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Updated November 2019
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Protein Info
Short Name:
SIPA1L1
Full Name:
Signal-induced proliferation-associated 1-like protein 1
Alias:
E6-targeted protein 1; E6TP1; High-risk human papilloma viruses E6 oncoproteins targeted protein 1; High-risk human papilloma viruses E6 oncoproteins targeted protein 1;E6-targeted protein 1; KIAA0440; SI1L1; Signal-induced proliferation-associated 1 like 1; Signal-induced proliferation-associated 1 like protein 1; SIL1
Type:
GTPase activating protein, misc.
Mass (Da):
200029
Number AA:
1804
UniProt ID:
O43166
International Prot ID:
IPI00413362
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005096
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0051056
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
T
S
L
K
R
S
Q
T
E
R
P
L
A
Site 2
T9
T
S
L
K
R
S
Q
T
E
R
P
L
A
T
D
Site 3
T15
Q
T
E
R
P
L
A
T
D
R
A
S
V
V
G
Site 4
S19
P
L
A
T
D
R
A
S
V
V
G
T
D
G
T
Site 5
T26
S
V
V
G
T
D
G
T
P
K
V
H
T
D
D
Site 6
T31
D
G
T
P
K
V
H
T
D
D
F
Y
M
R
R
Site 7
Y35
K
V
H
T
D
D
F
Y
M
R
R
F
R
S
Q
Site 8
S41
F
Y
M
R
R
F
R
S
Q
N
G
S
L
G
S
Site 9
S45
R
F
R
S
Q
N
G
S
L
G
S
S
V
M
A
Site 10
S48
S
Q
N
G
S
L
G
S
S
V
M
A
P
V
G
Site 11
S49
Q
N
G
S
L
G
S
S
V
M
A
P
V
G
P
Site 12
S59
A
P
V
G
P
P
R
S
E
G
S
H
H
I
T
Site 13
S62
G
P
P
R
S
E
G
S
H
H
I
T
S
T
P
Site 14
T66
S
E
G
S
H
H
I
T
S
T
P
G
V
P
K
Site 15
S67
E
G
S
H
H
I
T
S
T
P
G
V
P
K
M
Site 16
T68
G
S
H
H
I
T
S
T
P
G
V
P
K
M
G
Site 17
S93
R
K
E
N
I
K
E
S
S
R
S
S
Q
E
I
Site 18
S96
N
I
K
E
S
S
R
S
S
Q
E
I
E
T
S
Site 19
S97
I
K
E
S
S
R
S
S
Q
E
I
E
T
S
S
Site 20
S103
S
S
Q
E
I
E
T
S
S
C
L
D
S
L
S
Site 21
S104
S
Q
E
I
E
T
S
S
C
L
D
S
L
S
S
Site 22
S108
E
T
S
S
C
L
D
S
L
S
S
K
S
S
P
Site 23
S110
S
S
C
L
D
S
L
S
S
K
S
S
P
V
S
Site 24
S111
S
C
L
D
S
L
S
S
K
S
S
P
V
S
Q
Site 25
S113
L
D
S
L
S
S
K
S
S
P
V
S
Q
G
S
Site 26
S114
D
S
L
S
S
K
S
S
P
V
S
Q
G
S
S
Site 27
S117
S
S
K
S
S
P
V
S
Q
G
S
S
V
S
L
Site 28
S120
S
S
P
V
S
Q
G
S
S
V
S
L
N
S
N
Site 29
S121
S
P
V
S
Q
G
S
S
V
S
L
N
S
N
D
Site 30
S123
V
S
Q
G
S
S
V
S
L
N
S
N
D
S
A
Site 31
S126
G
S
S
V
S
L
N
S
N
D
S
A
M
L
K
Site 32
S129
V
S
L
N
S
N
D
S
A
M
L
K
S
I
Q
Site 33
S134
N
D
S
A
M
L
K
S
I
Q
N
T
L
K
N
Site 34
T138
M
L
K
S
I
Q
N
T
L
K
N
K
T
R
P
Site 35
S146
L
K
N
K
T
R
P
S
E
N
M
D
S
R
F
Site 36
S151
R
P
S
E
N
M
D
S
R
F
L
M
P
E
A
Site 37
Y159
R
F
L
M
P
E
A
Y
P
S
S
P
R
K
A
Site 38
S161
L
M
P
E
A
Y
P
S
S
P
R
K
A
L
R
Site 39
S162
M
P
E
A
Y
P
S
S
P
R
K
A
L
R
R
Site 40
S174
L
R
R
I
R
Q
R
S
N
S
D
I
T
I
S
Site 41
S176
R
I
R
Q
R
S
N
S
D
I
T
I
S
E
L
Site 42
S181
S
N
S
D
I
T
I
S
E
L
D
V
D
S
F
Site 43
S187
I
S
E
L
D
V
D
S
F
D
E
C
I
S
P
Site 44
S193
D
S
F
D
E
C
I
S
P
T
Y
K
T
G
P
Site 45
T195
F
D
E
C
I
S
P
T
Y
K
T
G
P
S
L
Site 46
Y196
D
E
C
I
S
P
T
Y
K
T
G
P
S
L
H
Site 47
T198
C
I
S
P
T
Y
K
T
G
P
S
L
H
R
E
Site 48
S201
P
T
Y
K
T
G
P
S
L
H
R
E
Y
G
S
Site 49
Y206
G
P
S
L
H
R
E
Y
G
S
T
S
S
I
D
Site 50
S208
S
L
H
R
E
Y
G
S
T
S
S
I
D
K
Q
Site 51
T209
L
H
R
E
Y
G
S
T
S
S
I
D
K
Q
G
Site 52
S210
H
R
E
Y
G
S
T
S
S
I
D
K
Q
G
T
Site 53
S211
R
E
Y
G
S
T
S
S
I
D
K
Q
G
T
S
Site 54
T217
S
S
I
D
K
Q
G
T
S
G
E
S
F
F
D
Site 55
S218
S
I
D
K
Q
G
T
S
G
E
S
F
F
D
L
Site 56
S221
K
Q
G
T
S
G
E
S
F
F
D
L
L
K
G
Site 57
S234
K
G
Y
K
D
D
K
S
D
R
G
P
T
P
T
Site 58
T239
D
K
S
D
R
G
P
T
P
T
K
L
S
D
F
Site 59
T241
S
D
R
G
P
T
P
T
K
L
S
D
F
L
I
Site 60
S244
G
P
T
P
T
K
L
S
D
F
L
I
T
G
G
Site 61
S255
I
T
G
G
G
K
G
S
G
F
S
L
D
V
I
Site 62
S258
G
G
K
G
S
G
F
S
L
D
V
I
D
G
P
Site 63
S267
D
V
I
D
G
P
I
S
Q
R
E
N
L
R
L
Site 64
S286
E
K
P
L
K
R
R
S
K
S
E
T
G
D
S
Site 65
S288
P
L
K
R
R
S
K
S
E
T
G
D
S
S
I
Site 66
T290
K
R
R
S
K
S
E
T
G
D
S
S
I
F
R
Site 67
S293
S
K
S
E
T
G
D
S
S
I
F
R
K
L
R
Site 68
S294
K
S
E
T
G
D
S
S
I
F
R
K
L
R
N
Site 69
S310
K
G
E
E
L
G
K
S
S
D
L
E
D
N
R
Site 70
S311
G
E
E
L
G
K
S
S
D
L
E
D
N
R
S
Site 71
S318
S
D
L
E
D
N
R
S
E
D
S
V
R
P
W
Site 72
S321
E
D
N
R
S
E
D
S
V
R
P
W
T
C
P
Site 73
T359
N
V
I
K
R
R
N
T
T
T
G
A
S
A
A
Site 74
T360
V
I
K
R
R
N
T
T
T
G
A
S
A
A
A
Site 75
T361
I
K
R
R
N
T
T
T
G
A
S
A
A
A
V
Site 76
S373
A
A
V
A
S
L
V
S
G
P
L
S
H
S
A
Site 77
S377
S
L
V
S
G
P
L
S
H
S
A
S
F
S
S
Site 78
S379
V
S
G
P
L
S
H
S
A
S
F
S
S
P
M
Site 79
S381
G
P
L
S
H
S
A
S
F
S
S
P
M
G
S
Site 80
S383
L
S
H
S
A
S
F
S
S
P
M
G
S
T
E
Site 81
S384
S
H
S
A
S
F
S
S
P
M
G
S
T
E
D
Site 82
S388
S
F
S
S
P
M
G
S
T
E
D
L
N
S
K
Site 83
T389
F
S
S
P
M
G
S
T
E
D
L
N
S
K
G
Site 84
S394
G
S
T
E
D
L
N
S
K
G
S
L
S
M
D
Site 85
S397
E
D
L
N
S
K
G
S
L
S
M
D
Q
G
D
Site 86
S399
L
N
S
K
G
S
L
S
M
D
Q
G
D
D
K
Site 87
S413
K
S
N
E
L
V
M
S
C
P
Y
F
R
N
E
Site 88
Y416
E
L
V
M
S
C
P
Y
F
R
N
E
I
G
G
Site 89
S430
G
E
G
E
R
K
I
S
L
S
K
S
N
S
G
Site 90
S432
G
E
R
K
I
S
L
S
K
S
N
S
G
S
F
Site 91
S434
R
K
I
S
L
S
K
S
N
S
G
S
F
S
G
Site 92
S436
I
S
L
S
K
S
N
S
G
S
F
S
G
C
E
Site 93
S438
L
S
K
S
N
S
G
S
F
S
G
C
E
S
A
Site 94
S440
K
S
N
S
G
S
F
S
G
C
E
S
A
S
F
Site 95
S444
G
S
F
S
G
C
E
S
A
S
F
E
S
T
L
Site 96
S446
F
S
G
C
E
S
A
S
F
E
S
T
L
S
S
Site 97
S449
C
E
S
A
S
F
E
S
T
L
S
S
H
C
T
Site 98
T450
E
S
A
S
F
E
S
T
L
S
S
H
C
T
N
Site 99
S452
A
S
F
E
S
T
L
S
S
H
C
T
N
A
G
Site 100
S453
S
F
E
S
T
L
S
S
H
C
T
N
A
G
V
Site 101
Y490
E
H
V
D
L
G
A
Y
Y
Y
R
K
F
F
Y
Site 102
Y491
H
V
D
L
G
A
Y
Y
Y
R
K
F
F
Y
Q
Site 103
Y492
V
D
L
G
A
Y
Y
Y
R
K
F
F
Y
Q
K
Site 104
Y504
Y
Q
K
E
H
W
N
Y
F
G
A
D
E
N
L
Site 105
S517
N
L
G
P
V
A
V
S
I
R
R
E
K
P
D
Site 106
S531
D
E
M
K
E
N
G
S
P
Y
N
Y
R
I
I
Site 107
Y535
E
N
G
S
P
Y
N
Y
R
I
I
F
R
T
S
Site 108
T541
N
Y
R
I
I
F
R
T
S
E
L
M
T
L
R
Site 109
S542
Y
R
I
I
F
R
T
S
E
L
M
T
L
R
G
Site 110
T546
F
R
T
S
E
L
M
T
L
R
G
S
V
L
E
Site 111
T559
L
E
D
A
I
P
S
T
A
K
H
S
T
A
R
Site 112
T564
P
S
T
A
K
H
S
T
A
R
G
L
P
L
K
Site 113
Y609
L
D
E
Q
G
L
N
Y
Q
Q
K
V
G
I
M
Site 114
Y617
Q
Q
K
V
G
I
M
Y
C
K
A
G
Q
S
T
Site 115
Y629
Q
S
T
E
E
E
M
Y
N
N
E
S
A
G
P
Site 116
Y657
R
L
K
G
F
E
K
Y
R
A
Q
L
D
T
K
Site 117
T663
K
Y
R
A
Q
L
D
T
K
T
D
S
T
G
T
Site 118
T665
R
A
Q
L
D
T
K
T
D
S
T
G
T
H
S
Site 119
S667
Q
L
D
T
K
T
D
S
T
G
T
H
S
L
Y
Site 120
T668
L
D
T
K
T
D
S
T
G
T
H
S
L
Y
T
Site 121
S672
T
D
S
T
G
T
H
S
L
Y
T
T
Y
K
D
Site 122
Y674
S
T
G
T
H
S
L
Y
T
T
Y
K
D
Y
E
Site 123
T676
G
T
H
S
L
Y
T
T
Y
K
D
Y
E
I
M
Site 124
Y680
L
Y
T
T
Y
K
D
Y
E
I
M
F
H
V
S
Site 125
T693
V
S
T
M
L
P
Y
T
P
N
N
K
Q
Q
L
Site 126
S724
E
P
G
A
Q
P
F
S
P
K
N
I
R
S
H
Site 127
S752
C
S
D
S
V
C
Y
S
V
A
V
T
R
S
R
Site 128
T756
V
C
Y
S
V
A
V
T
R
S
R
D
V
P
S
Site 129
S763
T
R
S
R
D
V
P
S
F
G
P
P
I
P
K
Site 130
T773
P
P
I
P
K
G
V
T
F
P
K
S
N
V
F
Site 131
S777
K
G
V
T
F
P
K
S
N
V
F
R
D
F
L
Site 132
S798
A
E
N
A
A
H
K
S
E
K
F
R
A
M
A
Site 133
Y812
A
T
R
T
R
Q
E
Y
L
K
D
L
A
E
K
Site 134
T822
D
L
A
E
K
N
V
T
N
T
P
I
D
P
S
Site 135
T824
A
E
K
N
V
T
N
T
P
I
D
P
S
G
K
Site 136
S829
T
N
T
P
I
D
P
S
G
K
F
P
F
I
S
Site 137
S836
S
G
K
F
P
F
I
S
L
A
S
K
K
K
E
Site 138
S845
A
S
K
K
K
E
K
S
K
P
Y
P
G
A
E
Site 139
Y848
K
K
E
K
S
K
P
Y
P
G
A
E
L
S
S
Site 140
Y868
W
A
V
R
A
E
D
Y
N
K
A
M
E
L
D
Site 141
S894
L
I
E
Q
E
T
K
S
V
V
F
N
C
S
C
Site 142
S909
R
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L
H
R
T
Site 294
T1583
S
R
R
A
L
H
R
T
L
S
D
E
S
I
Y
Site 295
S1585
R
A
L
H
R
T
L
S
D
E
S
I
Y
N
S
Site 296
S1588
H
R
T
L
S
D
E
S
I
Y
N
S
Q
R
E
Site 297
Y1590
T
L
S
D
E
S
I
Y
N
S
Q
R
E
H
F
Site 298
S1592
S
D
E
S
I
Y
N
S
Q
R
E
H
F
F
T
Site 299
T1599
S
Q
R
E
H
F
F
T
S
R
A
S
L
L
D
Site 300
S1600
Q
R
E
H
F
F
T
S
R
A
S
L
L
D
Q
Site 301
S1603
H
F
F
T
S
R
A
S
L
L
D
Q
A
L
P
Site 302
S1617
P
N
D
V
L
F
S
S
T
Y
P
S
L
P
K
Site 303
T1618
N
D
V
L
F
S
S
T
Y
P
S
L
P
K
S
Site 304
Y1619
D
V
L
F
S
S
T
Y
P
S
L
P
K
S
L
Site 305
S1625
T
Y
P
S
L
P
K
S
L
P
L
R
R
P
S
Site 306
S1632
S
L
P
L
R
R
P
S
Y
T
L
G
M
K
S
Site 307
Y1633
L
P
L
R
R
P
S
Y
T
L
G
M
K
S
L
Site 308
T1634
P
L
R
R
P
S
Y
T
L
G
M
K
S
L
H
Site 309
S1639
S
Y
T
L
G
M
K
S
L
H
G
E
F
S
A
Site 310
S1645
K
S
L
H
G
E
F
S
A
S
D
S
S
L
T
Site 311
S1647
L
H
G
E
F
S
A
S
D
S
S
L
T
D
I
Site 312
S1649
G
E
F
S
A
S
D
S
S
L
T
D
I
Q
E
Site 313
S1650
E
F
S
A
S
D
S
S
L
T
D
I
Q
E
T
Site 314
T1673
G
L
M
P
L
P
D
T
A
A
D
L
D
W
S
Site 315
S1695
A
Y
E
V
Q
R
A
S
F
F
A
A
S
D
E
Site 316
S1700
R
A
S
F
F
A
A
S
D
E
N
H
R
P
L
Site 317
S1708
D
E
N
H
R
P
L
S
A
A
S
N
S
D
Q
Site 318
S1711
H
R
P
L
S
A
A
S
N
S
D
Q
L
E
D
Site 319
S1713
P
L
S
A
A
S
N
S
D
Q
L
E
D
Q
A
Site 320
S1728
L
A
Q
M
K
P
Y
S
S
S
K
D
S
S
P
Site 321
S1729
A
Q
M
K
P
Y
S
S
S
K
D
S
S
P
T
Site 322
S1730
Q
M
K
P
Y
S
S
S
K
D
S
S
P
T
L
Site 323
S1733
P
Y
S
S
S
K
D
S
S
P
T
L
A
S
K
Site 324
S1734
Y
S
S
S
K
D
S
S
P
T
L
A
S
K
V
Site 325
T1736
S
S
K
D
S
S
P
T
L
A
S
K
V
D
Q
Site 326
S1739
D
S
S
P
T
L
A
S
K
V
D
Q
L
E
G
Site 327
S1783
N
L
R
L
Q
E
E
S
Q
N
A
S
D
K
L
Site 328
S1787
Q
E
E
S
Q
N
A
S
D
K
L
K
K
F
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation