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Updated November 2019
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Protein Info
Short Name:
SEC16A
Full Name:
Protein transport protein Sec16A
Alias:
INP5E; KIAA0310; p250; SC16A; SEC16 A
Type:
Phosphatase (non-protein); EC 3.1.3.36
Mass (Da):
233517
Number AA:
2179
UniProt ID:
O15027
International Prot ID:
IPI00641384
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005783
GO:0019898
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0015031
GO:0016192
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
P
G
L
D
R
P
L
S
R
Q
N
P
H
D
G
Site 2
T19
N
P
H
D
G
V
V
T
P
A
A
S
P
S
L
Site 3
S23
G
V
V
T
P
A
A
S
P
S
L
P
Q
P
G
Site 4
S25
V
T
P
A
A
S
P
S
L
P
Q
P
G
L
Q
Site 5
S47
V
Q
G
G
P
Q
P
S
G
Q
H
R
S
P
C
Site 6
S52
Q
P
S
G
Q
H
R
S
P
C
P
E
G
P
V
Site 7
T74
T
S
V
P
H
F
P
T
P
S
I
L
H
Q
G
Site 8
S76
V
P
H
F
P
T
P
S
I
L
H
Q
G
P
G
Site 9
S88
G
P
G
H
E
Q
H
S
P
L
V
A
P
P
A
Site 10
S99
A
P
P
A
A
L
P
S
D
G
R
D
E
V
S
Site 11
S106
S
D
G
R
D
E
V
S
H
L
Q
S
G
S
H
Site 12
S110
D
E
V
S
H
L
Q
S
G
S
H
L
A
N
N
Site 13
S118
G
S
H
L
A
N
N
S
D
P
E
S
T
F
R
Site 14
S122
A
N
N
S
D
P
E
S
T
F
R
Q
N
P
R
Site 15
T123
N
N
S
D
P
E
S
T
F
R
Q
N
P
R
I
Site 16
S136
R
I
V
N
H
W
A
S
P
E
L
R
Q
N
P
Site 17
S153
K
N
E
H
R
P
A
S
A
L
V
N
P
L
A
Site 18
S164
N
P
L
A
R
G
D
S
P
E
N
R
T
H
H
Site 19
T169
G
D
S
P
E
N
R
T
H
H
P
L
G
A
G
Site 20
S210
T
E
N
E
E
N
L
S
S
E
K
A
G
L
S
Site 21
S211
E
N
E
E
N
L
S
S
E
K
A
G
L
S
G
Site 22
S217
S
S
E
K
A
G
L
S
G
Q
A
D
F
D
D
Site 23
S227
A
D
F
D
D
F
C
S
S
P
G
L
G
R
P
Site 24
S228
D
F
D
D
F
C
S
S
P
G
L
G
R
P
P
Site 25
T238
L
G
R
P
P
A
P
T
H
V
G
A
G
S
L
Site 26
S254
Q
A
L
L
P
G
P
S
N
E
A
A
G
D
V
Site 27
T265
A
G
D
V
W
G
D
T
A
S
T
G
V
P
D
Site 28
S267
D
V
W
G
D
T
A
S
T
G
V
P
D
A
S
Site 29
S274
S
T
G
V
P
D
A
S
G
S
Q
Y
E
N
V
Site 30
S276
G
V
P
D
A
S
G
S
Q
Y
E
N
V
E
N
Site 31
Y278
P
D
A
S
G
S
Q
Y
E
N
V
E
N
L
E
Site 32
S295
Q
N
Q
E
V
L
P
S
E
P
L
N
L
D
P
Site 33
S303
E
P
L
N
L
D
P
S
S
P
S
D
Q
F
R
Site 34
S304
P
L
N
L
D
P
S
S
P
S
D
Q
F
R
Y
Site 35
Y311
S
P
S
D
Q
F
R
Y
G
P
L
P
G
P
A
Site 36
T334
H
T
G
A
P
D
A
T
L
H
T
V
H
P
D
Site 37
T337
A
P
D
A
T
L
H
T
V
H
P
D
S
V
S
Site 38
S342
L
H
T
V
H
P
D
S
V
S
S
S
Y
S
S
Site 39
S344
T
V
H
P
D
S
V
S
S
S
Y
S
S
R
S
Site 40
S345
V
H
P
D
S
V
S
S
S
Y
S
S
R
S
H
Site 41
S346
H
P
D
S
V
S
S
S
Y
S
S
R
S
H
G
Site 42
Y347
P
D
S
V
S
S
S
Y
S
S
R
S
H
G
R
Site 43
S348
D
S
V
S
S
S
Y
S
S
R
S
H
G
R
L
Site 44
S349
S
V
S
S
S
Y
S
S
R
S
H
G
R
L
S
Site 45
S351
S
S
S
Y
S
S
R
S
H
G
R
L
S
G
S
Site 46
S356
S
R
S
H
G
R
L
S
G
S
A
R
P
Q
E
Site 47
S358
S
H
G
R
L
S
G
S
A
R
P
Q
E
L
V
Site 48
T367
R
P
Q
E
L
V
G
T
F
I
Q
Q
E
V
G
Site 49
S381
G
K
P
E
D
E
A
S
G
S
F
F
K
Q
I
Site 50
S383
P
E
D
E
A
S
G
S
F
F
K
Q
I
D
S
Site 51
S390
S
F
F
K
Q
I
D
S
S
P
V
G
G
E
T
Site 52
S391
F
F
K
Q
I
D
S
S
P
V
G
G
E
T
D
Site 53
T397
S
S
P
V
G
G
E
T
D
E
T
T
V
S
Q
Site 54
T400
V
G
G
E
T
D
E
T
T
V
S
Q
N
Y
R
Site 55
T401
G
G
E
T
D
E
T
T
V
S
Q
N
Y
R
G
Site 56
S403
E
T
D
E
T
T
V
S
Q
N
Y
R
G
S
V
Site 57
Y406
E
T
T
V
S
Q
N
Y
R
G
S
V
S
Q
P
Site 58
S409
V
S
Q
N
Y
R
G
S
V
S
Q
P
S
T
P
Site 59
S411
Q
N
Y
R
G
S
V
S
Q
P
S
T
P
S
P
Site 60
S414
R
G
S
V
S
Q
P
S
T
P
S
P
P
K
P
Site 61
T415
G
S
V
S
Q
P
S
T
P
S
P
P
K
P
T
Site 62
S417
V
S
Q
P
S
T
P
S
P
P
K
P
T
G
I
Site 63
T422
T
P
S
P
P
K
P
T
G
I
F
Q
T
S
A
Site 64
T427
K
P
T
G
I
F
Q
T
S
A
N
S
S
F
E
Site 65
S428
P
T
G
I
F
Q
T
S
A
N
S
S
F
E
P
Site 66
S431
I
F
Q
T
S
A
N
S
S
F
E
P
V
K
S
Site 67
S432
F
Q
T
S
A
N
S
S
F
E
P
V
K
S
H
Site 68
S438
S
S
F
E
P
V
K
S
H
L
V
G
V
K
P
Site 69
T460
V
V
G
E
V
R
E
T
C
V
R
Q
K
Q
C
Site 70
S477
A
A
A
L
P
D
A
S
P
G
N
L
E
Q
P
Site 71
T521
A
G
A
P
P
L
D
T
V
Y
P
A
P
E
K
Site 72
Y523
A
P
P
L
D
T
V
Y
P
A
P
E
K
R
P
Site 73
S531
P
A
P
E
K
R
P
S
A
R
T
Q
G
P
V
Site 74
T534
E
K
R
P
S
A
R
T
Q
G
P
V
K
C
E
Site 75
S542
Q
G
P
V
K
C
E
S
P
A
T
T
L
W
A
Site 76
T545
V
K
C
E
S
P
A
T
T
L
W
A
Q
S
E
Site 77
T546
K
C
E
S
P
A
T
T
L
W
A
Q
S
E
L
Site 78
S551
A
T
T
L
W
A
Q
S
E
L
P
D
F
G
G
Site 79
S588
Q
P
P
E
E
A
M
S
G
Q
Q
S
R
N
P
Site 80
S592
E
A
M
S
G
Q
Q
S
R
N
P
S
S
A
A
Site 81
S596
G
Q
Q
S
R
N
P
S
S
A
A
P
V
Q
S
Site 82
S597
Q
Q
S
R
N
P
S
S
A
A
P
V
Q
S
R
Site 83
S603
S
S
A
A
P
V
Q
S
R
G
G
I
G
A
S
Site 84
S610
S
R
G
G
I
G
A
S
E
N
L
E
N
P
P
Site 85
S627
G
E
E
E
A
L
Q
S
Q
A
S
S
G
Y
A
Site 86
S630
E
A
L
Q
S
Q
A
S
S
G
Y
A
S
L
L
Site 87
S631
A
L
Q
S
Q
A
S
S
G
Y
A
S
L
L
S
Site 88
S635
Q
A
S
S
G
Y
A
S
L
L
S
S
P
P
T
Site 89
S638
S
G
Y
A
S
L
L
S
S
P
P
T
E
S
L
Site 90
S639
G
Y
A
S
L
L
S
S
P
P
T
E
S
L
Q
Site 91
T642
S
L
L
S
S
P
P
T
E
S
L
Q
N
P
P
Site 92
S644
L
S
S
P
P
T
E
S
L
Q
N
P
P
V
L
Site 93
Y659
I
A
Q
P
D
H
S
Y
N
L
A
Q
P
I
N
Site 94
S668
L
A
Q
P
I
N
F
S
V
S
L
S
N
S
H
Site 95
S670
Q
P
I
N
F
S
V
S
L
S
N
S
H
E
K
Site 96
S672
I
N
F
S
V
S
L
S
N
S
H
E
K
N
Q
Site 97
S674
F
S
V
S
L
S
N
S
H
E
K
N
Q
S
W
Site 98
S680
N
S
H
E
K
N
Q
S
W
R
E
A
L
V
G
Site 99
S693
V
G
D
R
P
A
V
S
S
W
A
L
G
G
D
Site 100
S694
G
D
R
P
A
V
S
S
W
A
L
G
G
D
S
Site 101
S701
S
W
A
L
G
G
D
S
G
E
N
T
S
L
S
Site 102
T705
G
G
D
S
G
E
N
T
S
L
S
G
I
P
T
Site 103
S706
G
D
S
G
E
N
T
S
L
S
G
I
P
T
S
Site 104
S708
S
G
E
N
T
S
L
S
G
I
P
T
S
S
V
Site 105
S727
L
P
S
S
V
A
Q
S
N
F
P
Q
G
S
G
Site 106
S733
Q
S
N
F
P
Q
G
S
G
A
S
E
M
V
S
Site 107
S740
S
G
A
S
E
M
V
S
N
Q
P
A
N
L
L
Site 108
S752
N
L
L
V
Q
P
P
S
Q
P
V
P
E
N
L
Site 109
S763
P
E
N
L
V
P
E
S
Q
K
D
R
K
A
G
Site 110
S779
A
L
P
G
F
A
N
S
P
A
G
S
T
S
V
Site 111
T784
A
N
S
P
A
G
S
T
S
V
V
L
V
P
P
Site 112
T795
L
V
P
P
A
H
G
T
L
V
P
D
G
N
K
Site 113
S806
D
G
N
K
A
N
H
S
S
H
Q
E
D
T
Y
Site 114
S807
G
N
K
A
N
H
S
S
H
Q
E
D
T
Y
G
Site 115
Y813
S
S
H
Q
E
D
T
Y
G
A
L
D
F
T
L
Site 116
T819
T
Y
G
A
L
D
F
T
L
S
R
T
L
E
N
Site 117
S821
G
A
L
D
F
T
L
S
R
T
L
E
N
P
V
Site 118
Y831
L
E
N
P
V
N
V
Y
N
P
S
H
S
D
S
Site 119
S834
P
V
N
V
Y
N
P
S
H
S
D
S
L
A
S
Site 120
S836
N
V
Y
N
P
S
H
S
D
S
L
A
S
Q
Q
Site 121
S838
Y
N
P
S
H
S
D
S
L
A
S
Q
Q
S
V
Site 122
S841
S
H
S
D
S
L
A
S
Q
Q
S
V
A
S
H
Site 123
S844
D
S
L
A
S
Q
Q
S
V
A
S
H
P
R
Q
Site 124
S847
A
S
Q
Q
S
V
A
S
H
P
R
Q
S
G
P
Site 125
S852
V
A
S
H
P
R
Q
S
G
P
G
A
P
N
L
Site 126
Y863
A
P
N
L
D
R
F
Y
Q
Q
V
T
K
D
A
Site 127
S891
V
P
P
Q
Q
Q
A
S
P
P
Q
L
P
K
A
Site 128
S901
Q
L
P
K
A
M
F
S
E
L
S
N
P
E
S
Site 129
S904
K
A
M
F
S
E
L
S
N
P
E
S
L
P
A
Site 130
S908
S
E
L
S
N
P
E
S
L
P
A
Q
G
Q
A
Site 131
S918
A
Q
G
Q
A
Q
N
S
A
Q
S
P
A
S
L
Site 132
S941
L
P
P
R
P
P
Q
S
S
S
V
S
L
V
S
Site 133
S942
P
P
R
P
P
Q
S
S
S
V
S
L
V
S
S
Site 134
S943
P
R
P
P
Q
S
S
S
V
S
L
V
S
S
G
Site 135
S945
P
P
Q
S
S
S
V
S
L
V
S
S
G
S
G
Site 136
S948
S
S
S
V
S
L
V
S
S
G
S
G
Q
A
A
Site 137
S958
S
G
Q
A
A
V
P
S
E
Q
P
W
P
Q
P
Site 138
Y981
P
P
Q
D
L
A
A
Y
Y
Y
Y
R
P
L
Y
Site 139
Y982
P
Q
D
L
A
A
Y
Y
Y
Y
R
P
L
Y
D
Site 140
Y983
Q
D
L
A
A
Y
Y
Y
Y
R
P
L
Y
D
A
Site 141
Y988
Y
Y
Y
Y
R
P
L
Y
D
A
Y
Q
P
Q
Y
Site 142
Y991
Y
R
P
L
Y
D
A
Y
Q
P
Q
Y
S
L
P
Site 143
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E
V
S
Q
Site 295
S2122
C
S
S
M
S
S
L
S
R
E
V
S
Q
H
F
Site 296
S2126
S
S
L
S
R
E
V
S
Q
H
F
N
Q
A
P
Site 297
S2144
P
A
A
G
G
P
P
S
G
A
M
P
F
Y
N
Site 298
Y2150
P
S
G
A
M
P
F
Y
N
P
A
Q
L
A
Q
Site 299
S2162
L
A
Q
A
C
A
T
S
G
S
S
R
L
G
R
Site 300
S2164
Q
A
C
A
T
S
G
S
S
R
L
G
R
I
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation