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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PLD2
Full Name:
Phospholipase D2
Alias:
Choline phosphatase 2; Phosphatidylcholine-hydrolyzing phospholipase D2; PLD 2; PLD1C
Type:
Lipid Metabolism - glycerophospholipid; Lipid Metabolism - ether lipid; Phospholipase; EC 3.1.4.4
Mass (Da):
105987
Number AA:
933
UniProt ID:
O14939
International Prot ID:
IPI00024727
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0019898
GO:0005794
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0070290
GO:0035091
GO:0004630
PhosphoSite+
KinaseNET
Biological Process:
GO:0007010
GO:0016042
GO:0007264
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
T
A
T
P
E
S
L
F
P
T
G
D
E
Site 2
T11
T
P
E
S
L
F
P
T
G
D
E
L
D
S
S
Site 3
S17
P
T
G
D
E
L
D
S
S
Q
L
Q
M
E
S
Site 4
S18
T
G
D
E
L
D
S
S
Q
L
Q
M
E
S
D
Site 5
S24
S
S
Q
L
Q
M
E
S
D
E
V
D
T
L
K
Site 6
T72
V
T
A
Q
V
V
G
T
E
R
Y
T
S
G
S
Site 7
Y75
Q
V
V
G
T
E
R
Y
T
S
G
S
K
V
G
Site 8
T76
V
V
G
T
E
R
Y
T
S
G
S
K
V
G
T
Site 9
S77
V
G
T
E
R
Y
T
S
G
S
K
V
G
T
C
Site 10
S79
T
E
R
Y
T
S
G
S
K
V
G
T
C
T
L
Site 11
T83
T
S
G
S
K
V
G
T
C
T
L
Y
S
V
R
Site 12
T92
T
L
Y
S
V
R
L
T
H
G
D
F
S
W
T
Site 13
S97
R
L
T
H
G
D
F
S
W
T
T
K
K
K
Y
Site 14
T99
T
H
G
D
F
S
W
T
T
K
K
K
Y
R
H
Site 15
T100
H
G
D
F
S
W
T
T
K
K
K
Y
R
H
F
Site 16
Y104
S
W
T
T
K
K
K
Y
R
H
F
Q
E
L
H
Site 17
S134
A
R
F
A
V
A
Y
S
P
A
R
D
A
G
N
Site 18
S146
A
G
N
R
E
M
P
S
L
P
R
A
G
P
E
Site 19
S155
P
R
A
G
P
E
G
S
T
R
H
A
A
S
K
Site 20
Y165
H
A
A
S
K
Q
K
Y
L
E
N
Y
L
N
R
Site 21
Y169
K
Q
K
Y
L
E
N
Y
L
N
R
L
L
T
M
Site 22
T175
N
Y
L
N
R
L
L
T
M
S
F
Y
R
N
Y
Site 23
Y179
R
L
L
T
M
S
F
Y
R
N
Y
H
A
M
T
Site 24
Y182
T
M
S
F
Y
R
N
Y
H
A
M
T
E
F
L
Site 25
S213
E
G
M
I
R
K
R
S
G
G
H
R
V
P
G
Site 26
T222
G
H
R
V
P
G
L
T
C
C
G
R
D
Q
V
Site 27
S243
R
W
L
V
V
K
D
S
F
L
L
Y
M
C
L
Site 28
T252
L
L
Y
M
C
L
E
T
G
A
I
S
F
V
Q
Site 29
T274
V
Q
V
G
K
R
S
T
E
A
R
H
G
V
R
Site 30
T284
R
H
G
V
R
I
D
T
S
H
R
S
L
I
L
Site 31
S285
H
G
V
R
I
D
T
S
H
R
S
L
I
L
K
Site 32
S288
R
I
D
T
S
H
R
S
L
I
L
K
C
S
S
Site 33
S294
R
S
L
I
L
K
C
S
S
Y
R
Q
A
R
W
Site 34
Y296
L
I
L
K
C
S
S
Y
R
Q
A
R
W
W
A
Site 35
S325
L
Q
L
H
R
H
D
S
Y
A
P
P
R
P
G
Site 36
Y326
Q
L
H
R
H
D
S
Y
A
P
P
R
P
G
T
Site 37
T333
Y
A
P
P
R
P
G
T
L
A
R
W
F
V
N
Site 38
Y371
W
W
L
S
P
E
V
Y
L
K
R
P
A
H
S
Site 39
S378
Y
L
K
R
P
A
H
S
D
D
W
R
L
D
I
Site 40
Y415
A
L
G
I
N
S
G
Y
S
K
R
A
L
M
L
Site 41
S416
L
G
I
N
S
G
Y
S
K
R
A
L
M
L
L
Site 42
Y462
L
G
G
L
D
L
A
Y
G
R
W
D
D
L
H
Site 43
Y470
G
R
W
D
D
L
H
Y
R
L
T
D
L
G
D
Site 44
T473
D
D
L
H
Y
R
L
T
D
L
G
D
S
S
E
Site 45
S478
R
L
T
D
L
G
D
S
S
E
S
A
A
S
Q
Site 46
S479
L
T
D
L
G
D
S
S
E
S
A
A
S
Q
P
Site 47
S481
D
L
G
D
S
S
E
S
A
A
S
Q
P
P
T
Site 48
S484
D
S
S
E
S
A
A
S
Q
P
P
T
P
R
P
Site 49
T488
S
A
A
S
Q
P
P
T
P
R
P
D
S
P
A
Site 50
S493
P
P
T
P
R
P
D
S
P
A
T
P
D
L
S
Site 51
T496
P
R
P
D
S
P
A
T
P
D
L
S
H
N
Q
Site 52
Y511
F
F
W
L
G
K
D
Y
S
N
L
I
T
K
D
Site 53
T516
K
D
Y
S
N
L
I
T
K
D
W
V
Q
L
D
Site 54
T534
E
D
F
I
D
R
E
T
T
P
R
M
P
W
R
Site 55
T535
D
F
I
D
R
E
T
T
P
R
M
P
W
R
D
Site 56
T566
F
I
Q
R
W
N
F
T
K
T
T
K
A
K
Y
Site 57
Y573
T
K
T
T
K
A
K
Y
K
T
P
T
Y
P
Y
Site 58
T575
T
T
K
A
K
Y
K
T
P
T
Y
P
Y
L
L
Site 59
Y578
A
K
Y
K
T
P
T
Y
P
Y
L
L
P
K
S
Site 60
Y580
Y
K
T
P
T
Y
P
Y
L
L
P
K
S
T
S
Site 61
S585
Y
P
Y
L
L
P
K
S
T
S
T
A
N
Q
L
Site 62
S587
Y
L
L
P
K
S
T
S
T
A
N
Q
L
P
F
Site 63
T595
T
A
N
Q
L
P
F
T
L
P
G
G
Q
C
T
Site 64
S609
T
T
V
Q
V
L
R
S
V
D
R
W
S
A
G
Site 65
S614
L
R
S
V
D
R
W
S
A
G
T
L
E
N
S
Site 66
T617
V
D
R
W
S
A
G
T
L
E
N
S
I
L
N
Site 67
S621
S
A
G
T
L
E
N
S
I
L
N
A
Y
L
H
Site 68
T629
I
L
N
A
Y
L
H
T
I
R
E
S
Q
H
F
Site 69
Y638
R
E
S
Q
H
F
L
Y
I
E
N
Q
F
F
I
Site 70
S646
I
E
N
Q
F
F
I
S
C
S
D
G
R
T
V
Site 71
T652
I
S
C
S
D
G
R
T
V
L
N
K
V
G
D
Site 72
Y675
A
H
K
Q
G
W
C
Y
R
V
Y
V
L
L
P
Site 73
S692
P
G
F
E
G
D
I
S
T
G
G
G
N
S
I
Site 74
T693
G
F
E
G
D
I
S
T
G
G
G
N
S
I
Q
Site 75
T709
I
L
H
F
T
Y
R
T
L
C
R
G
E
Y
S
Site 76
Y715
R
T
L
C
R
G
E
Y
S
I
L
H
R
L
K
Site 77
S750
E
L
G
G
H
P
V
S
E
L
I
Y
I
H
S
Site 78
S778
S
A
N
I
N
D
R
S
L
L
G
K
R
D
S
Site 79
T796
V
L
I
E
D
T
E
T
E
P
S
L
M
N
G
Site 80
S799
E
D
T
E
T
E
P
S
L
M
N
G
A
E
Y
Site 81
Y806
S
L
M
N
G
A
E
Y
Q
A
G
R
F
A
L
Site 82
S814
Q
A
G
R
F
A
L
S
L
R
K
H
C
F
G
Site 83
Y857
A
E
S
N
A
N
I
Y
E
Q
I
F
R
C
L
Site 84
S871
L
P
S
N
A
T
R
S
L
R
T
L
R
E
Y
Site 85
T874
N
A
T
R
S
L
R
T
L
R
E
Y
V
A
V
Site 86
S888
V
E
P
L
A
T
V
S
P
P
L
A
R
S
E
Site 87
S894
V
S
P
P
L
A
R
S
E
L
T
Q
V
Q
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation