45379
Number AA:
412
UniProt ID:
O60496
International Prot ID:
IPI00022602
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0042802
GO:0005158
PhosphoSite+
KinaseNET
Biological Process:
GO:0007166
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y12
A
V
K
Q
G
F
L
Y
L
Q
Q
Q
Q
T
F
Site 2
T18
L
Y
L
Q
Q
Q
Q
T
F
G
K
K
W
R
R
Site 3
S29
K
W
R
R
F
G
A
S
L
Y
G
G
S
D
C
Site 4
Y31
R
R
F
G
A
S
L
Y
G
G
S
D
C
A
L
Site 5
S76
A
E
A
G
G
E
A
S
S
P
R
D
T
S
A
Site 6
S77
E
A
G
G
E
A
S
S
P
R
D
T
S
A
F
Site 7
T81
E
A
S
S
P
R
D
T
S
A
F
F
L
E
T
Site 8
S82
A
S
S
P
R
D
T
S
A
F
F
L
E
T
K
Site 9
S122
P
G
Q
R
K
E
L
S
G
P
E
G
K
Q
S
Site 10
S129
S
G
P
E
G
K
Q
S
R
P
C
M
E
E
N
Site 11
Y139
C
M
E
E
N
E
L
Y
S
S
A
V
T
V
G
Site 12
S140
M
E
E
N
E
L
Y
S
S
A
V
T
V
G
P
Site 13
S141
E
E
N
E
L
Y
S
S
A
V
T
V
G
P
H
Site 14
T144
E
L
Y
S
S
A
V
T
V
G
P
H
K
E
F
Site 15
T154
P
H
K
E
F
A
V
T
M
R
P
T
E
A
S
Site 16
T158
F
A
V
T
M
R
P
T
E
A
S
E
R
C
H
Site 17
S161
T
M
R
P
T
E
A
S
E
R
C
H
L
R
G
Site 18
S169
E
R
C
H
L
R
G
S
Y
T
L
R
A
G
E
Site 19
Y170
R
C
H
L
R
G
S
Y
T
L
R
A
G
E
S
Site 20
T171
C
H
L
R
G
S
Y
T
L
R
A
G
E
S
A
Site 21
S177
Y
T
L
R
A
G
E
S
A
L
E
L
W
G
G
Site 22
T189
W
G
G
P
E
P
G
T
Q
L
Y
D
W
P
Y
Site 23
Y192
P
E
P
G
T
Q
L
Y
D
W
P
Y
R
F
L
Site 24
Y196
T
Q
L
Y
D
W
P
Y
R
F
L
R
R
F
G
Site 25
T208
R
F
G
R
D
K
V
T
F
S
F
E
A
G
R
Site 26
S210
G
R
D
K
V
T
F
S
F
E
A
G
R
R
C
Site 27
S219
E
A
G
R
R
C
V
S
G
E
G
N
F
E
F
Site 28
S243
L
A
L
E
E
A
I
S
A
Q
K
N
A
A
P
Site 29
T252
Q
K
N
A
A
P
A
T
P
Q
P
Q
P
A
T
Site 30
T259
T
P
Q
P
Q
P
A
T
I
P
A
S
L
P
R
Site 31
S263
Q
P
A
T
I
P
A
S
L
P
R
P
D
S
P
Site 32
S269
A
S
L
P
R
P
D
S
P
Y
S
R
P
H
D
Site 33
Y271
L
P
R
P
D
S
P
Y
S
R
P
H
D
S
L
Site 34
S272
P
R
P
D
S
P
Y
S
R
P
H
D
S
L
P
Site 35
S277
P
Y
S
R
P
H
D
S
L
P
P
P
S
P
T
Site 36
S282
H
D
S
L
P
P
P
S
P
T
T
P
V
P
A
Site 37
T285
L
P
P
P
S
P
T
T
P
V
P
A
P
R
P
Site 38
Y299
P
R
G
Q
E
G
E
Y
A
V
P
F
D
A
V
Site 39
S309
P
F
D
A
V
A
R
S
L
G
K
N
F
R
G
Site 40
Y330
Q
L
L
A
D
P
L
Y
D
S
I
E
E
T
L
Site 41
S332
L
A
D
P
L
Y
D
S
I
E
E
T
L
P
P
Site 42
T336
L
Y
D
S
I
E
E
T
L
P
P
R
P
D
H
Site 43
Y345
P
P
R
P
D
H
I
Y
D
E
P
E
G
V
A
Site 44
S355
P
E
G
V
A
A
L
S
L
Y
D
S
P
Q
E
Site 45
Y357
G
V
A
A
L
S
L
Y
D
S
P
Q
E
P
R
Site 46
S359
A
A
L
S
L
Y
D
S
P
Q
E
P
R
G
E
Site 47
T373
E
A
W
R
R
Q
A
T
A
D
R
D
P
A
G
Site 48
S392
Q
P
A
G
Q
D
F
S
A
S
G
W
Q
P
G
Site 49
S394
A
G
Q
D
F
S
A
S
G
W
Q
P
G
T
E
Site 50
Y402
G
W
Q
P
G
T
E
Y
D
N
V
V
L
K
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation