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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SIAH2
Full Name:
E3 ubiquitin-protein ligase SIAH2
Alias:
EC 6.3.2.-; HSiah2; Seven in absentia homologue 2; Siah-2
Type:
Cytoplasm, Nucleus protein; Ubiquitin conjugating protein
Mass (Da):
34615
Number AA:
324
UniProt ID:
O43255
International Prot ID:
IPI00305283
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003714
GO:0004842
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0007049
GO:0007275
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
S
R
P
S
S
T
G
P
S
A
N
Site 2
S6
_
_
M
S
R
P
S
S
T
G
P
S
A
N
K
Site 3
T7
_
M
S
R
P
S
S
T
G
P
S
A
N
K
P
Site 4
S10
R
P
S
S
T
G
P
S
A
N
K
P
C
S
K
Site 5
S16
P
S
A
N
K
P
C
S
K
Q
P
P
P
Q
P
Site 6
T26
P
P
P
Q
P
Q
H
T
P
S
P
A
A
P
P
Site 7
S28
P
Q
P
Q
H
T
P
S
P
A
A
P
P
A
A
Site 8
S68
G
G
G
A
G
P
V
S
P
Q
H
H
E
L
T
Site 9
T113
Q
K
L
S
C
C
P
T
C
R
G
A
L
T
P
Site 10
T119
P
T
C
R
G
A
L
T
P
S
I
R
N
L
A
Site 11
S121
C
R
G
A
L
T
P
S
I
R
N
L
A
M
E
Site 12
Y140
A
V
L
F
P
C
K
Y
A
T
T
G
C
S
L
Site 13
S146
K
Y
A
T
T
G
C
S
L
T
L
H
H
T
E
Site 14
T148
A
T
T
G
C
S
L
T
L
H
H
T
E
K
P
Site 15
T152
C
S
L
T
L
H
H
T
E
K
P
E
H
E
D
Site 16
Y163
E
H
E
D
I
C
E
Y
R
P
Y
S
C
P
C
Site 17
Y166
D
I
C
E
Y
R
P
Y
S
C
P
C
P
G
A
Site 18
S167
I
C
E
Y
R
P
Y
S
C
P
C
P
G
A
S
Site 19
S180
A
S
C
K
W
Q
G
S
L
E
A
V
M
S
H
Site 20
S186
G
S
L
E
A
V
M
S
H
L
M
H
A
H
K
Site 21
S194
H
L
M
H
A
H
K
S
I
T
T
L
Q
G
E
Site 22
Y239
V
L
E
K
Q
E
K
Y
E
G
H
Q
Q
F
F
Site 23
T254
A
I
V
L
L
I
G
T
R
K
Q
A
E
N
F
Site 24
Y263
K
Q
A
E
N
F
A
Y
R
L
E
L
N
G
N
Site 25
T275
N
G
N
R
R
R
L
T
W
E
A
T
P
R
S
Site 26
T279
R
R
L
T
W
E
A
T
P
R
S
I
H
D
G
Site 27
S282
T
W
E
A
T
P
R
S
I
H
D
G
V
A
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation