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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HDAC3
Full Name:
Histone deacetylase 3
Alias:
HD3; RPD3; RPD3-2; SMAP45
Type:
Apoptosis; Transcription, coactivator/corepressor; Deacetylase; Nuclear receptor co-regulator; EC 3.5.1.98; Cell cycle regulation
Mass (Da):
48848
Number AA:
428
UniProt ID:
O15379
International Prot ID:
IPI00006187
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0000118
GO:0005876
Uniprot
OncoNet
Molecular Function:
GO:0004407
GO:0042826
GO:0003714
PhosphoSite+
KinaseNET
Biological Process:
GO:0006916
GO:0016575
GO:0046329
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y9
A
K
T
V
A
Y
F
Y
D
P
D
V
G
N
F
Site 2
Y18
P
D
V
G
N
F
H
Y
G
A
G
H
P
M
K
Site 3
T32
K
P
H
R
L
A
L
T
H
S
L
V
L
H
Y
Site 4
Y51
K
M
I
V
F
K
P
Y
Q
A
S
Q
H
D
M
Site 5
Y66
C
R
F
H
S
E
D
Y
I
D
F
L
Q
R
V
Site 6
S74
I
D
F
L
Q
R
V
S
P
T
N
M
Q
G
F
Site 7
Y107
L
F
E
F
C
S
R
Y
T
G
A
S
L
Q
G
Site 8
T108
F
E
F
C
S
R
Y
T
G
A
S
L
Q
G
A
Site 9
S111
C
S
R
Y
T
G
A
S
L
Q
G
A
T
Q
L
Site 10
Y166
K
Y
H
P
R
V
L
Y
I
D
I
D
I
H
H
Site 11
Y182
D
G
V
Q
E
A
F
Y
L
T
D
R
V
M
T
Site 12
T189
Y
L
T
D
R
V
M
T
V
S
F
H
K
Y
G
Site 13
Y195
M
T
V
S
F
H
K
Y
G
N
Y
F
F
P
G
Site 14
Y198
S
F
H
K
Y
G
N
Y
F
F
P
G
T
G
D
Site 15
Y207
F
P
G
T
G
D
M
Y
E
V
G
A
E
S
G
Site 16
Y216
V
G
A
E
S
G
R
Y
Y
C
L
N
V
P
L
Site 17
Y217
G
A
E
S
G
R
Y
Y
C
L
N
V
P
L
R
Site 18
S231
R
D
G
I
D
D
Q
S
Y
K
H
L
F
Q
P
Site 19
Y232
D
G
I
D
D
Q
S
Y
K
H
L
F
Q
P
V
Site 20
Y282
G
H
G
E
C
V
E
Y
V
K
S
F
N
I
P
Site 21
T308
R
N
V
A
R
C
W
T
Y
E
T
S
L
L
V
Site 22
S320
L
L
V
E
E
A
I
S
E
E
L
P
Y
S
E
Site 23
Y325
A
I
S
E
E
L
P
Y
S
E
Y
F
E
Y
F
Site 24
S326
I
S
E
E
L
P
Y
S
E
Y
F
E
Y
F
A
Site 25
Y328
E
E
L
P
Y
S
E
Y
F
E
Y
F
A
P
D
Site 26
Y331
P
Y
S
E
Y
F
E
Y
F
A
P
D
F
T
L
Site 27
T337
E
Y
F
A
P
D
F
T
L
H
P
D
V
S
T
Site 28
S343
F
T
L
H
P
D
V
S
T
R
I
E
N
Q
N
Site 29
Y354
E
N
Q
N
S
R
Q
Y
L
D
Q
I
R
Q
T
Site 30
T361
Y
L
D
Q
I
R
Q
T
I
F
E
N
L
K
M
Site 31
S374
K
M
L
N
H
A
P
S
V
Q
I
H
D
V
P
Site 32
T386
D
V
P
A
D
L
L
T
Y
D
R
T
D
E
A
Site 33
Y387
V
P
A
D
L
L
T
Y
D
R
T
D
E
A
D
Site 34
T390
D
L
L
T
Y
D
R
T
D
E
A
D
A
E
E
Site 35
Y404
E
R
G
P
E
E
N
Y
S
R
P
E
A
P
N
Site 36
S405
R
G
P
E
E
N
Y
S
R
P
E
A
P
N
E
Site 37
Y414
P
E
A
P
N
E
F
Y
D
G
D
H
D
N
D
Site 38
S424
D
H
D
N
D
K
E
S
D
V
E
I
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation