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Updated November 2019
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Protein Info
Short Name:
SNX26
Full Name:
Rho GTPase-activating protein 33
Alias:
FLJ39019; Sorting nexin 26; Sorting nexin-26; TCGAP
Type:
GTPase-activating protein for Rac/Rho
Mass (Da):
137213
Number AA:
1287
UniProt ID:
O14559
International Prot ID:
IPI00549274
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0035091
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0015031
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T6
_
_
M
V
A
R
S
T
D
S
L
D
G
P
G
Site 2
S8
M
V
A
R
S
T
D
S
L
D
G
P
G
E
G
Site 3
S16
L
D
G
P
G
E
G
S
V
Q
P
L
P
T
A
Site 4
S27
L
P
T
A
G
G
P
S
V
K
G
K
P
G
K
Site 5
S37
G
K
P
G
K
R
L
S
A
P
R
G
P
F
P
Site 6
S67
G
H
I
Q
L
L
L
S
P
D
R
E
G
P
S
Site 7
S74
S
P
D
R
E
G
P
S
L
S
G
E
N
E
L
Site 8
S76
D
R
E
G
P
S
L
S
G
E
N
E
L
V
F
Site 9
S99
R
S
W
P
V
L
R
S
Y
D
D
F
R
S
L
Site 10
Y100
S
W
P
V
L
R
S
Y
D
D
F
R
S
L
D
Site 11
S105
R
S
Y
D
D
F
R
S
L
D
A
H
L
H
R
Site 12
S120
C
I
F
D
R
R
F
S
C
L
P
E
L
P
P
Site 13
S178
H
G
R
R
L
L
L
S
E
E
A
S
L
N
I
Site 14
T198
A
H
V
I
K
R
Y
T
A
Q
A
P
D
E
L
Site 15
T247
S
E
C
V
E
L
F
T
E
R
P
G
P
G
L
Site 16
S273
P
A
P
Q
G
I
S
S
L
T
S
A
V
P
R
Site 17
S276
Q
G
I
S
S
L
T
S
A
V
P
R
P
R
G
Site 18
T291
K
L
A
G
L
L
R
T
F
M
R
S
R
P
S
Site 19
S295
L
L
R
T
F
M
R
S
R
P
S
R
Q
R
L
Site 20
S298
T
F
M
R
S
R
P
S
R
Q
R
L
R
Q
R
Site 21
S322
C
D
L
G
E
H
L
S
N
S
G
Q
D
V
P
Site 22
S324
L
G
E
H
L
S
N
S
G
Q
D
V
P
Q
V
Site 23
S336
P
Q
V
L
R
C
C
S
E
F
I
E
A
H
G
Site 24
S352
V
D
G
I
Y
R
L
S
G
V
S
S
N
I
Q
Site 25
S355
I
Y
R
L
S
G
V
S
S
N
I
Q
R
L
R
Site 26
S356
Y
R
L
S
G
V
S
S
N
I
Q
R
L
R
H
Site 27
S367
R
L
R
H
E
F
D
S
E
R
I
P
E
L
S
Site 28
S374
S
E
R
I
P
E
L
S
G
P
A
F
L
Q
D
Site 29
S387
Q
D
I
H
S
V
S
S
L
C
K
L
Y
F
R
Site 30
Y392
V
S
S
L
C
K
L
Y
F
R
E
L
P
N
P
Site 31
Y403
L
P
N
P
L
L
T
Y
Q
L
Y
G
K
F
S
Site 32
Y406
P
L
L
T
Y
Q
L
Y
G
K
F
S
E
A
M
Site 33
S410
Y
Q
L
Y
G
K
F
S
E
A
M
S
V
P
G
Site 34
S414
G
K
F
S
E
A
M
S
V
P
G
E
E
E
R
Site 35
Y437
Q
Q
L
P
P
P
H
Y
R
T
L
E
Y
L
L
Site 36
Y442
P
H
Y
R
T
L
E
Y
L
L
R
H
L
A
R
Site 37
S454
L
A
R
M
A
R
H
S
A
N
T
S
M
H
A
Site 38
S458
A
R
H
S
A
N
T
S
M
H
A
R
N
L
A
Site 39
S475
W
A
P
N
L
L
R
S
M
E
L
E
S
V
G
Site 40
S532
C
L
L
P
R
P
K
S
L
A
G
S
C
P
S
Site 41
S536
R
P
K
S
L
A
G
S
C
P
S
T
R
L
L
Site 42
T544
C
P
S
T
R
L
L
T
L
E
E
A
Q
A
R
Site 43
T552
L
E
E
A
Q
A
R
T
Q
G
R
L
G
T
P
Site 44
T558
R
T
Q
G
R
L
G
T
P
T
E
P
T
T
P
Site 45
T560
Q
G
R
L
G
T
P
T
E
P
T
T
P
K
A
Site 46
T564
G
T
P
T
E
P
T
T
P
K
A
P
A
S
P
Site 47
S570
T
T
P
K
A
P
A
S
P
A
E
R
R
K
G
Site 48
S589
K
Q
R
K
P
G
G
S
S
W
K
T
F
F
A
Site 49
T593
P
G
G
S
S
W
K
T
F
F
A
L
G
R
G
Site 50
S602
F
A
L
G
R
G
P
S
V
P
R
K
K
P
L
Site 51
S622
T
R
A
P
P
Q
P
S
G
S
R
P
D
T
V
Site 52
S624
A
P
P
Q
P
S
G
S
R
P
D
T
V
T
L
Site 53
T628
P
S
G
S
R
P
D
T
V
T
L
R
S
A
K
Site 54
T630
G
S
R
P
D
T
V
T
L
R
S
A
K
S
E
Site 55
S633
P
D
T
V
T
L
R
S
A
K
S
E
E
S
L
Site 56
S636
V
T
L
R
S
A
K
S
E
E
S
L
S
S
Q
Site 57
S639
R
S
A
K
S
E
E
S
L
S
S
Q
A
S
G
Site 58
S641
A
K
S
E
E
S
L
S
S
Q
A
S
G
A
G
Site 59
S642
K
S
E
E
S
L
S
S
Q
A
S
G
A
G
L
Site 60
S645
E
S
L
S
S
Q
A
S
G
A
G
L
Q
R
L
Site 61
S660
H
R
L
R
R
P
H
S
S
S
D
A
F
P
V
Site 62
S661
R
L
R
R
P
H
S
S
S
D
A
F
P
V
G
Site 63
S662
L
R
R
P
H
S
S
S
D
A
F
P
V
G
P
Site 64
S674
V
G
P
A
P
A
G
S
C
E
S
L
S
S
S
Site 65
S677
A
P
A
G
S
C
E
S
L
S
S
S
S
S
S
Site 66
S679
A
G
S
C
E
S
L
S
S
S
S
S
S
E
S
Site 67
S680
G
S
C
E
S
L
S
S
S
S
S
S
E
S
S
Site 68
S681
S
C
E
S
L
S
S
S
S
S
S
E
S
S
S
Site 69
S682
C
E
S
L
S
S
S
S
S
S
E
S
S
S
S
Site 70
S683
E
S
L
S
S
S
S
S
S
E
S
S
S
S
E
Site 71
S684
S
L
S
S
S
S
S
S
E
S
S
S
S
E
S
Site 72
S686
S
S
S
S
S
S
E
S
S
S
S
E
S
S
S
Site 73
S687
S
S
S
S
S
E
S
S
S
S
E
S
S
S
S
Site 74
S688
S
S
S
S
E
S
S
S
S
E
S
S
S
S
S
Site 75
S689
S
S
S
E
S
S
S
S
E
S
S
S
S
S
S
Site 76
S691
S
E
S
S
S
S
E
S
S
S
S
S
S
E
S
Site 77
S692
E
S
S
S
S
E
S
S
S
S
S
S
E
S
S
Site 78
S693
S
S
S
S
E
S
S
S
S
S
S
E
S
S
A
Site 79
S694
S
S
S
E
S
S
S
S
S
S
E
S
S
A
A
Site 80
S695
S
S
E
S
S
S
S
S
S
E
S
S
A
A
G
Site 81
S696
S
E
S
S
S
S
S
S
E
S
S
A
A
G
L
Site 82
S698
S
S
S
S
S
S
E
S
S
A
A
G
L
G
A
Site 83
S699
S
S
S
S
S
E
S
S
A
A
G
L
G
A
L
Site 84
S707
A
A
G
L
G
A
L
S
G
S
P
S
H
R
T
Site 85
S709
G
L
G
A
L
S
G
S
P
S
H
R
T
S
A
Site 86
S711
G
A
L
S
G
S
P
S
H
R
T
S
A
W
L
Site 87
S715
G
S
P
S
H
R
T
S
A
W
L
D
D
G
D
Site 88
S727
D
G
D
E
L
D
F
S
P
P
R
C
L
E
G
Site 89
T744
G
L
D
F
D
P
L
T
F
R
C
S
S
P
T
Site 90
S748
D
P
L
T
F
R
C
S
S
P
T
P
G
D
P
Site 91
S749
P
L
T
F
R
C
S
S
P
T
P
G
D
P
A
Site 92
T751
T
F
R
C
S
S
P
T
P
G
D
P
A
P
P
Site 93
S760
G
D
P
A
P
P
A
S
P
A
P
P
A
P
A
Site 94
S768
P
A
P
P
A
P
A
S
A
F
P
P
R
V
T
Site 95
T775
S
A
F
P
P
R
V
T
P
Q
A
I
S
P
R
Site 96
S780
R
V
T
P
Q
A
I
S
P
R
G
P
T
S
P
Site 97
T785
A
I
S
P
R
G
P
T
S
P
A
S
P
A
A
Site 98
S786
I
S
P
R
G
P
T
S
P
A
S
P
A
A
L
Site 99
S789
R
G
P
T
S
P
A
S
P
A
A
L
D
I
S
Site 100
T821
G
G
A
P
A
S
A
T
P
T
P
A
L
S
P
Site 101
T823
A
P
A
S
A
T
P
T
P
A
L
S
P
G
R
Site 102
S827
A
T
P
T
P
A
L
S
P
G
R
S
L
R
P
Site 103
S831
P
A
L
S
P
G
R
S
L
R
P
H
L
I
P
Site 104
T849
R
G
A
E
A
P
L
T
D
A
C
Q
Q
E
M
Site 105
S873
P
L
G
P
D
M
E
S
P
L
P
P
P
P
L
Site 106
S881
P
L
P
P
P
P
L
S
L
L
R
P
G
G
A
Site 107
T923
S
Q
Q
E
C
G
G
T
P
P
A
S
Q
S
P
Site 108
S927
C
G
G
T
P
P
A
S
Q
S
P
F
H
R
S
Site 109
S929
G
T
P
P
A
S
Q
S
P
F
H
R
S
L
S
Site 110
S934
S
Q
S
P
F
H
R
S
L
S
L
E
V
G
G
Site 111
S936
S
P
F
H
R
S
L
S
L
E
V
G
G
E
P
Site 112
T946
V
G
G
E
P
L
G
T
S
G
S
G
P
P
P
Site 113
S947
G
G
E
P
L
G
T
S
G
S
G
P
P
P
N
Site 114
S949
E
P
L
G
T
S
G
S
G
P
P
P
N
S
L
Site 115
S955
G
S
G
P
P
P
N
S
L
A
H
P
G
A
W
Site 116
Y969
W
V
P
G
P
P
P
Y
L
P
R
Q
Q
S
D
Site 117
S975
P
Y
L
P
R
Q
Q
S
D
G
S
L
L
R
S
Site 118
S978
P
R
Q
Q
S
D
G
S
L
L
R
S
Q
R
P
Site 119
S982
S
D
G
S
L
L
R
S
Q
R
P
M
G
T
S
Site 120
T988
R
S
Q
R
P
M
G
T
S
R
R
G
L
R
G
Site 121
S989
S
Q
R
P
M
G
T
S
R
R
G
L
R
G
P
Site 122
S1019
A
P
E
A
A
A
Q
S
P
C
S
V
P
S
Q
Site 123
S1022
A
A
A
Q
S
P
C
S
V
P
S
Q
V
P
T
Site 124
S1025
Q
S
P
C
S
V
P
S
Q
V
P
T
P
G
F
Site 125
T1029
S
V
P
S
Q
V
P
T
P
G
F
F
S
P
A
Site 126
Y1053
G
V
P
K
P
G
L
Y
P
L
G
P
P
S
F
Site 127
S1059
L
Y
P
L
G
P
P
S
F
Q
P
S
S
P
A
Site 128
S1063
G
P
P
S
F
Q
P
S
S
P
A
P
V
W
R
Site 129
S1064
P
P
S
F
Q
P
S
S
P
A
P
V
W
R
S
Site 130
S1072
P
A
P
V
W
R
S
S
L
G
P
P
A
P
L
Site 131
Y1086
L
D
R
G
E
N
L
Y
Y
E
I
G
A
S
E
Site 132
Y1087
D
R
G
E
N
L
Y
Y
E
I
G
A
S
E
G
Site 133
S1092
L
Y
Y
E
I
G
A
S
E
G
S
P
Y
S
G
Site 134
S1095
E
I
G
A
S
E
G
S
P
Y
S
G
P
T
R
Site 135
Y1097
G
A
S
E
G
S
P
Y
S
G
P
T
R
S
W
Site 136
S1098
A
S
E
G
S
P
Y
S
G
P
T
R
S
W
S
Site 137
T1101
G
S
P
Y
S
G
P
T
R
S
W
S
P
F
R
Site 138
S1103
P
Y
S
G
P
T
R
S
W
S
P
F
R
S
M
Site 139
S1105
S
G
P
T
R
S
W
S
P
F
R
S
M
P
P
Site 140
S1109
R
S
W
S
P
F
R
S
M
P
P
D
R
L
N
Site 141
S1118
P
P
D
R
L
N
A
S
Y
G
M
L
G
Q
S
Site 142
Y1119
P
D
R
L
N
A
S
Y
G
M
L
G
Q
S
P
Site 143
S1125
S
Y
G
M
L
G
Q
S
P
P
L
H
R
S
P
Site 144
S1131
Q
S
P
P
L
H
R
S
P
D
F
L
L
S
Y
Site 145
S1137
R
S
P
D
F
L
L
S
Y
P
P
A
P
S
C
Site 146
S1143
L
S
Y
P
P
A
P
S
C
F
P
P
D
H
L
Site 147
Y1152
F
P
P
D
H
L
G
Y
S
A
P
Q
H
P
A
Site 148
S1153
P
P
D
H
L
G
Y
S
A
P
Q
H
P
A
R
Site 149
T1163
Q
H
P
A
R
R
P
T
P
P
E
P
L
Y
V
Site 150
Y1169
P
T
P
P
E
P
L
Y
V
N
L
A
L
G
P
Site 151
S1180
A
L
G
P
R
G
P
S
P
A
S
S
S
S
S
Site 152
S1183
P
R
G
P
S
P
A
S
S
S
S
S
S
P
P
Site 153
S1184
R
G
P
S
P
A
S
S
S
S
S
S
P
P
A
Site 154
S1185
G
P
S
P
A
S
S
S
S
S
S
P
P
A
H
Site 155
S1186
P
S
P
A
S
S
S
S
S
S
P
P
A
H
P
Site 156
S1187
S
P
A
S
S
S
S
S
S
P
P
A
H
P
R
Site 157
S1188
P
A
S
S
S
S
S
S
P
P
A
H
P
R
S
Site 158
S1195
S
P
P
A
H
P
R
S
R
S
D
P
G
P
P
Site 159
S1197
P
A
H
P
R
S
R
S
D
P
G
P
P
V
P
Site 160
T1218
R
A
P
W
G
P
R
T
P
H
R
V
P
G
P
Site 161
Y1235
P
P
E
P
L
L
L
Y
R
A
A
P
P
A
Y
Site 162
Y1242
Y
R
A
A
P
P
A
Y
G
R
G
G
E
L
H
Site 163
S1252
G
G
E
L
H
R
G
S
L
Y
R
N
G
G
Q
Site 164
Y1254
E
L
H
R
G
S
L
Y
R
N
G
G
Q
R
G
Site 165
Y1270
G
A
G
P
P
P
P
Y
P
T
P
S
W
S
L
Site 166
T1272
G
P
P
P
P
Y
P
T
P
S
W
S
L
H
S
Site 167
S1274
P
P
P
Y
P
T
P
S
W
S
L
H
S
E
G
Site 168
S1276
P
Y
P
T
P
S
W
S
L
H
S
E
G
Q
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation