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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CFLAR
Full Name:
CASP8 and FADD-like apoptosis regulator
Alias:
CASH; CASP8AP1; Caspase homologue; Caspase-eight-related; Caspase-like apoptosis regulatory; Caspase-related inducer of apoptosis; Casper; Cellular FLICE-like inhibitory; C-FLIP; C-FLIPL; C-FLIPR; CLARP; FADD-like anti-apoptotic molecule; FADD-like antiapoptotic molecule 1; FLAME; FLAME-1; FLIP; I-FLICE; Inhibitor of FLICE; MACH-related inducer of toxicity; MRIT; Usurpin; Usurpin beta
Type:
Apoptosis protein
Mass (Da):
55344
Number AA:
480
UniProt ID:
O15519
International Prot ID:
IPI00007287
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0004197
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006916
GO:0006915
GO:0008624
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T15
Q
V
E
E
A
L
D
T
D
E
K
E
M
L
L
Site 2
S51
L
R
E
R
G
K
L
S
V
G
D
L
A
E
L
Site 3
Y60
G
D
L
A
E
L
L
Y
R
V
R
R
F
D
L
Site 4
S91
L
R
N
P
H
L
V
S
D
Y
R
V
L
M
A
Site 5
S107
I
G
E
D
L
D
K
S
D
V
S
S
L
I
F
Site 6
S126
Y
M
G
R
G
K
I
S
K
E
K
S
F
L
D
Site 7
S130
G
K
I
S
K
E
K
S
F
L
D
L
V
V
E
Site 8
T166
I
H
R
I
D
L
K
T
K
I
Q
K
Y
K
Q
Site 9
Y171
L
K
T
K
I
Q
K
Y
K
Q
S
V
Q
G
A
Site 10
S174
K
I
Q
K
Y
K
Q
S
V
Q
G
A
G
T
S
Site 11
S181
S
V
Q
G
A
G
T
S
Y
R
N
V
L
Q
A
Site 12
Y182
V
Q
G
A
G
T
S
Y
R
N
V
L
Q
A
A
Site 13
S193
L
Q
A
A
I
Q
K
S
L
K
D
P
S
N
N
Site 14
S198
Q
K
S
L
K
D
P
S
N
N
F
R
L
H
N
Site 15
S208
F
R
L
H
N
G
R
S
K
E
Q
R
L
K
E
Site 16
S227
Q
Q
E
P
V
K
K
S
I
Q
E
S
E
A
F
Site 17
S231
V
K
K
S
I
Q
E
S
E
A
F
L
P
Q
S
Site 18
S238
S
E
A
F
L
P
Q
S
I
P
E
E
R
Y
K
Site 19
S248
E
E
R
Y
K
M
K
S
K
P
L
G
I
C
L
Site 20
T270
E
T
E
L
L
R
D
T
F
T
S
L
G
Y
E
Site 21
T272
E
L
L
R
D
T
F
T
S
L
G
Y
E
V
Q
Site 22
S273
L
L
R
D
T
F
T
S
L
G
Y
E
V
Q
K
Site 23
Y305
C
M
P
E
H
R
D
Y
D
S
F
V
C
V
L
Site 24
S307
P
E
H
R
D
Y
D
S
F
V
C
V
L
V
S
Site 25
S314
S
F
V
C
V
L
V
S
R
G
G
S
Q
S
V
Site 26
S320
V
S
R
G
G
S
Q
S
V
Y
G
V
D
Q
T
Site 27
Y322
R
G
G
S
Q
S
V
Y
G
V
D
Q
T
H
S
Site 28
T327
S
V
Y
G
V
D
Q
T
H
S
G
L
P
L
H
Site 29
S329
Y
G
V
D
Q
T
H
S
G
L
P
L
H
H
I
Site 30
S344
R
R
M
F
M
G
D
S
C
P
Y
L
A
G
K
Site 31
Y347
F
M
G
D
S
C
P
Y
L
A
G
K
P
K
M
Site 32
S370
S
E
G
Q
L
E
D
S
S
L
L
E
V
D
G
Site 33
S371
E
G
Q
L
E
D
S
S
L
L
E
V
D
G
P
Site 34
T394
A
Q
K
R
G
L
C
T
V
H
R
E
A
D
F
Site 35
S411
S
L
C
T
A
D
M
S
L
L
E
Q
S
H
S
Site 36
S416
D
M
S
L
L
E
Q
S
H
S
S
P
S
L
Y
Site 37
S418
S
L
L
E
Q
S
H
S
S
P
S
L
Y
L
Q
Site 38
S419
L
L
E
Q
S
H
S
S
P
S
L
Y
L
Q
C
Site 39
S421
E
Q
S
H
S
S
P
S
L
Y
L
Q
C
L
S
Site 40
Y423
S
H
S
S
P
S
L
Y
L
Q
C
L
S
Q
K
Site 41
S428
S
L
Y
L
Q
C
L
S
Q
K
L
R
Q
E
R
Site 42
Y449
L
H
I
E
L
N
G
Y
M
Y
D
W
N
S
R
Site 43
Y451
I
E
L
N
G
Y
M
Y
D
W
N
S
R
V
S
Site 44
Y463
R
V
S
A
K
E
K
Y
Y
V
W
L
Q
H
T
Site 45
Y464
V
S
A
K
E
K
Y
Y
V
W
L
Q
H
T
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation