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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DRP1
Full Name:
Dynamin-1-like protein
Alias:
DNM1L; Dnm1p/Vps1p-like; DVLP; Dymple; Dynamin 1-like; Dynamin family member proline-rich carboxyl-terminal domain less; Dynamin-like; Dynamin-like 4; Dynamin-like IV; Dynamin-like protein; HDYNIV; VPS1
Type:
EC 3.6.5.5; Hydrolase; G protein; Apoptosis; Motor protein; Endoplasmic reticulum; Mitochondrial
Mass (Da):
81877
Number AA:
736
UniProt ID:
O00429
International Prot ID:
IPI00037283
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005801
GO:0005829
GO:0005783
Uniprot
OncoNet
Molecular Function:
GO:0005525
GO:0003924
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007154
GO:0043653
GO:0007006
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T33
P
Q
I
V
V
V
G
T
Q
S
S
G
K
S
S
Site 2
S39
G
T
Q
S
S
G
K
S
S
V
L
E
S
L
V
Site 3
S40
T
Q
S
S
G
K
S
S
V
L
E
S
L
V
G
Site 4
T55
R
D
L
L
P
R
G
T
G
I
V
T
R
R
P
Site 5
T59
P
R
G
T
G
I
V
T
R
R
P
L
I
L
Q
Site 6
T78
S
Q
E
D
K
R
K
T
T
G
E
E
N
G
V
Site 7
T79
Q
E
D
K
R
K
T
T
G
E
E
N
G
V
E
Site 8
Y101
L
H
T
K
N
K
L
Y
T
D
F
D
E
I
R
Site 9
T115
R
Q
E
I
E
N
E
T
E
R
I
S
G
N
N
Site 10
S119
E
N
E
T
E
R
I
S
G
N
N
K
G
V
S
Site 11
S126
S
G
N
N
K
G
V
S
P
E
P
I
H
L
K
Site 12
S179
R
F
I
S
N
P
N
S
I
I
L
A
V
T
A
Site 13
T193
A
A
N
T
D
M
A
T
S
E
A
L
K
I
S
Site 14
S194
A
N
T
D
M
A
T
S
E
A
L
K
I
S
R
Site 15
T210
V
D
P
D
G
R
R
T
L
A
V
I
T
K
L
Site 16
T215
R
R
T
L
A
V
I
T
K
L
D
L
M
D
A
Site 17
S248
I
I
G
V
V
N
R
S
Q
L
D
I
N
N
K
Site 18
S257
L
D
I
N
N
K
K
S
V
T
D
S
I
R
D
Site 19
S261
N
K
K
S
V
T
D
S
I
R
D
E
Y
A
F
Site 20
Y266
T
D
S
I
R
D
E
Y
A
F
L
Q
K
K
Y
Site 21
Y273
Y
A
F
L
Q
K
K
Y
P
S
L
A
N
R
N
Site 22
T282
S
L
A
N
R
N
G
T
K
Y
L
A
R
T
L
Site 23
Y284
A
N
R
N
G
T
K
Y
L
A
R
T
L
N
R
Site 24
T288
G
T
K
Y
L
A
R
T
L
N
R
L
L
M
H
Site 25
S317
V
L
A
A
Q
Y
Q
S
L
L
N
S
Y
G
E
Site 26
S321
Q
Y
Q
S
L
L
N
S
Y
G
E
P
V
D
D
Site 27
Y322
Y
Q
S
L
L
N
S
Y
G
E
P
V
D
D
K
Site 28
S330
G
E
P
V
D
D
K
S
A
T
L
L
Q
L
I
Site 29
Y344
I
T
K
F
A
T
E
Y
C
N
T
I
E
G
T
Site 30
T347
F
A
T
E
Y
C
N
T
I
E
G
T
A
K
Y
Site 31
Y354
T
I
E
G
T
A
K
Y
I
E
T
S
E
L
C
Site 32
S358
T
A
K
Y
I
E
T
S
E
L
C
G
G
A
R
Site 33
S428
I
K
R
L
E
E
P
S
L
R
C
V
E
L
V
Site 34
T451
Q
H
C
S
N
Y
S
T
Q
E
L
L
R
F
P
Site 35
T479
L
R
K
R
L
P
V
T
N
E
M
V
H
N
L
Site 36
S526
R
L
A
R
E
L
P
S
A
V
S
R
D
K
S
Site 37
S529
R
E
L
P
S
A
V
S
R
D
K
S
S
K
V
Site 38
S533
S
A
V
S
R
D
K
S
S
K
V
P
S
A
L
Site 39
S534
A
V
S
R
D
K
S
S
K
V
P
S
A
L
A
Site 40
S538
D
K
S
S
K
V
P
S
A
L
A
P
A
S
Q
Site 41
S544
P
S
A
L
A
P
A
S
Q
E
P
S
P
A
A
Site 42
S548
A
P
A
S
Q
E
P
S
P
A
A
S
A
E
A
Site 43
S552
Q
E
P
S
P
A
A
S
A
E
A
D
G
K
L
Site 44
S563
D
G
K
L
I
Q
D
S
R
R
E
T
K
N
V
Site 45
T567
I
Q
D
S
R
R
E
T
K
N
V
A
S
G
G
Site 46
T586
D
G
V
Q
E
P
T
T
G
N
W
R
G
M
L
Site 47
T595
N
W
R
G
M
L
K
T
S
K
A
E
E
L
L
Site 48
S596
W
R
G
M
L
K
T
S
K
A
E
E
L
L
A
Site 49
S607
E
L
L
A
E
E
K
S
K
P
I
P
I
M
P
Site 50
S616
P
I
P
I
M
P
A
S
P
Q
K
G
H
A
V
Site 51
S637
V
P
V
A
R
K
L
S
A
R
E
Q
R
D
C
Site 52
S665
V
R
K
N
I
Q
D
S
V
P
K
A
V
M
H
Site 53
T681
L
V
N
H
V
K
D
T
L
Q
S
E
L
V
G
Site 54
S684
H
V
K
D
T
L
Q
S
E
L
V
G
Q
L
Y
Site 55
Y691
S
E
L
V
G
Q
L
Y
K
S
S
L
L
D
D
Site 56
T701
S
L
L
D
D
L
L
T
E
S
E
D
M
A
Q
Site 57
S703
L
D
D
L
L
T
E
S
E
D
M
A
Q
R
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation