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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EIF4G3
Full Name:
Eukaryotic translation initiation factor 4 gamma 3
Alias:
EIF4G 3; EIF-4G 3; EIF-4-gamma 3; EIF-4-gamma II; EIF4GII; Eukaryotic translation initiation factor 4 gamma, 3; IF4G3
Type:
Protein synthesis protein
Mass (Da):
176652
Number AA:
1585
UniProt ID:
O43432
International Prot ID:
IPI00646377
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016281
Uniprot
OncoNet
Molecular Function:
GO:0000339
GO:0005515
GO:0003743
PhosphoSite+
KinaseNET
Biological Process:
GO:0016070
GO:0044419
GO:0006446
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S3
_
_
_
_
_
M
N
S
Q
P
Q
T
R
S
P
Site 2
T7
_
M
N
S
Q
P
Q
T
R
S
P
F
F
Q
R
Site 3
S9
N
S
Q
P
Q
T
R
S
P
F
F
Q
R
P
Q
Site 4
T23
Q
I
Q
P
P
R
A
T
I
P
N
S
S
P
S
Site 5
S27
P
R
A
T
I
P
N
S
S
P
S
I
R
P
G
Site 6
S28
R
A
T
I
P
N
S
S
P
S
I
R
P
G
A
Site 7
S30
T
I
P
N
S
S
P
S
I
R
P
G
A
Q
T
Site 8
T37
S
I
R
P
G
A
Q
T
P
T
A
V
Y
Q
A
Site 9
Y58
V
N
H
L
P
M
P
Y
P
V
P
Q
G
P
Q
Site 10
Y66
P
V
P
Q
G
P
Q
Y
C
I
P
Q
Y
R
H
Site 11
Y71
P
Q
Y
C
I
P
Q
Y
R
H
S
G
P
P
Y
Site 12
S74
C
I
P
Q
Y
R
H
S
G
P
P
Y
V
G
P
Site 13
Y78
Y
R
H
S
G
P
P
Y
V
G
P
P
Q
Q
Y
Site 14
Y85
Y
V
G
P
P
Q
Q
Y
P
V
Q
P
P
G
P
Site 15
Y96
P
P
G
P
G
P
F
Y
P
G
P
G
P
G
D
Site 16
Y108
P
G
D
F
P
N
A
Y
G
T
P
F
Y
P
S
Site 17
T110
D
F
P
N
A
Y
G
T
P
F
Y
P
S
Q
P
Site 18
Y113
N
A
Y
G
T
P
F
Y
P
S
Q
P
V
Y
Q
Site 19
S115
Y
G
T
P
F
Y
P
S
Q
P
V
Y
Q
S
A
Site 20
T141
P
A
K
R
E
K
K
T
I
R
I
R
D
P
N
Site 21
T155
N
Q
G
G
K
D
I
T
E
E
I
M
S
G
G
Site 22
S160
D
I
T
E
E
I
M
S
G
G
G
S
R
N
P
Site 23
S164
E
I
M
S
G
G
G
S
R
N
P
T
P
P
I
Site 24
T168
G
G
G
S
R
N
P
T
P
P
I
G
R
P
T
Site 25
T175
T
P
P
I
G
R
P
T
S
T
P
T
P
P
Q
Site 26
S176
P
P
I
G
R
P
T
S
T
P
T
P
P
Q
Q
Site 27
T177
P
I
G
R
P
T
S
T
P
T
P
P
Q
Q
L
Site 28
T179
G
R
P
T
S
T
P
T
P
P
Q
Q
L
P
S
Site 29
S186
T
P
P
Q
Q
L
P
S
Q
V
P
E
H
S
P
Site 30
S192
P
S
Q
V
P
E
H
S
P
V
V
Y
G
T
V
Site 31
Y196
P
E
H
S
P
V
V
Y
G
T
V
E
S
A
H
Site 32
T211
L
A
A
S
T
P
V
T
A
A
S
D
Q
K
Q
Site 33
S214
S
T
P
V
T
A
A
S
D
Q
K
Q
E
E
K
Site 34
S230
K
P
D
P
V
L
K
S
P
S
P
V
L
R
L
Site 35
S232
D
P
V
L
K
S
P
S
P
V
L
R
L
V
L
Site 36
S240
P
V
L
R
L
V
L
S
G
E
K
K
E
Q
E
Site 37
S251
K
E
Q
E
G
Q
T
S
E
T
T
A
I
V
S
Site 38
S267
A
E
L
P
L
P
P
S
P
T
T
V
S
S
V
Site 39
T270
P
L
P
P
S
P
T
T
V
S
S
V
A
R
S
Site 40
S272
P
P
S
P
T
T
V
S
S
V
A
R
S
T
I
Site 41
S273
P
S
P
T
T
V
S
S
V
A
R
S
T
I
A
Site 42
T283
R
S
T
I
A
A
P
T
S
S
A
L
S
S
Q
Site 43
S284
S
T
I
A
A
P
T
S
S
A
L
S
S
Q
P
Site 44
S288
A
P
T
S
S
A
L
S
S
Q
P
I
F
T
T
Site 45
S289
P
T
S
S
A
L
S
S
Q
P
I
F
T
T
A
Site 46
S304
I
D
D
R
C
E
L
S
S
P
R
E
D
T
I
Site 47
S305
D
D
R
C
E
L
S
S
P
R
E
D
T
I
P
Site 48
T310
L
S
S
P
R
E
D
T
I
P
I
P
S
L
T
Site 49
S315
E
D
T
I
P
I
P
S
L
T
S
C
T
E
T
Site 50
T317
T
I
P
I
P
S
L
T
S
C
T
E
T
S
D
Site 51
T322
S
L
T
S
C
T
E
T
S
D
P
L
P
T
N
Site 52
S341
D
I
C
K
K
P
C
S
V
A
P
N
D
I
P
Site 53
S351
P
N
D
I
P
L
V
S
S
T
N
L
I
N
E
Site 54
S367
N
G
V
S
E
K
L
S
A
T
E
S
I
V
E
Site 55
T369
V
S
E
K
L
S
A
T
E
S
I
V
E
I
V
Site 56
S371
E
K
L
S
A
T
E
S
I
V
E
I
V
K
Q
Site 57
T410
P
A
P
I
T
P
S
T
V
P
S
F
P
P
T
Site 58
S413
I
T
P
S
T
V
P
S
F
P
P
T
P
P
T
Site 59
T417
T
V
P
S
F
P
P
T
P
P
T
P
P
A
S
Site 60
T420
S
F
P
P
T
P
P
T
P
P
A
S
P
P
H
Site 61
S424
T
P
P
T
P
P
A
S
P
P
H
T
P
V
I
Site 62
S441
A
A
A
T
T
V
S
S
P
S
A
A
I
T
V
Site 63
T447
S
S
P
S
A
A
I
T
V
Q
R
V
L
E
E
Site 64
S457
R
V
L
E
E
D
E
S
I
R
T
C
L
S
E
Site 65
T460
E
E
D
E
S
I
R
T
C
L
S
E
D
A
K
Site 66
S463
E
S
I
R
T
C
L
S
E
D
A
K
E
I
Q
Site 67
S487
Q
T
E
E
I
L
D
S
Q
N
L
N
S
R
R
Site 68
S492
L
D
S
Q
N
L
N
S
R
R
S
P
V
P
A
Site 69
S495
Q
N
L
N
S
R
R
S
P
V
P
A
Q
I
A
Site 70
T508
I
A
I
T
V
P
K
T
W
K
K
P
K
D
R
Site 71
T518
K
P
K
D
R
T
R
T
T
E
E
M
L
E
A
Site 72
T519
P
K
D
R
T
R
T
T
E
E
M
L
E
A
E
Site 73
S536
L
K
A
E
E
E
L
S
I
D
K
V
L
E
S
Site 74
S543
S
I
D
K
V
L
E
S
E
Q
D
K
M
S
Q
Site 75
S549
E
S
E
Q
D
K
M
S
Q
G
F
H
P
E
R
Site 76
S559
F
H
P
E
R
D
P
S
D
L
K
K
V
K
A
Site 77
S583
P
V
R
N
G
A
E
S
V
S
E
G
E
G
I
Site 78
S585
R
N
G
A
E
S
V
S
E
G
E
G
I
D
A
Site 79
S594
G
E
G
I
D
A
N
S
G
S
T
D
S
S
G
Site 80
S596
G
I
D
A
N
S
G
S
T
D
S
S
G
D
G
Site 81
S599
A
N
S
G
S
T
D
S
S
G
D
G
V
T
F
Site 82
S600
N
S
G
S
T
D
S
S
G
D
G
V
T
F
P
Site 83
T605
D
S
S
G
D
G
V
T
F
P
F
K
P
E
S
Site 84
S612
T
F
P
F
K
P
E
S
W
K
P
T
D
T
E
Site 85
T616
K
P
E
S
W
K
P
T
D
T
E
G
K
K
Q
Site 86
T618
E
S
W
K
P
T
D
T
E
G
K
K
Q
Y
D
Site 87
Y624
D
T
E
G
K
K
Q
Y
D
R
E
F
L
L
D
Site 88
T678
L
P
R
G
P
D
F
T
P
A
F
A
D
F
G
Site 89
T688
F
A
D
F
G
R
Q
T
P
G
G
R
G
V
P
Site 90
S701
V
P
L
L
N
V
G
S
R
R
S
Q
P
G
Q
Site 91
S704
L
N
V
G
S
R
R
S
Q
P
G
Q
R
R
E
Site 92
T717
R
E
P
R
K
I
I
T
V
S
V
K
E
D
V
Site 93
S719
P
R
K
I
I
T
V
S
V
K
E
D
V
H
L
Site 94
S736
A
E
N
A
W
K
P
S
Q
K
R
D
S
Q
A
Site 95
S741
K
P
S
Q
K
R
D
S
Q
A
D
D
P
E
N
Site 96
T751
D
D
P
E
N
I
K
T
Q
E
L
F
R
K
V
Site 97
T766
R
S
I
L
N
K
L
T
P
Q
M
F
N
Q
L
Site 98
T784
V
S
G
L
T
V
D
T
E
E
R
L
K
G
V
Site 99
S804
E
K
A
I
D
E
P
S
F
S
V
A
Y
A
N
Site 100
S889
K
D
K
A
R
R
R
S
I
G
N
I
K
F
I
Site 101
S925
L
K
N
H
D
E
E
S
L
E
C
L
C
R
L
Site 102
Y952
A
K
P
R
M
D
Q
Y
F
N
Q
M
E
K
I
Site 103
T965
K
I
V
K
E
R
K
T
S
S
R
I
R
F
M
Site 104
S966
I
V
K
E
R
K
T
S
S
R
I
R
F
M
L
Site 105
S967
V
K
E
R
K
T
S
S
R
I
R
F
M
L
Q
Site 106
S986
L
R
L
C
N
W
V
S
R
R
A
D
Q
G
P
Site 107
T995
R
A
D
Q
G
P
K
T
I
E
Q
I
H
K
E
Site 108
S1044
T
V
Q
G
A
K
N
S
R
V
L
D
P
S
K
Site 109
S1050
N
S
R
V
L
D
P
S
K
F
L
K
I
T
K
Site 110
S1074
V
P
K
A
Q
L
G
S
W
G
K
G
S
S
G
Site 111
S1079
L
G
S
W
G
K
G
S
S
G
G
A
K
A
S
Site 112
S1080
G
S
W
G
K
G
S
S
G
G
A
K
A
S
E
Site 113
S1086
S
S
G
G
A
K
A
S
E
T
D
A
L
R
S
Site 114
T1088
G
G
A
K
A
S
E
T
D
A
L
R
S
S
A
Site 115
S1093
S
E
T
D
A
L
R
S
S
A
S
S
L
N
R
Site 116
S1094
E
T
D
A
L
R
S
S
A
S
S
L
N
R
F
Site 117
S1096
D
A
L
R
S
S
A
S
S
L
N
R
F
S
A
Site 118
S1097
A
L
R
S
S
A
S
S
L
N
R
F
S
A
L
Site 119
S1102
A
S
S
L
N
R
F
S
A
L
Q
P
P
A
P
Site 120
S1110
A
L
Q
P
P
A
P
S
G
S
T
P
S
T
P
Site 121
S1112
Q
P
P
A
P
S
G
S
T
P
S
T
P
V
E
Site 122
T1113
P
P
A
P
S
G
S
T
P
S
T
P
V
E
F
Site 123
S1115
A
P
S
G
S
T
P
S
T
P
V
E
F
D
S
Site 124
T1116
P
S
G
S
T
P
S
T
P
V
E
F
D
S
R
Site 125
S1122
S
T
P
V
E
F
D
S
R
R
T
L
T
S
R
Site 126
T1125
V
E
F
D
S
R
R
T
L
T
S
R
G
S
M
Site 127
T1127
F
D
S
R
R
T
L
T
S
R
G
S
M
G
R
Site 128
S1128
D
S
R
R
T
L
T
S
R
G
S
M
G
R
E
Site 129
S1131
R
T
L
T
S
R
G
S
M
G
R
E
K
N
D
Site 130
S1143
K
N
D
K
P
L
P
S
A
T
A
R
P
N
T
Site 131
T1145
D
K
P
L
P
S
A
T
A
R
P
N
T
F
M
Site 132
T1150
S
A
T
A
R
P
N
T
F
M
R
G
G
S
S
Site 133
S1156
N
T
F
M
R
G
G
S
S
K
D
L
L
D
N
Site 134
S1157
T
F
M
R
G
G
S
S
K
D
L
L
D
N
Q
Site 135
S1165
K
D
L
L
D
N
Q
S
Q
E
E
Q
R
R
E
Site 136
T1176
Q
R
R
E
M
L
E
T
V
K
Q
L
T
G
G
Site 137
S1190
G
V
D
V
E
R
N
S
T
E
A
E
R
N
K
Site 138
T1191
V
D
V
E
R
N
S
T
E
A
E
R
N
K
T
Site 139
T1198
T
E
A
E
R
N
K
T
R
E
S
A
K
P
E
Site 140
S1201
E
R
N
K
T
R
E
S
A
K
P
E
I
S
A
Site 141
S1218
A
H
D
K
A
A
L
S
E
E
E
L
E
R
K
Site 142
S1226
E
E
E
L
E
R
K
S
K
S
I
I
D
E
F
Site 143
S1228
E
L
E
R
K
S
K
S
I
I
D
E
F
L
H
Site 144
S1265
F
V
R
V
G
V
E
S
T
L
E
R
S
Q
I
Site 145
T1266
V
R
V
G
V
E
S
T
L
E
R
S
Q
I
T
Site 146
S1270
V
E
S
T
L
E
R
S
Q
I
T
R
D
H
M
Site 147
Y1282
D
H
M
G
Q
L
L
Y
Q
L
V
Q
S
E
K
Site 148
S1291
L
V
Q
S
E
K
L
S
K
Q
D
F
F
K
G
Site 149
S1300
Q
D
F
F
K
G
F
S
E
T
L
E
L
A
D
Site 150
S1334
M
L
K
E
G
G
I
S
M
R
E
L
T
I
E
Site 151
T1339
G
I
S
M
R
E
L
T
I
E
F
S
K
P
L
Site 152
S1368
H
L
L
C
K
Q
M
S
H
K
K
V
G
A
L
Site 153
S1382
L
W
R
E
A
D
L
S
W
K
D
F
L
P
E
Site 154
S1407
Q
K
L
D
F
I
E
S
D
S
P
C
S
S
E
Site 155
S1409
L
D
F
I
E
S
D
S
P
C
S
S
E
A
L
Site 156
S1412
I
E
S
D
S
P
C
S
S
E
A
L
S
K
K
Site 157
S1413
E
S
D
S
P
C
S
S
E
A
L
S
K
K
E
Site 158
S1417
P
C
S
S
E
A
L
S
K
K
E
L
S
A
E
Site 159
S1422
A
L
S
K
K
E
L
S
A
E
E
L
Y
K
R
Site 160
Y1427
E
L
S
A
E
E
L
Y
K
R
L
E
K
L
I
Site 161
S1458
N
L
D
E
I
Q
M
S
S
P
T
F
L
R
A
Site 162
T1486
S
S
T
F
R
V
D
T
A
V
I
K
Q
R
V
Site 163
Y1499
R
V
P
I
L
L
K
Y
L
D
S
D
T
E
K
Site 164
S1502
I
L
L
K
Y
L
D
S
D
T
E
K
E
L
Q
Site 165
T1504
L
K
Y
L
D
S
D
T
E
K
E
L
Q
A
L
Site 166
Y1536
R
M
F
F
D
C
L
Y
D
E
E
V
I
S
E
Site 167
Y1547
V
I
S
E
D
A
F
Y
K
W
E
S
S
K
D
Site 168
S1552
A
F
Y
K
W
E
S
S
K
D
P
A
E
Q
N
Site 169
S1582
L
R
E
A
E
E
E
S
E
D
N
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation