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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PIP5KG
Full Name:
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma
Alias:
Diphosphoinositide kinase; KIAA0589; LCCS3; Phosphatidylinositol-4-phosphate 5-kinase I-gamma; Phosphatidylinositol-4-phosphate 5-kinase type I gamma; Phosphatidylinositol-4-phosphate 5-kinase, type I, gamma; PI51C; PIP5Kgamma; PIP5KIgamma; PIPK I-gamma; PtdIns(4)P-5-kinase; PtdIns(4)P-5-kinase gamma; PtdInsPKIgamma; Type I PIP kinase
Type:
Kinase, lipid; Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.68
Mass (Da):
73260
Number AA:
668
UniProt ID:
O60331
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0016308
GO:0005524
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S45
A
A
P
T
E
V
L
S
M
T
A
Q
P
G
P
Site 2
T47
P
T
E
V
L
S
M
T
A
Q
P
G
P
G
H
Site 3
S66
G
H
R
G
V
D
A
S
G
E
T
T
Y
K
K
Site 4
T70
V
D
A
S
G
E
T
T
Y
K
K
T
T
S
S
Site 5
T74
G
E
T
T
Y
K
K
T
T
S
S
T
L
K
G
Site 6
S76
T
T
Y
K
K
T
T
S
S
T
L
K
G
A
I
Site 7
S117
V
E
S
I
F
F
P
S
E
G
S
N
L
T
P
Site 8
T123
P
S
E
G
S
N
L
T
P
A
H
H
F
Q
D
Site 9
T135
F
Q
D
F
R
F
K
T
Y
A
P
V
A
F
R
Site 10
Y136
Q
D
F
R
F
K
T
Y
A
P
V
A
F
R
Y
Site 11
Y155
F
G
I
R
P
D
D
Y
L
Y
S
L
C
N
E
Site 12
Y157
I
R
P
D
D
Y
L
Y
S
L
C
N
E
P
L
Site 13
S158
R
P
D
D
Y
L
Y
S
L
C
N
E
P
L
I
Site 14
S168
N
E
P
L
I
E
L
S
N
P
G
A
S
G
S
Site 15
S175
S
N
P
G
A
S
G
S
L
F
Y
V
T
S
D
Site 16
Y178
G
A
S
G
S
L
F
Y
V
T
S
D
D
E
F
Site 17
T189
D
D
E
F
I
I
K
T
V
M
H
K
E
A
E
Site 18
Y205
L
Q
K
L
L
P
G
Y
Y
M
N
L
N
Q
N
Site 19
T215
N
L
N
Q
N
P
R
T
L
L
P
K
F
Y
G
Site 20
Y224
L
P
K
F
Y
G
L
Y
C
V
Q
S
G
G
K
Site 21
Y259
F
D
L
K
G
S
T
Y
K
R
R
A
S
K
K
Site 22
S264
S
T
Y
K
R
R
A
S
K
K
E
K
E
K
S
Site 23
S271
S
K
K
E
K
E
K
S
F
P
T
Y
K
D
L
Site 24
Y275
K
E
K
S
F
P
T
Y
K
D
L
D
F
M
Q
Site 25
S342
A
Q
G
A
Q
S
T
S
D
E
K
R
P
V
G
Site 26
Y354
P
V
G
Q
K
A
L
Y
S
T
A
M
E
S
I
Site 27
S355
V
G
Q
K
A
L
Y
S
T
A
M
E
S
I
Q
Site 28
S373
A
R
G
E
A
I
E
S
D
D
T
M
G
G
I
Site 29
T376
E
A
I
E
S
D
D
T
M
G
G
I
P
A
V
Site 30
T422
A
L
V
H
D
G
D
T
V
S
V
H
R
P
S
Site 31
S424
V
H
D
G
D
T
V
S
V
H
R
P
S
F
Y
Site 32
S429
T
V
S
V
H
R
P
S
F
Y
A
E
R
F
F
Site 33
Y431
S
V
H
R
P
S
F
Y
A
E
R
F
F
K
F
Site 34
T442
F
F
K
F
M
S
N
T
V
F
R
K
N
S
S
Site 35
S448
N
T
V
F
R
K
N
S
S
L
K
S
S
P
S
Site 36
S449
T
V
F
R
K
N
S
S
L
K
S
S
P
S
K
Site 37
S452
R
K
N
S
S
L
K
S
S
P
S
K
K
G
R
Site 38
S453
K
N
S
S
L
K
S
S
P
S
K
K
G
R
G
Site 39
S455
S
S
L
K
S
S
P
S
K
K
G
R
G
G
A
Site 40
S476
L
G
P
T
A
A
F
S
A
S
Q
I
P
S
E
Site 41
S478
P
T
A
A
F
S
A
S
Q
I
P
S
E
R
E
Site 42
S482
F
S
A
S
Q
I
P
S
E
R
E
E
A
Q
Y
Site 43
Y489
S
E
R
E
E
A
Q
Y
D
L
R
G
A
R
S
Site 44
S496
Y
D
L
R
G
A
R
S
Y
P
T
L
E
D
E
Site 45
Y497
D
L
R
G
A
R
S
Y
P
T
L
E
D
E
G
Site 46
T499
R
G
A
R
S
Y
P
T
L
E
D
E
G
R
P
Site 47
T512
R
P
D
L
L
P
C
T
P
P
S
F
E
E
A
Site 48
S532
A
T
T
L
S
S
T
S
L
S
I
P
E
R
S
Site 49
S534
T
L
S
S
T
S
L
S
I
P
E
R
S
P
S
Site 50
S539
S
L
S
I
P
E
R
S
P
S
E
T
S
E
Q
Site 51
S541
S
I
P
E
R
S
P
S
E
T
S
E
Q
P
R
Site 52
T543
P
E
R
S
P
S
E
T
S
E
Q
P
R
Y
R
Site 53
S544
E
R
S
P
S
E
T
S
E
Q
P
R
Y
R
R
Site 54
Y549
E
T
S
E
Q
P
R
Y
R
R
R
T
Q
S
S
Site 55
T553
Q
P
R
Y
R
R
R
T
Q
S
S
G
Q
D
G
Site 56
S555
R
Y
R
R
R
T
Q
S
S
G
Q
D
G
R
P
Site 57
S556
Y
R
R
R
T
Q
S
S
G
Q
D
G
R
P
Q
Site 58
T576
E
E
D
L
Q
Q
I
T
V
Q
V
E
P
A
C
Site 59
S600
E
D
A
G
V
E
A
S
P
A
G
A
S
A
A
Site 60
S625
D
E
E
G
A
P
A
S
Q
A
S
D
E
E
D
Site 61
T636
D
E
E
D
A
P
A
T
D
I
Y
F
P
T
D
Site 62
Y639
D
A
P
A
T
D
I
Y
F
P
T
D
E
R
S
Site 63
T642
A
T
D
I
Y
F
P
T
D
E
R
S
W
V
Y
Site 64
Y649
T
D
E
R
S
W
V
Y
S
P
L
H
Y
S
A
Site 65
S650
D
E
R
S
W
V
Y
S
P
L
H
Y
S
A
Q
Site 66
S655
V
Y
S
P
L
H
Y
S
A
Q
A
P
P
A
S
Site 67
S662
S
A
Q
A
P
P
A
S
D
G
E
S
D
T
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation