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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SYNJ1
Full Name:
Synaptojanin-1
Alias:
INPP5G; Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1; Synaptic inositol-1,4,5-trisphosphate 5-phosphatase 1; Synaptic inositol-1;4;5-trisphosphate 5-phosphatase 1; Synaptojanin 1
Type:
Vesicle protein; Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.36; Phosphatase, lipid
Mass (Da):
173103
Number AA:
1573
UniProt ID:
O43426
International Prot ID:
IPI00012441
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0004445
GO:0004439
PhosphoSite+
KinaseNET
Biological Process:
GO:0016311
GO:0048488
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S4
_
_
_
_
M
A
F
S
K
G
F
R
I
Y
H
Site 2
Y10
F
S
K
G
F
R
I
Y
H
K
L
D
P
P
P
Site 3
S19
K
L
D
P
P
P
F
S
L
I
V
E
T
R
H
Site 4
Y60
Y
S
K
V
L
D
A
Y
G
L
L
G
V
L
R
Site 5
S100
S
E
V
F
R
V
T
S
T
E
F
I
S
L
R
Site 6
S105
V
T
S
T
E
F
I
S
L
R
I
D
S
S
D
Site 7
S110
F
I
S
L
R
I
D
S
S
D
E
D
R
I
S
Site 8
S111
I
S
L
R
I
D
S
S
D
E
D
R
I
S
E
Site 9
S117
S
S
D
E
D
R
I
S
E
V
R
K
V
L
N
Site 10
Y129
V
L
N
S
G
N
F
Y
F
A
W
S
A
S
G
Site 11
S142
S
G
I
S
L
D
L
S
L
N
A
H
R
S
M
Site 12
S148
L
S
L
N
A
H
R
S
M
Q
E
Q
T
T
D
Site 13
Y171
L
H
L
H
L
K
H
Y
G
V
N
C
D
D
W
Site 14
Y193
G
V
E
I
R
T
I
Y
A
A
H
K
Q
A
K
Site 15
S208
A
C
L
I
S
R
L
S
C
E
R
A
G
T
R
Site 16
T214
L
S
C
E
R
A
G
T
R
F
N
V
R
G
T
Site 17
T221
T
R
F
N
V
R
G
T
N
D
D
G
H
V
A
Site 18
Y238
V
E
T
E
Q
V
V
Y
L
D
D
S
V
S
S
Site 19
S245
Y
L
D
D
S
V
S
S
F
I
Q
I
R
G
S
Site 20
S266
Q
P
G
L
Q
V
G
S
H
R
V
R
M
S
R
Site 21
S272
G
S
H
R
V
R
M
S
R
G
F
E
A
N
A
Site 22
T288
A
F
D
R
H
F
R
T
L
K
N
L
Y
G
K
Site 23
S312
K
E
G
E
H
M
L
S
K
A
F
Q
S
H
L
Site 24
Y335
I
Q
M
V
N
F
D
Y
H
Q
M
V
K
G
G
Site 25
S349
G
K
A
E
K
L
H
S
V
L
K
P
Q
V
Q
Site 26
Y361
Q
V
Q
K
F
L
D
Y
G
F
F
Y
F
N
G
Site 27
Y365
F
L
D
Y
G
F
F
Y
F
N
G
S
E
V
Q
Site 28
S376
S
E
V
Q
R
C
Q
S
G
T
V
R
T
N
C
Site 29
T378
V
Q
R
C
Q
S
G
T
V
R
T
N
C
L
D
Site 30
T419
A
E
K
P
Q
L
V
T
R
F
Q
E
V
F
R
Site 31
S430
E
V
F
R
S
M
W
S
V
N
G
D
S
I
S
Site 32
S437
S
V
N
G
D
S
I
S
K
I
Y
A
G
T
G
Site 33
T443
I
S
K
I
Y
A
G
T
G
A
L
E
G
K
A
Site 34
S458
K
L
K
D
G
A
R
S
V
T
R
T
I
Q
N
Site 35
T460
K
D
G
A
R
S
V
T
R
T
I
Q
N
N
F
Site 36
T462
G
A
R
S
V
T
R
T
I
Q
N
N
F
F
D
Site 37
T498
D
K
A
R
A
L
L
T
T
G
S
L
R
V
S
Site 38
T499
K
A
R
A
L
L
T
T
G
S
L
R
V
S
E
Site 39
S501
R
A
L
L
T
T
G
S
L
R
V
S
E
Q
T
Site 40
S505
T
T
G
S
L
R
V
S
E
Q
T
L
Q
S
A
Site 41
T508
S
L
R
V
S
E
Q
T
L
Q
S
A
S
S
K
Site 42
S511
V
S
E
Q
T
L
Q
S
A
S
S
K
V
L
K
Site 43
S513
E
Q
T
L
Q
S
A
S
S
K
V
L
K
S
M
Site 44
S514
Q
T
L
Q
S
A
S
S
K
V
L
K
S
M
C
Site 45
S519
A
S
S
K
V
L
K
S
M
C
E
N
F
Y
K
Site 46
Y525
K
S
M
C
E
N
F
Y
K
Y
S
K
P
K
K
Site 47
Y527
M
C
E
N
F
Y
K
Y
S
K
P
K
K
I
R
Site 48
S550
N
G
G
K
Q
F
R
S
I
A
F
K
N
Q
T
Site 49
T557
S
I
A
F
K
N
Q
T
L
T
D
W
L
L
D
Site 50
S602
L
N
A
G
N
I
V
S
A
S
T
T
N
Q
K
Site 51
S604
A
G
N
I
V
S
A
S
T
T
N
Q
K
L
W
Site 52
T606
N
I
V
S
A
S
T
T
N
Q
K
L
W
A
V
Site 53
T618
W
A
V
E
L
Q
K
T
I
S
R
D
N
K
Y
Site 54
S620
V
E
L
Q
K
T
I
S
R
D
N
K
Y
V
L
Site 55
Y625
T
I
S
R
D
N
K
Y
V
L
L
A
S
E
Q
Site 56
T680
A
I
R
M
L
F
H
T
T
S
L
C
F
V
C
Site 57
S695
S
H
F
A
A
G
Q
S
Q
V
K
E
R
N
E
Site 58
S753
I
R
Q
Q
N
W
D
S
L
I
A
G
D
Q
L
Site 59
T779
G
F
L
E
G
K
V
T
F
A
P
T
Y
K
Y
Site 60
T783
G
K
V
T
F
A
P
T
Y
K
Y
D
L
F
S
Site 61
Y784
K
V
T
F
A
P
T
Y
K
Y
D
L
F
S
D
Site 62
Y786
T
F
A
P
T
Y
K
Y
D
L
F
S
D
D
Y
Site 63
S790
T
Y
K
Y
D
L
F
S
D
D
Y
D
T
S
E
Site 64
Y793
Y
D
L
F
S
D
D
Y
D
T
S
E
K
C
R
Site 65
T795
L
F
S
D
D
Y
D
T
S
E
K
C
R
T
P
Site 66
T801
D
T
S
E
K
C
R
T
P
A
W
T
D
R
V
Site 67
S820
R
K
W
P
F
D
R
S
A
E
D
L
D
L
L
Site 68
S830
D
L
D
L
L
N
A
S
F
Q
D
E
S
K
I
Site 69
Y839
Q
D
E
S
K
I
L
Y
T
W
T
P
G
T
L
Site 70
T840
D
E
S
K
I
L
Y
T
W
T
P
G
T
L
L
Site 71
T842
S
K
I
L
Y
T
W
T
P
G
T
L
L
H
Y
Site 72
T845
L
Y
T
W
T
P
G
T
L
L
H
Y
G
R
A
Site 73
Y849
T
P
G
T
L
L
H
Y
G
R
A
E
L
K
T
Site 74
T856
Y
G
R
A
E
L
K
T
S
D
H
R
P
V
V
Site 75
S857
G
R
A
E
L
K
T
S
D
H
R
P
V
V
A
Site 76
S899
P
D
G
T
V
L
V
S
I
K
S
S
L
P
E
Site 77
T941
V
E
D
K
M
W
V
T
F
L
E
G
S
S
A
Site 78
T965
E
L
L
N
R
T
I
T
I
A
L
K
S
P
D
Site 79
S982
K
N
L
E
E
E
M
S
L
E
K
I
S
I
A
Site 80
S996
A
L
P
S
S
T
S
S
T
L
L
G
E
D
A
Site 81
T997
L
P
S
S
T
S
S
T
L
L
G
E
D
A
E
Site 82
Y1018
M
E
G
D
V
D
D
Y
S
A
E
V
E
E
L
Site 83
S1019
E
G
D
V
D
D
Y
S
A
E
V
E
E
L
L
Site 84
S1033
L
P
Q
H
L
Q
P
S
S
S
S
G
L
G
T
Site 85
S1034
P
Q
H
L
Q
P
S
S
S
S
G
L
G
T
S
Site 86
S1035
Q
H
L
Q
P
S
S
S
S
G
L
G
T
S
P
Site 87
T1040
S
S
S
S
G
L
G
T
S
P
S
S
S
P
R
Site 88
S1041
S
S
S
G
L
G
T
S
P
S
S
S
P
R
T
Site 89
S1043
S
G
L
G
T
S
P
S
S
S
P
R
T
S
P
Site 90
S1044
G
L
G
T
S
P
S
S
S
P
R
T
S
P
C
Site 91
S1045
L
G
T
S
P
S
S
S
P
R
T
S
P
C
Q
Site 92
T1048
S
P
S
S
S
P
R
T
S
P
C
Q
S
P
T
Site 93
S1049
P
S
S
S
P
R
T
S
P
C
Q
S
P
T
I
Site 94
S1053
P
R
T
S
P
C
Q
S
P
T
I
S
E
G
P
Site 95
T1055
T
S
P
C
Q
S
P
T
I
S
E
G
P
V
P
Site 96
S1057
P
C
Q
S
P
T
I
S
E
G
P
V
P
S
L
Site 97
S1063
I
S
E
G
P
V
P
S
L
P
I
R
P
S
R
Site 98
S1069
P
S
L
P
I
R
P
S
R
A
P
S
R
T
P
Site 99
S1073
I
R
P
S
R
A
P
S
R
T
P
G
P
P
S
Site 100
T1075
P
S
R
A
P
S
R
T
P
G
P
P
S
A
Q
Site 101
S1080
S
R
T
P
G
P
P
S
A
Q
S
S
P
I
D
Site 102
S1083
P
G
P
P
S
A
Q
S
S
P
I
D
A
Q
P
Site 103
S1084
G
P
P
S
A
Q
S
S
P
I
D
A
Q
P
A
Site 104
T1092
P
I
D
A
Q
P
A
T
P
L
P
Q
K
D
P
Site 105
T1118
P
R
P
V
A
P
P
T
R
P
A
P
P
Q
R
Site 106
S1130
P
Q
R
P
P
P
P
S
G
A
R
S
P
A
P
Site 107
S1134
P
P
P
S
G
A
R
S
P
A
P
T
R
K
E
Site 108
T1138
G
A
R
S
P
A
P
T
R
K
E
F
G
G
I
Site 109
S1150
G
G
I
G
A
P
P
S
P
G
V
A
R
R
E
Site 110
S1163
R
E
M
E
A
P
K
S
P
G
T
T
R
K
D
Site 111
T1166
E
A
P
K
S
P
G
T
T
R
K
D
N
I
G
Site 112
S1175
R
K
D
N
I
G
R
S
Q
P
S
P
Q
A
G
Site 113
S1178
N
I
G
R
S
Q
P
S
P
Q
A
G
L
A
G
Site 114
Y1191
A
G
P
G
P
A
G
Y
S
T
A
R
P
T
I
Site 115
T1193
P
G
P
A
G
Y
S
T
A
R
P
T
I
P
P
Site 116
T1197
G
Y
S
T
A
R
P
T
I
P
P
R
A
G
V
Site 117
S1206
P
P
R
A
G
V
I
S
A
P
Q
S
H
A
R
Site 118
S1210
G
V
I
S
A
P
Q
S
H
A
R
A
S
A
G
Site 119
S1215
P
Q
S
H
A
R
A
S
A
G
R
L
T
P
E
Site 120
T1220
R
A
S
A
G
R
L
T
P
E
S
Q
S
K
T
Site 121
S1223
A
G
R
L
T
P
E
S
Q
S
K
T
S
E
T
Site 122
S1225
R
L
T
P
E
S
Q
S
K
T
S
E
T
S
K
Site 123
T1227
T
P
E
S
Q
S
K
T
S
E
T
S
K
G
S
Site 124
S1228
P
E
S
Q
S
K
T
S
E
T
S
K
G
S
T
Site 125
T1230
S
Q
S
K
T
S
E
T
S
K
G
S
T
F
L
Site 126
T1235
S
E
T
S
K
G
S
T
F
L
P
E
P
L
K
Site 127
S1251
Q
A
A
F
P
P
Q
S
S
L
P
P
P
A
Q
Site 128
S1252
A
A
F
P
P
Q
S
S
L
P
P
P
A
Q
R
Site 129
S1274
V
A
A
P
M
P
Q
S
G
P
Q
P
N
L
E
Site 130
T1282
G
P
Q
P
N
L
E
T
P
P
Q
P
P
P
R
Site 131
S1290
P
P
Q
P
P
P
R
S
R
S
S
H
S
L
P
Site 132
S1292
Q
P
P
P
R
S
R
S
S
H
S
L
P
S
E
Site 133
S1293
P
P
P
R
S
R
S
S
H
S
L
P
S
E
A
Site 134
S1295
P
R
S
R
S
S
H
S
L
P
S
E
A
S
S
Site 135
S1298
R
S
S
H
S
L
P
S
E
A
S
S
Q
P
Q
Site 136
S1301
H
S
L
P
S
E
A
S
S
Q
P
Q
V
K
T
Site 137
S1302
S
L
P
S
E
A
S
S
Q
P
Q
V
K
T
N
Site 138
T1308
S
S
Q
P
Q
V
K
T
N
G
I
S
D
G
K
Site 139
S1318
I
S
D
G
K
R
E
S
P
L
K
I
D
P
F
Site 140
S1341
A
V
S
K
A
Q
L
S
V
Q
T
S
P
V
P
Site 141
T1344
K
A
Q
L
S
V
Q
T
S
P
V
P
T
P
D
Site 142
S1345
A
Q
L
S
V
Q
T
S
P
V
P
T
P
D
P
Site 143
T1349
V
Q
T
S
P
V
P
T
P
D
P
K
R
L
I
Site 144
S1360
K
R
L
I
Q
L
P
S
A
T
Q
S
N
V
L
Site 145
S1364
Q
L
P
S
A
T
Q
S
N
V
L
S
S
V
S
Site 146
T1375
S
S
V
S
C
M
P
T
M
P
P
I
P
A
R
Site 147
S1383
M
P
P
I
P
A
R
S
Q
S
Q
E
N
M
R
Site 148
S1385
P
I
P
A
R
S
Q
S
Q
E
N
M
R
S
S
Site 149
S1391
Q
S
Q
E
N
M
R
S
S
P
N
P
F
I
T
Site 150
S1392
S
Q
E
N
M
R
S
S
P
N
P
F
I
T
G
Site 151
S1407
L
T
R
T
N
P
F
S
D
R
T
A
A
P
G
Site 152
T1410
T
N
P
F
S
D
R
T
A
A
P
G
N
P
F
Site 153
S1421
G
N
P
F
R
A
K
S
E
E
S
E
A
T
S
Site 154
S1424
F
R
A
K
S
E
E
S
E
A
T
S
W
F
S
Site 155
T1427
K
S
E
E
S
E
A
T
S
W
F
S
K
E
E
Site 156
S1428
S
E
E
S
E
A
T
S
W
F
S
K
E
E
P
Site 157
T1437
F
S
K
E
E
P
V
T
I
S
P
F
P
S
L
Site 158
S1439
K
E
E
P
V
T
I
S
P
F
P
S
L
Q
P
Site 159
S1443
V
T
I
S
P
F
P
S
L
Q
P
L
G
H
N
Site 160
S1452
Q
P
L
G
H
N
K
S
R
A
S
S
S
L
D
Site 161
S1455
G
H
N
K
S
R
A
S
S
S
L
D
G
F
K
Site 162
S1456
H
N
K
S
R
A
S
S
S
L
D
G
F
K
D
Site 163
S1457
N
K
S
R
A
S
S
S
L
D
G
F
K
D
S
Site 164
S1464
S
L
D
G
F
K
D
S
F
D
L
Q
G
Q
S
Site 165
S1471
S
F
D
L
Q
G
Q
S
T
L
K
I
S
N
P
Site 166
T1472
F
D
L
Q
G
Q
S
T
L
K
I
S
N
P
K
Site 167
T1483
S
N
P
K
G
W
V
T
F
E
E
E
E
D
F
Site 168
S1496
D
F
G
V
K
G
K
S
K
S
A
C
S
D
L
Site 169
S1498
G
V
K
G
K
S
K
S
A
C
S
D
L
L
G
Site 170
S1509
D
L
L
G
N
Q
P
S
S
F
S
G
S
N
L
Site 171
S1510
L
L
G
N
Q
P
S
S
F
S
G
S
N
L
T
Site 172
S1512
G
N
Q
P
S
S
F
S
G
S
N
L
T
L
N
Site 173
S1514
Q
P
S
S
F
S
G
S
N
L
T
L
N
D
D
Site 174
T1517
S
F
S
G
S
N
L
T
L
N
D
D
W
N
K
Site 175
S1529
W
N
K
G
T
N
V
S
F
C
V
L
P
S
R
Site 176
S1535
V
S
F
C
V
L
P
S
R
R
P
P
P
P
P
Site 177
S1551
P
L
L
P
P
G
T
S
P
P
V
D
P
F
T
Site 178
T1558
S
P
P
V
D
P
F
T
T
L
A
S
K
A
S
Site 179
T1559
P
P
V
D
P
F
T
T
L
A
S
K
A
S
P
Site 180
S1562
D
P
F
T
T
L
A
S
K
A
S
P
T
L
D
Site 181
S1565
T
T
L
A
S
K
A
S
P
T
L
D
F
T
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation