KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
RasGRF2
Full Name:
Ras-specific guanine nucleotide-releasing factor 2
Alias:
GRF2; Guanine nucleotide-releasing factor 2; Ras guanine nucleotide exchange factor 2; Ras protein-specific guanine nucleotide-releasing factor 2; Ras-GRF2; RGRF2
Type:
Intracellular, Cytoplasm, Plasma membrane, Endoplasmic reticulum, Endoplasmic reticulum membrane protein
Mass (Da):
140764
Number AA:
1237
UniProt ID:
O14827
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005783
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0005089
GO:0005509
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0008624
GO:0035023
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y14
Y
N
E
G
H
A
L
Y
L
A
F
L
A
R
K
Site 2
T24
F
L
A
R
K
E
G
T
K
R
G
F
L
S
K
Site 3
S30
G
T
K
R
G
F
L
S
K
K
T
A
E
A
S
Site 4
T33
R
G
F
L
S
K
K
T
A
E
A
S
R
W
H
Site 5
S37
S
K
K
T
A
E
A
S
R
W
H
E
K
W
F
Site 6
Y53
L
Y
Q
N
V
L
F
Y
F
E
G
E
Q
S
C
Site 7
S72
M
Y
L
L
E
G
C
S
C
E
R
T
P
A
P
Site 8
T76
E
G
C
S
C
E
R
T
P
A
P
P
R
A
G
Site 9
Y97
R
D
A
L
D
K
Q
Y
Y
F
T
V
L
F
G
Site 10
Y98
D
A
L
D
K
Q
Y
Y
F
T
V
L
F
G
H
Site 11
T100
L
D
K
Q
Y
Y
F
T
V
L
F
G
H
E
G
Site 12
T173
H
Q
L
E
D
Q
D
T
E
I
E
R
L
K
S
Site 13
S180
T
E
I
E
R
L
K
S
E
I
I
A
L
N
K
Site 14
T188
E
I
I
A
L
N
K
T
K
E
R
M
R
P
Y
Site 15
Y195
T
K
E
R
M
R
P
Y
Q
S
N
Q
E
D
E
Site 16
T227
L
C
R
R
K
W
K
T
I
V
Q
D
Y
I
C
Site 17
Y232
W
K
T
I
V
Q
D
Y
I
C
S
P
H
A
E
Site 18
S278
R
P
L
R
M
A
A
S
S
K
K
P
P
I
S
Site 19
S279
P
L
R
M
A
A
S
S
K
K
P
P
I
S
H
Site 20
S285
S
S
K
K
P
P
I
S
H
D
D
V
S
S
I
Site 21
S290
P
I
S
H
D
D
V
S
S
I
F
L
N
S
E
Site 22
Y336
L
L
P
M
L
N
I
Y
Q
E
F
V
R
N
H
Site 23
T402
L
H
E
L
L
A
H
T
P
H
E
H
V
E
R
Site 24
S411
H
E
H
V
E
R
K
S
L
E
F
A
K
S
K
Site 25
S417
K
S
L
E
F
A
K
S
K
L
E
E
L
S
R
Site 26
S431
R
V
M
H
D
E
V
S
D
T
E
N
I
R
K
Site 27
T433
M
H
D
E
V
S
D
T
E
N
I
R
K
N
L
Site 28
T456
G
C
D
I
L
L
D
T
S
Q
T
F
I
R
Q
Site 29
S457
C
D
I
L
L
D
T
S
Q
T
F
I
R
Q
G
Site 30
S465
Q
T
F
I
R
Q
G
S
L
I
Q
V
P
S
V
Site 31
S471
G
S
L
I
Q
V
P
S
V
E
R
G
K
L
S
Site 32
S478
S
V
E
R
G
K
L
S
K
V
R
L
G
S
L
Site 33
S484
L
S
K
V
R
L
G
S
L
S
L
K
K
E
G
Site 34
S486
K
V
R
L
G
S
L
S
L
K
K
E
G
E
R
Site 35
T506
T
K
H
F
L
I
C
T
R
S
S
G
G
K
L
Site 36
S536
L
I
E
E
P
D
A
S
D
D
D
S
K
G
S
Site 37
S540
P
D
A
S
D
D
D
S
K
G
S
G
Q
V
F
Site 38
S543
S
D
D
D
S
K
G
S
G
Q
V
F
G
H
L
Site 39
S614
T
V
P
H
M
I
K
S
D
A
R
L
H
K
D
Site 40
T623
A
R
L
H
K
D
D
T
D
I
C
F
S
K
T
Site 41
T630
T
D
I
C
F
S
K
T
L
N
S
C
K
V
P
Site 42
S633
C
F
S
K
T
L
N
S
C
K
V
P
Q
I
R
Site 43
S643
V
P
Q
I
R
Y
A
S
V
E
R
L
L
E
R
Site 44
T652
E
R
L
L
E
R
L
T
D
L
R
F
L
S
I
Site 45
Y686
L
G
K
L
S
D
I
Y
K
R
P
F
T
S
I
Site 46
T691
D
I
Y
K
R
P
F
T
S
I
P
V
R
S
L
Site 47
S705
L
E
L
F
F
A
T
S
Q
N
N
R
G
E
H
Site 48
S718
E
H
L
V
D
G
K
S
P
R
L
C
R
K
F
Site 49
S726
P
R
L
C
R
K
F
S
S
P
P
P
L
A
V
Site 50
S727
R
L
C
R
K
F
S
S
P
P
P
L
A
V
S
Site 51
S734
S
P
P
P
L
A
V
S
R
T
S
S
P
V
R
Site 52
T736
P
P
L
A
V
S
R
T
S
S
P
V
R
A
R
Site 53
S737
P
L
A
V
S
R
T
S
S
P
V
R
A
R
K
Site 54
S738
L
A
V
S
R
T
S
S
P
V
R
A
R
K
L
Site 55
S746
P
V
R
A
R
K
L
S
L
T
S
P
L
N
S
Site 56
T748
R
A
R
K
L
S
L
T
S
P
L
N
S
K
I
Site 57
S749
A
R
K
L
S
L
T
S
P
L
N
S
K
I
G
Site 58
T761
K
I
G
A
L
D
L
T
T
S
S
S
P
T
T
Site 59
T762
I
G
A
L
D
L
T
T
S
S
S
P
T
T
T
Site 60
S763
G
A
L
D
L
T
T
S
S
S
P
T
T
T
T
Site 61
S764
A
L
D
L
T
T
S
S
S
P
T
T
T
T
Q
Site 62
S765
L
D
L
T
T
S
S
S
P
T
T
T
T
Q
S
Site 63
T767
L
T
T
S
S
S
P
T
T
T
T
Q
S
P
A
Site 64
T768
T
T
S
S
S
P
T
T
T
T
Q
S
P
A
A
Site 65
T769
T
S
S
S
P
T
T
T
T
Q
S
P
A
A
S
Site 66
T770
S
S
S
P
T
T
T
T
Q
S
P
A
A
S
P
Site 67
S772
S
P
T
T
T
T
Q
S
P
A
A
S
P
P
P
Site 68
S776
T
T
Q
S
P
A
A
S
P
P
P
H
T
G
Q
Site 69
S789
G
Q
I
P
L
D
L
S
R
G
L
S
S
P
E
Site 70
S793
L
D
L
S
R
G
L
S
S
P
E
Q
S
P
G
Site 71
S794
D
L
S
R
G
L
S
S
P
E
Q
S
P
G
T
Site 72
S798
G
L
S
S
P
E
Q
S
P
G
T
V
E
E
N
Site 73
T801
S
P
E
Q
S
P
G
T
V
E
E
N
V
D
N
Site 74
S838
A
D
R
A
G
V
E
S
S
P
A
A
D
T
T
Site 75
S839
D
R
A
G
V
E
S
S
P
A
A
D
T
T
E
Site 76
T844
E
S
S
P
A
A
D
T
T
E
L
S
P
C
R
Site 77
T845
S
S
P
A
A
D
T
T
E
L
S
P
C
R
S
Site 78
S848
A
A
D
T
T
E
L
S
P
C
R
S
P
S
T
Site 79
S852
T
E
L
S
P
C
R
S
P
S
T
P
R
H
L
Site 80
S854
L
S
P
C
R
S
P
S
T
P
R
H
L
R
Y
Site 81
T855
S
P
C
R
S
P
S
T
P
R
H
L
R
Y
R
Site 82
Y861
S
T
P
R
H
L
R
Y
R
Q
P
G
G
Q
T
Site 83
S875
T
A
D
N
A
H
C
S
V
S
P
A
S
A
F
Site 84
S893
T
A
A
A
G
H
G
S
P
P
G
F
N
N
T
Site 85
T900
S
P
P
G
F
N
N
T
E
R
T
C
D
K
E
Site 86
T913
K
E
F
I
I
R
R
T
A
T
N
R
V
L
N
Site 87
S972
A
N
I
L
R
A
L
S
Q
D
D
Q
D
D
I
Site 88
S1002
A
E
C
F
E
S
L
S
A
M
E
L
A
E
Q
Site 89
T1040
K
L
D
K
N
E
R
T
P
Y
I
M
K
T
S
Site 90
Y1042
D
K
N
E
R
T
P
Y
I
M
K
T
S
Q
H
Site 91
Y1064
V
A
S
Q
I
M
N
Y
A
D
V
S
S
R
A
Site 92
Y1090
I
C
R
C
L
H
N
Y
N
G
V
L
E
I
T
Site 93
Y1106
A
L
N
R
S
A
I
Y
R
L
K
K
T
W
A
Site 94
T1111
A
I
Y
R
L
K
K
T
W
A
K
V
S
K
Q
Site 95
T1129
L
M
D
K
L
Q
K
T
V
S
S
E
G
R
F
Site 96
S1131
D
K
L
Q
K
T
V
S
S
E
G
R
F
K
N
Site 97
S1132
K
L
Q
K
T
V
S
S
E
G
R
F
K
N
L
Site 98
T1142
R
F
K
N
L
R
E
T
L
K
N
C
N
P
P
Site 99
T1168
L
A
F
I
E
E
G
T
P
N
F
T
E
E
G
Site 100
T1198
E
I
R
Q
F
Q
Q
T
S
Y
R
I
D
H
Q
Site 101
T1223
D
L
I
I
D
E
D
T
L
Y
E
L
S
L
K
Site 102
Y1225
I
I
D
E
D
T
L
Y
E
L
S
L
K
I
E
Site 103
S1228
E
D
T
L
Y
E
L
S
L
K
I
E
P
R
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation