PhosphoNET

           
Protein Info 
   
Short Name:  Spry2
Full Name:  Protein sprouty homolog 2
Alias:  hSPRY2; sprouty 2; Sprouty homolog 2; Sprouty2; Spry-2; SPY2
Type:  Inhibitor protein; Adaptor/scaffold
Mass (Da):  34688
Number AA:  315
UniProt ID:  O43597
International Prot ID:  IPI00012913
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005829  GO:0005874  GO:0005886 Uniprot OncoNet
Molecular Function:      PhosphoSite+ KinaseNET
Biological Process:  GO:0007267  GO:0007165   Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S7_MEARAQSGNGSQPL
Site 2S11RAQSGNGSQPLLQTP
Site 3T17GSQPLLQTPRDGGRQ
Site 4T35PDPRDALTQQVHVLS
Site 5S42TQQVHVLSLDQIRAI
Site 6T52QIRAIRNTNEYTEGP
Site 7Y55AIRNTNEYTEGPTVV
Site 8T56IRNTNEYTEGPTVVP
Site 9T60NEYTEGPTVVPRPGL
Site 10S74LKPAPRPSTQHKHER
Site 11T75KPAPRPSTQHKHERL
Site 12S97QPPRLQHSQVHSSAR
Site 13S101LQHSQVHSSARAPLS
Site 14S102QHSQVHSSARAPLSR
Site 15S108SSARAPLSRSISTVS
Site 16S110ARAPLSRSISTVSSG
Site 17S112APLSRSISTVSSGSR
Site 18T113PLSRSISTVSSGSRS
Site 19S115SRSISTVSSGSRSST
Site 20S116RSISTVSSGSRSSTR
Site 21S118ISTVSSGSRSSTRTS
Site 22S120TVSSGSRSSTRTSTS
Site 23S121VSSGSRSSTRTSTSS
Site 24T122SSGSRSSTRTSTSSS
Site 25T124GSRSSTRTSTSSSSS
Site 26S125SRSSTRTSTSSSSSE
Site 27T126RSSTRTSTSSSSSEQ
Site 28S127SSTRTSTSSSSSEQR
Site 29S128STRTSTSSSSSEQRL
Site 30S129TRTSTSSSSSEQRLL
Site 31S130RTSTSSSSSEQRLLG
Site 32S131TSTSSSSSEQRLLGS
Site 33S138SEQRLLGSSFSSGPV
Site 34S139EQRLLGSSFSSGPVA
Site 35S141RLLGSSFSSGPVADG
Site 36S142LLGSSFSSGPVADGI
Site 37S156IIRVQPKSELKPGEL
Site 38S167PGELKPLSKEDLGLH
Site 39Y176EDLGLHAYRCEDCGK
Site 40T190KCKCKECTYPRPLPS
Site 41Y191CKCKECTYPRPLPSD
Site 42S197TYPRPLPSDWICDKQ
Site 43Y227CCVKGLFYHCSNDDE
Site 44Y269FLPCLWCYLPAKGCL
Site 45Y283LKLCQGCYDRVNRPG
Site 46T305TVCCKVPTVPPRNFE
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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