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Updated November 2019
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Protein Info
Short Name:
TBC1D4
Full Name:
TBC1 domain family member 4
Alias:
Akt substrate of 160 kDa; AS160; DKFZp779C0666; KIAA0603; TBC1 domain family, member 4; TBC4; TBCD4
Type:
GTPase activating protein, Rab
Mass (Da):
146563
Number AA:
1298
UniProt ID:
O60343
International Prot ID:
IPI00220901
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005097
PhosphoSite+
KinaseNET
Biological Process:
GO:0032313
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S23
L
E
P
E
P
G
V
S
A
Q
P
G
P
G
K
Site 2
S32
Q
P
G
P
G
K
P
S
D
K
R
F
R
L
W
Site 3
Y40
D
K
R
F
R
L
W
Y
V
G
G
S
C
L
D
Site 4
T50
G
S
C
L
D
H
R
T
T
L
P
M
L
P
W
Site 5
S66
M
A
E
I
R
R
R
S
Q
K
P
E
A
G
G
Site 6
S87
R
E
V
I
L
V
L
S
A
P
F
L
R
C
V
Site 7
S102
P
A
P
G
A
G
A
S
G
G
T
S
P
S
A
Site 8
S106
A
G
A
S
G
G
T
S
P
S
A
T
Q
P
N
Site 9
S108
A
S
G
G
T
S
P
S
A
T
Q
P
N
P
A
Site 10
T110
G
G
T
S
P
S
A
T
Q
P
N
P
A
V
F
Site 11
Y138
H
N
S
H
D
L
T
Y
F
A
Y
L
I
K
A
Site 12
Y141
H
D
L
T
Y
F
A
Y
L
I
K
A
Q
P
D
Site 13
T162
A
C
H
V
F
R
A
T
D
P
S
Q
V
P
D
Site 14
S165
V
F
R
A
T
D
P
S
Q
V
P
D
V
I
S
Site 15
S172
S
Q
V
P
D
V
I
S
S
I
R
Q
L
S
K
Site 16
S173
Q
V
P
D
V
I
S
S
I
R
Q
L
S
K
A
Site 17
S178
I
S
S
I
R
Q
L
S
K
A
A
M
K
E
D
Site 18
Y197
K
D
N
E
D
A
F
Y
N
S
Q
K
F
E
V
Site 19
S220
T
H
K
K
A
P
S
S
L
I
D
D
C
M
E
Site 20
S262
L
E
V
V
V
P
G
S
P
G
D
C
L
P
E
Site 21
T274
L
P
E
E
A
D
G
T
D
T
H
L
G
L
P
Site 22
T276
E
E
A
D
G
T
D
T
H
L
G
L
P
A
G
Site 23
S285
L
G
L
P
A
G
A
S
Q
P
A
L
T
S
S
Site 24
T290
G
A
S
Q
P
A
L
T
S
S
R
V
C
F
P
Site 25
S291
A
S
Q
P
A
L
T
S
S
R
V
C
F
P
E
Site 26
S292
S
Q
P
A
L
T
S
S
R
V
C
F
P
E
R
Site 27
S304
P
E
R
I
L
E
D
S
G
F
D
E
Q
Q
E
Site 28
S314
D
E
Q
Q
E
F
R
S
R
C
S
S
V
T
G
Site 29
S317
Q
E
F
R
S
R
C
S
S
V
T
G
V
Q
R
Site 30
S318
E
F
R
S
R
C
S
S
V
T
G
V
Q
R
R
Site 31
T320
R
S
R
C
S
S
V
T
G
V
Q
R
R
V
H
Site 32
S330
Q
R
R
V
H
E
G
S
Q
K
S
Q
P
R
R
Site 33
S333
V
H
E
G
S
Q
K
S
Q
P
R
R
R
H
A
Site 34
S341
Q
P
R
R
R
H
A
S
A
P
S
H
V
Q
P
Site 35
S344
R
R
H
A
S
A
P
S
H
V
Q
P
S
D
S
Site 36
S349
A
P
S
H
V
Q
P
S
D
S
E
K
N
R
T
Site 37
S351
S
H
V
Q
P
S
D
S
E
K
N
R
T
M
L
Site 38
T356
S
D
S
E
K
N
R
T
M
L
F
Q
V
G
R
Site 39
S370
R
F
E
I
N
L
I
S
P
D
T
K
S
V
V
Site 40
S375
L
I
S
P
D
T
K
S
V
V
L
E
K
N
F
Site 41
S386
E
K
N
F
K
D
I
S
S
C
S
Q
G
I
K
Site 42
S387
K
N
F
K
D
I
S
S
C
S
Q
G
I
K
H
Site 43
S389
F
K
D
I
S
S
C
S
Q
G
I
K
H
V
D
Site 44
S405
F
G
F
I
C
R
E
S
P
E
P
G
L
S
Q
Site 45
S411
E
S
P
E
P
G
L
S
Q
Y
I
C
Y
V
F
Site 46
Y472
C
E
R
I
E
G
L
Y
P
P
R
A
K
L
V
Site 47
S485
L
V
I
Q
R
H
L
S
S
L
T
D
N
E
Q
Site 48
S486
V
I
Q
R
H
L
S
S
L
T
D
N
E
Q
A
Site 49
S506
V
Q
K
M
K
P
V
S
D
Q
E
E
N
E
L
Site 50
T528
L
C
E
A
K
Q
K
T
H
V
H
I
G
E
G
Site 51
S537
V
H
I
G
E
G
P
S
T
I
S
N
S
T
I
Site 52
T538
H
I
G
E
G
P
S
T
I
S
N
S
T
I
P
Site 53
S540
G
E
G
P
S
T
I
S
N
S
T
I
P
E
N
Site 54
S542
G
P
S
T
I
S
N
S
T
I
P
E
N
A
T
Site 55
S550
T
I
P
E
N
A
T
S
S
G
R
F
K
L
D
Site 56
S551
I
P
E
N
A
T
S
S
G
R
F
K
L
D
I
Site 57
S566
L
K
N
K
A
K
R
S
L
T
S
S
L
E
N
Site 58
T568
N
K
A
K
R
S
L
T
S
S
L
E
N
I
F
Site 59
S569
K
A
K
R
S
L
T
S
S
L
E
N
I
F
S
Site 60
S570
A
K
R
S
L
T
S
S
L
E
N
I
F
S
R
Site 61
S576
S
S
L
E
N
I
F
S
R
G
A
N
R
M
R
Site 62
S588
R
M
R
G
R
L
G
S
V
D
S
F
E
R
S
Site 63
S591
G
R
L
G
S
V
D
S
F
E
R
S
N
S
L
Site 64
S595
S
V
D
S
F
E
R
S
N
S
L
A
S
E
K
Site 65
S597
D
S
F
E
R
S
N
S
L
A
S
E
K
D
Y
Site 66
S600
E
R
S
N
S
L
A
S
E
K
D
Y
S
P
G
Site 67
Y604
S
L
A
S
E
K
D
Y
S
P
G
D
S
P
P
Site 68
S605
L
A
S
E
K
D
Y
S
P
G
D
S
P
P
G
Site 69
S609
K
D
Y
S
P
G
D
S
P
P
G
T
P
P
A
Site 70
T613
P
G
D
S
P
P
G
T
P
P
A
S
P
P
S
Site 71
S617
P
P
G
T
P
P
A
S
P
P
S
S
A
W
Q
Site 72
S620
T
P
P
A
S
P
P
S
S
A
W
Q
T
F
P
Site 73
S621
P
P
A
S
P
P
S
S
A
W
Q
T
F
P
E
Site 74
T625
P
P
S
S
A
W
Q
T
F
P
E
E
D
S
D
Site 75
S631
Q
T
F
P
E
E
D
S
D
S
P
Q
F
R
R
Site 76
S633
F
P
E
E
D
S
D
S
P
Q
F
R
R
R
A
Site 77
T642
Q
F
R
R
R
A
H
T
F
S
H
P
P
S
S
Site 78
S644
R
R
R
A
H
T
F
S
H
P
P
S
S
T
K
Site 79
S648
H
T
F
S
H
P
P
S
S
T
K
R
K
L
N
Site 80
S649
T
F
S
H
P
P
S
S
T
K
R
K
L
N
L
Site 81
T650
F
S
H
P
P
S
S
T
K
R
K
L
N
L
Q
Site 82
S666
G
R
A
Q
G
V
R
S
P
L
L
R
Q
S
S
Site 83
S672
R
S
P
L
L
R
Q
S
S
S
E
Q
C
S
N
Site 84
S673
S
P
L
L
R
Q
S
S
S
E
Q
C
S
N
L
Site 85
S674
P
L
L
R
Q
S
S
S
E
Q
C
S
N
L
S
Site 86
S678
Q
S
S
S
E
Q
C
S
N
L
S
S
V
R
R
Site 87
S681
S
E
Q
C
S
N
L
S
S
V
R
R
M
Y
K
Site 88
S682
E
Q
C
S
N
L
S
S
V
R
R
M
Y
K
E
Site 89
Y687
L
S
S
V
R
R
M
Y
K
E
S
N
S
S
S
Site 90
S690
V
R
R
M
Y
K
E
S
N
S
S
S
S
L
P
Site 91
S692
R
M
Y
K
E
S
N
S
S
S
S
L
P
S
L
Site 92
S693
M
Y
K
E
S
N
S
S
S
S
L
P
S
L
H
Site 93
S694
Y
K
E
S
N
S
S
S
S
L
P
S
L
H
T
Site 94
S695
K
E
S
N
S
S
S
S
L
P
S
L
H
T
S
Site 95
S698
N
S
S
S
S
L
P
S
L
H
T
S
F
S
A
Site 96
T701
S
S
L
P
S
L
H
T
S
F
S
A
P
S
F
Site 97
S702
S
L
P
S
L
H
T
S
F
S
A
P
S
F
T
Site 98
S704
P
S
L
H
T
S
F
S
A
P
S
F
T
A
P
Site 99
T709
S
F
S
A
P
S
F
T
A
P
S
F
L
K
S
Site 100
S712
A
P
S
F
T
A
P
S
F
L
K
S
F
Y
Q
Site 101
S716
T
A
P
S
F
L
K
S
F
Y
Q
N
S
G
R
Site 102
Y718
P
S
F
L
K
S
F
Y
Q
N
S
G
R
L
S
Site 103
S721
L
K
S
F
Y
Q
N
S
G
R
L
S
P
Q
Y
Site 104
S725
Y
Q
N
S
G
R
L
S
P
Q
Y
E
N
E
I
Site 105
Y728
S
G
R
L
S
P
Q
Y
E
N
E
I
R
Q
D
Site 106
T736
E
N
E
I
R
Q
D
T
A
S
E
S
S
D
G
Site 107
S738
E
I
R
Q
D
T
A
S
E
S
S
D
G
E
G
Site 108
T749
D
G
E
G
R
K
R
T
S
S
T
C
S
N
E
Site 109
S750
G
E
G
R
K
R
T
S
S
T
C
S
N
E
S
Site 110
S751
E
G
R
K
R
T
S
S
T
C
S
N
E
S
L
Site 111
T752
G
R
K
R
T
S
S
T
C
S
N
E
S
L
S
Site 112
S754
K
R
T
S
S
T
C
S
N
E
S
L
S
V
G
Site 113
S757
S
S
T
C
S
N
E
S
L
S
V
G
G
T
S
Site 114
S759
T
C
S
N
E
S
L
S
V
G
G
T
S
V
T
Site 115
T763
E
S
L
S
V
G
G
T
S
V
T
P
R
R
I
Site 116
S764
S
L
S
V
G
G
T
S
V
T
P
R
R
I
S
Site 117
T766
S
V
G
G
T
S
V
T
P
R
R
I
S
W
R
Site 118
S771
S
V
T
P
R
R
I
S
W
R
Q
R
I
F
L
Site 119
S782
R
I
F
L
R
V
A
S
P
M
N
K
S
P
S
Site 120
S787
V
A
S
P
M
N
K
S
P
S
A
M
Q
Q
Q
Site 121
S806
R
N
E
L
L
P
L
S
P
L
S
P
T
M
E
Site 122
S809
L
L
P
L
S
P
L
S
P
T
M
E
E
E
P
Site 123
T811
P
L
S
P
L
S
P
T
M
E
E
E
P
L
V
Site 124
S822
E
P
L
V
V
F
L
S
G
E
D
D
P
E
K
Site 125
S836
K
I
E
E
R
K
K
S
K
E
L
R
S
L
W
Site 126
S841
K
K
S
K
E
L
R
S
L
W
R
K
A
I
H
Site 127
S866
E
N
Q
K
L
E
A
S
R
D
E
L
Q
S
R
Site 128
S872
A
S
R
D
E
L
Q
S
R
K
V
K
L
D
Y
Site 129
Y879
S
R
K
V
K
L
D
Y
E
E
V
G
A
C
Q
Site 130
T892
C
Q
K
E
V
L
I
T
W
D
K
K
L
L
N
Site 131
T913
C
D
M
E
D
I
H
T
L
L
K
E
G
V
P
Site 132
S922
L
K
E
G
V
P
K
S
R
R
G
E
I
W
Q
Site 133
Y952
Q
Q
P
P
D
I
S
Y
K
E
L
L
K
Q
L
Site 134
T976
D
L
G
R
T
F
P
T
H
P
Y
F
S
V
Q
Site 135
Y979
R
T
F
P
T
H
P
Y
F
S
V
Q
L
G
P
Site 136
S981
F
P
T
H
P
Y
F
S
V
Q
L
G
P
G
Q
Site 137
Y1036
E
M
L
K
F
L
M
Y
D
L
G
F
R
K
Q
Site 138
Y1044
D
L
G
F
R
K
Q
Y
R
P
D
M
M
S
L
Site 139
Y1065
L
S
R
L
L
H
D
Y
H
R
D
L
Y
N
H
Site 140
Y1070
H
D
Y
H
R
D
L
Y
N
H
L
E
E
N
E
Site 141
S1079
H
L
E
E
N
E
I
S
P
S
L
Y
A
A
P
Site 142
S1081
E
E
N
E
I
S
P
S
L
Y
A
A
P
W
F
Site 143
T1129
S
L
L
S
S
Q
E
T
L
I
M
E
C
E
S
Site 144
T1153
N
T
L
P
D
M
N
T
S
E
M
E
K
I
I
Site 145
S1189
L
Q
D
E
L
Q
E
S
S
Y
S
C
E
D
S
Site 146
Y1191
D
E
L
Q
E
S
S
Y
S
C
E
D
S
E
T
Site 147
S1192
E
L
Q
E
S
S
Y
S
C
E
D
S
E
T
L
Site 148
S1196
S
S
Y
S
C
E
D
S
E
T
L
E
K
L
E
Site 149
T1198
Y
S
C
E
D
S
E
T
L
E
K
L
E
R
A
Site 150
S1207
E
K
L
E
R
A
N
S
Q
L
K
R
Q
N
M
Site 151
T1239
S
N
L
E
N
L
L
T
R
E
T
K
M
K
S
Site 152
T1242
E
N
L
L
T
R
E
T
K
M
K
S
L
I
R
Site 153
S1246
T
R
E
T
K
M
K
S
L
I
R
T
L
E
Q
Site 154
T1250
K
M
K
S
L
I
R
T
L
E
Q
E
K
M
A
Site 155
Y1258
L
E
Q
E
K
M
A
Y
Q
K
T
V
E
Q
L
Site 156
T1261
E
K
M
A
Y
Q
K
T
V
E
Q
L
R
K
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation