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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
APS
Full Name:
SH2B adapter protein 2
Alias:
Adapter protein with pleckstrin homology and Src homology 2 domains; Adaptor protein with pleckstriny and src; SH2 and PH domain-containing adapter protein APS; SH2B adaptor protein 2; SH2B2
Type:
Adapter/scaffold protein
Mass (Da):
67738
Number AA:
632
UniProt ID:
O14492
International Prot ID:
IPI00155706
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0008269
GO:0005070
PhosphoSite+
KinaseNET
Biological Process:
GO:0008286
GO:0007242
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y52
F
L
R
D
N
P
A
Y
D
T
P
D
A
G
A
Site 2
T54
R
D
N
P
A
Y
D
T
P
D
A
G
A
S
F
Site 3
S60
D
T
P
D
A
G
A
S
F
S
R
H
F
A
A
Site 4
S62
P
D
A
G
A
S
F
S
R
H
F
A
A
N
F
Site 5
S93
T
T
R
G
A
A
V
S
A
E
A
M
E
P
E
Site 6
T104
M
E
P
E
L
A
D
T
S
A
L
K
A
A
P
Site 7
Y112
S
A
L
K
A
A
P
Y
G
H
S
R
S
S
E
Site 8
S117
A
P
Y
G
H
S
R
S
S
E
D
V
S
T
H
Site 9
S118
P
Y
G
H
S
R
S
S
E
D
V
S
T
H
A
Site 10
S122
S
R
S
S
E
D
V
S
T
H
A
A
T
K
A
Site 11
T123
R
S
S
E
D
V
S
T
H
A
A
T
K
A
R
Site 12
T127
D
V
S
T
H
A
A
T
K
A
R
V
R
K
G
Site 13
S136
A
R
V
R
K
G
F
S
L
R
N
M
S
L
C
Site 14
S157
D
M
W
H
R
R
A
S
P
E
P
D
A
A
A
Site 15
T168
D
A
A
A
A
P
R
T
A
E
P
R
D
K
W
Site 16
T176
A
E
P
R
D
K
W
T
R
R
L
R
L
S
R
Site 17
S182
W
T
R
R
L
R
L
S
R
T
L
A
A
K
V
Site 18
T184
R
R
L
R
L
S
R
T
L
A
A
K
V
E
L
Site 19
S245
F
F
V
P
P
K
A
S
R
P
K
V
S
I
P
Site 20
T273
E
M
P
E
K
D
N
T
F
V
L
K
V
E
N
Site 21
S310
G
C
V
D
P
G
D
S
E
E
D
T
E
L
S
Site 22
T314
P
G
D
S
E
E
D
T
E
L
S
C
T
R
G
Site 23
S317
S
E
E
D
T
E
L
S
C
T
R
G
G
C
L
Site 24
T319
E
D
T
E
L
S
C
T
R
G
G
C
L
A
S
Site 25
T348
D
L
P
R
P
P
E
T
T
A
V
G
A
V
V
Site 26
S360
A
V
V
T
A
P
H
S
R
G
R
D
A
V
R
Site 27
S369
G
R
D
A
V
R
E
S
L
I
H
V
P
L
E
Site 28
T381
P
L
E
T
F
L
Q
T
L
E
S
P
G
G
S
Site 29
S384
T
F
L
Q
T
L
E
S
P
G
G
S
G
S
D
Site 30
S388
T
L
E
S
P
G
G
S
G
S
D
S
N
N
T
Site 31
S390
E
S
P
G
G
S
G
S
D
S
N
N
T
G
E
Site 32
S392
P
G
G
S
G
S
D
S
N
N
T
G
E
Q
G
Site 33
S413
A
E
P
E
L
E
L
S
D
Y
P
W
F
H
G
Site 34
Y415
P
E
L
E
L
S
D
Y
P
W
F
H
G
T
L
Site 35
T421
D
Y
P
W
F
H
G
T
L
S
R
V
K
A
A
Site 36
S423
P
W
F
H
G
T
L
S
R
V
K
A
A
Q
L
Site 37
S447
G
L
F
V
I
R
Q
S
E
T
R
P
G
E
Y
Site 38
Y454
S
E
T
R
P
G
E
Y
V
L
T
F
N
F
Q
Site 39
T457
R
P
G
E
Y
V
L
T
F
N
F
Q
G
K
A
Site 40
S470
K
A
K
H
L
R
L
S
L
N
G
H
G
Q
C
Site 41
T496
D
M
L
R
H
F
H
T
H
P
I
P
L
E
S
Site 42
S506
I
P
L
E
S
G
G
S
A
D
I
T
L
R
S
Site 43
T510
S
G
G
S
A
D
I
T
L
R
S
Y
V
R
A
Site 44
S513
S
A
D
I
T
L
R
S
Y
V
R
A
Q
D
P
Site 45
Y514
A
D
I
T
L
R
S
Y
V
R
A
Q
D
P
P
Site 46
T527
P
P
P
E
P
G
P
T
P
P
A
A
P
A
S
Site 47
S534
T
P
P
A
A
P
A
S
P
A
C
W
S
D
S
Site 48
S539
P
A
S
P
A
C
W
S
D
S
P
G
Q
H
Y
Site 49
S541
S
P
A
C
W
S
D
S
P
G
Q
H
Y
F
S
Site 50
Y546
S
D
S
P
G
Q
H
Y
F
S
S
L
A
A
A
Site 51
S561
A
C
P
P
A
S
P
S
D
A
A
G
A
S
S
Site 52
S567
P
S
D
A
A
G
A
S
S
S
S
A
S
S
S
Site 53
S568
S
D
A
A
G
A
S
S
S
S
A
S
S
S
S
Site 54
S569
D
A
A
G
A
S
S
S
S
A
S
S
S
S
A
Site 55
S570
A
A
G
A
S
S
S
S
A
S
S
S
S
A
A
Site 56
S572
G
A
S
S
S
S
A
S
S
S
S
A
A
S
G
Site 57
S573
A
S
S
S
S
A
S
S
S
S
A
A
S
G
P
Site 58
S574
S
S
S
S
A
S
S
S
S
A
A
S
G
P
A
Site 59
S575
S
S
S
A
S
S
S
S
A
A
S
G
P
A
P
Site 60
S578
A
S
S
S
S
A
A
S
G
P
A
P
P
R
P
Site 61
S591
R
P
V
E
G
Q
L
S
A
R
S
R
S
N
S
Site 62
S594
E
G
Q
L
S
A
R
S
R
S
N
S
A
E
R
Site 63
S596
Q
L
S
A
R
S
R
S
N
S
A
E
R
L
L
Site 64
S598
S
A
R
S
R
S
N
S
A
E
R
L
L
E
A
Site 65
Y629
A
R
A
V
E
N
Q
Y
S
F
Y
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation