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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Adenylate cyclase 3
Full Name:
Adenylate cyclase type 3
Alias:
ATP pyrophosphate-lyase 3;Adenylate cyclase type III;Adenylate cyclase, olfactive type;Adenylyl cyclase 3
Type:
Enzyme, cyclic nucleotide synthesis
Mass (Da):
128960
Number AA:
1144
UniProt ID:
O60266
International Prot ID:
IPI00028513
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005516
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0007189
GO:0034199
GO:0006171
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
P
R
N
Q
G
F
S
E
P
E
Y
S
A
E
Site 2
Y12
Q
G
F
S
E
P
E
Y
S
A
E
Y
S
A
E
Site 3
S13
G
F
S
E
P
E
Y
S
A
E
Y
S
A
E
Y
Site 4
S17
P
E
Y
S
A
E
Y
S
A
E
Y
S
V
S
L
Site 5
Y20
S
A
E
Y
S
A
E
Y
S
V
S
L
P
S
D
Site 6
S21
A
E
Y
S
A
E
Y
S
V
S
L
P
S
D
P
Site 7
S23
Y
S
A
E
Y
S
V
S
L
P
S
D
P
D
R
Site 8
S26
E
Y
S
V
S
L
P
S
D
P
D
R
G
V
G
Site 9
T35
P
D
R
G
V
G
R
T
H
E
I
S
V
R
N
Site 10
S39
V
G
R
T
H
E
I
S
V
R
N
S
G
S
C
Site 11
S43
H
E
I
S
V
R
N
S
G
S
C
L
C
L
P
Site 12
S61
R
L
T
F
V
P
E
S
L
E
N
L
Y
Q
T
Site 13
Y66
P
E
S
L
E
N
L
Y
Q
T
Y
F
K
R
Q
Site 14
Y69
L
E
N
L
Y
Q
T
Y
F
K
R
Q
R
H
E
Site 15
S166
F
A
R
A
H
A
A
S
D
T
V
G
W
Q
V
Site 16
T208
H
T
L
V
L
G
V
T
V
A
Q
Q
Q
Q
E
Site 17
Y245
A
V
G
I
M
S
Y
Y
M
A
D
R
K
H
R
Site 18
S261
A
F
L
E
A
R
Q
S
L
E
V
K
M
N
L
Site 19
S281
Q
Q
E
N
L
M
L
S
I
L
P
K
H
V
A
Site 20
S300
K
D
M
K
K
D
E
S
Q
K
D
Q
Q
Q
F
Site 21
Y379
C
I
C
G
L
P
D
Y
R
E
D
H
A
V
C
Site 22
S399
L
A
M
V
E
A
I
S
Y
V
R
E
K
T
K
Site 23
Y400
A
M
V
E
A
I
S
Y
V
R
E
K
T
K
T
Site 24
T405
I
S
Y
V
R
E
K
T
K
T
G
V
D
M
R
Site 25
T407
Y
V
R
E
K
T
K
T
G
V
D
M
R
V
G
Site 26
T417
D
M
R
V
G
V
H
T
G
T
V
L
G
G
V
Site 27
T419
R
V
G
V
H
T
G
T
V
L
G
G
V
L
G
Site 28
Y432
L
G
Q
K
R
W
Q
Y
D
V
W
S
T
D
V
Site 29
T440
D
V
W
S
T
D
V
T
V
A
N
K
M
E
A
Site 30
S459
G
R
V
H
I
S
Q
S
T
M
D
C
L
K
G
Site 31
S477
V
E
P
G
D
G
G
S
R
C
D
Y
L
E
E
Site 32
Y481
D
G
G
S
R
C
D
Y
L
E
E
K
G
I
E
Site 33
Y490
E
E
K
G
I
E
T
Y
L
I
I
A
S
K
P
Site 34
T502
S
K
P
E
V
K
K
T
A
T
Q
N
G
L
N
Site 35
S511
T
Q
N
G
L
N
G
S
A
L
P
N
G
A
P
Site 36
S520
L
P
N
G
A
P
A
S
S
K
S
S
S
P
A
Site 37
S521
P
N
G
A
P
A
S
S
K
S
S
S
P
A
L
Site 38
S523
G
A
P
A
S
S
K
S
S
S
P
A
L
I
E
Site 39
S524
A
P
A
S
S
K
S
S
S
P
A
L
I
E
T
Site 40
S525
P
A
S
S
K
S
S
S
P
A
L
I
E
T
K
Site 41
T531
S
S
P
A
L
I
E
T
K
E
P
N
G
S
A
Site 42
S537
E
T
K
E
P
N
G
S
A
H
S
S
G
S
T
Site 43
S540
E
P
N
G
S
A
H
S
S
G
S
T
S
E
K
Site 44
S541
P
N
G
S
A
H
S
S
G
S
T
S
E
K
P
Site 45
S543
G
S
A
H
S
S
G
S
T
S
E
K
P
E
E
Site 46
S545
A
H
S
S
G
S
T
S
E
K
P
E
E
Q
D
Site 47
S559
D
A
Q
A
D
N
P
S
F
P
N
P
R
R
R
Site 48
S580
A
D
R
V
V
D
A
S
E
D
E
H
E
L
N
Site 49
S599
E
A
L
L
E
R
E
S
A
Q
V
V
K
K
R
Site 50
T608
Q
V
V
K
K
R
N
T
F
L
L
S
M
R
F
Site 51
S612
K
R
N
T
F
L
L
S
M
R
F
M
D
P
E
Site 52
S625
P
E
M
E
T
R
Y
S
V
E
K
E
K
Q
S
Site 53
S632
S
V
E
K
E
K
Q
S
G
A
A
F
S
C
S
Site 54
T696
K
K
L
V
A
F
S
T
W
I
D
R
T
R
W
Site 55
Y730
D
M
L
S
C
L
Q
Y
Y
T
G
P
S
N
A
Site 56
Y731
M
L
S
C
L
Q
Y
Y
T
G
P
S
N
A
T
Site 57
S746
A
G
M
E
T
E
G
S
C
L
E
N
P
K
Y
Site 58
Y753
S
C
L
E
N
P
K
Y
Y
N
Y
V
A
V
L
Site 59
Y802
W
R
P
V
F
D
E
Y
D
H
K
R
F
R
E
Site 60
S838
D
R
L
P
L
V
P
S
K
Y
S
M
T
V
M
Site 61
Y855
L
M
M
L
S
F
Y
Y
F
S
R
H
V
E
K
Site 62
Y882
H
D
Q
K
E
R
V
Y
E
M
R
R
W
N
E
Site 63
T893
R
W
N
E
A
L
V
T
N
M
L
P
E
H
V
Site 64
S907
V
A
R
H
F
L
G
S
K
K
R
D
E
E
L
Site 65
Y915
K
K
R
D
E
E
L
Y
S
Q
T
Y
D
E
I
Site 66
S916
K
R
D
E
E
L
Y
S
Q
T
Y
D
E
I
G
Site 67
Y919
E
E
L
Y
S
Q
T
Y
D
E
I
G
V
M
F
Site 68
Y936
L
P
N
F
A
D
F
Y
T
E
E
S
I
N
N
Site 69
T937
P
N
F
A
D
F
Y
T
E
E
S
I
N
N
G
Site 70
S940
A
D
F
Y
T
E
E
S
I
N
N
G
G
I
E
Site 71
S961
E
I
I
S
D
F
D
S
L
L
D
N
P
K
F
Site 72
T972
N
P
K
F
R
V
I
T
K
I
K
T
I
G
S
Site 73
S979
T
K
I
K
T
I
G
S
T
Y
M
A
A
S
G
Site 74
T988
Y
M
A
A
S
G
V
T
P
D
V
N
T
N
G
Site 75
T993
G
V
T
P
D
V
N
T
N
G
F
A
S
S
N
Site 76
S1005
S
S
N
K
E
D
K
S
E
R
E
R
W
Q
H
Site 77
T1026
F
A
L
A
M
K
D
T
L
T
N
I
N
N
Q
Site 78
T1028
L
A
M
K
D
T
L
T
N
I
N
N
Q
S
F
Site 79
S1034
L
T
N
I
N
N
Q
S
F
N
N
F
M
L
R
Site 80
Y1061
I
G
A
R
K
P
H
Y
D
I
W
G
N
T
V
Site 81
S1076
N
V
A
S
R
M
E
S
T
G
V
M
G
N
I
Site 82
Y1096
T
Q
V
I
L
R
E
Y
G
F
R
F
V
R
R
Site 83
T1116
K
G
K
G
E
L
L
T
F
F
L
K
G
R
D
Site 84
T1127
K
G
R
D
K
L
A
T
F
P
N
G
P
S
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation