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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
BMPR1B
Full Name:
Bone morphogenetic protein receptor type-1B
Alias:
BMR1B; EC 2.7.11.30; Kinase ALK6
Type:
Membrane Protein
Mass (Da):
56930
Number AA:
502
UniProt ID:
O00238
International Prot ID:
IPI00010862
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
GO:0043235
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0046332
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0030509
GO:0001502
GO:0035108
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y150
I
L
F
C
Y
F
R
Y
K
R
Q
E
T
R
P
Site 2
T155
F
R
Y
K
R
Q
E
T
R
P
R
Y
S
I
G
Site 3
Y159
R
Q
E
T
R
P
R
Y
S
I
G
L
E
Q
D
Site 4
S160
Q
E
T
R
P
R
Y
S
I
G
L
E
Q
D
E
Site 5
T168
I
G
L
E
Q
D
E
T
Y
I
P
P
G
E
S
Site 6
Y169
G
L
E
Q
D
E
T
Y
I
P
P
G
E
S
L
Site 7
S175
T
Y
I
P
P
G
E
S
L
R
D
L
I
E
Q
Site 8
S183
L
R
D
L
I
E
Q
S
Q
S
S
G
S
G
S
Site 9
S185
D
L
I
E
Q
S
Q
S
S
G
S
G
S
G
L
Site 10
S186
L
I
E
Q
S
Q
S
S
G
S
G
S
G
L
P
Site 11
S188
E
Q
S
Q
S
S
G
S
G
S
G
L
P
L
L
Site 12
S190
S
Q
S
S
G
S
G
S
G
L
P
L
L
V
Q
Site 13
Y215
K
Q
I
G
K
G
R
Y
G
E
V
W
M
G
K
Site 14
T245
E
A
S
W
F
R
E
T
E
I
Y
Q
T
V
L
Site 15
Y248
W
F
R
E
T
E
I
Y
Q
T
V
L
M
R
H
Site 16
T250
R
E
T
E
I
Y
Q
T
V
L
M
R
H
E
N
Site 17
Y276
T
G
S
W
T
Q
L
Y
L
I
T
D
Y
H
E
Site 18
Y281
Q
L
Y
L
I
T
D
Y
H
E
N
G
S
L
Y
Site 19
S286
T
D
Y
H
E
N
G
S
L
Y
D
Y
L
K
S
Site 20
Y288
Y
H
E
N
G
S
L
Y
D
Y
L
K
S
T
T
Site 21
Y290
E
N
G
S
L
Y
D
Y
L
K
S
T
T
L
D
Site 22
S293
S
L
Y
D
Y
L
K
S
T
T
L
D
A
K
S
Site 23
T295
Y
D
Y
L
K
S
T
T
L
D
A
K
S
M
L
Site 24
S300
S
T
T
L
D
A
K
S
M
L
K
L
A
Y
S
Site 25
T317
S
G
L
C
H
L
H
T
E
I
F
S
T
Q
G
Site 26
T322
L
H
T
E
I
F
S
T
Q
G
K
P
A
I
A
Site 27
S335
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
Site 28
T361
A
V
K
F
I
S
D
T
N
E
V
D
I
P
P
Site 29
T370
E
V
D
I
P
P
N
T
R
V
G
T
K
R
Y
Site 30
T374
P
P
N
T
R
V
G
T
K
R
Y
M
P
P
E
Site 31
Y377
T
R
V
G
T
K
R
Y
M
P
P
E
V
L
D
Site 32
S386
P
P
E
V
L
D
E
S
L
N
R
N
H
F
Q
Site 33
S402
Y
I
M
A
D
M
Y
S
F
G
L
I
L
W
E
Site 34
S416
E
V
A
R
R
C
V
S
G
G
I
V
E
E
Y
Site 35
Y423
S
G
G
I
V
E
E
Y
Q
L
P
Y
H
D
L
Site 36
Y427
V
E
E
Y
Q
L
P
Y
H
D
L
V
P
S
D
Site 37
S433
P
Y
H
D
L
V
P
S
D
P
S
Y
E
D
M
Site 38
S436
D
L
V
P
S
D
P
S
Y
E
D
M
R
E
I
Site 39
Y437
L
V
P
S
D
P
S
Y
E
D
M
R
E
I
V
Site 40
S452
C
I
K
K
L
R
P
S
F
P
N
R
W
S
S
Site 41
S458
P
S
F
P
N
R
W
S
S
D
E
C
L
R
Q
Site 42
S459
S
F
P
N
R
W
S
S
D
E
C
L
R
Q
M
Site 43
T483
H
N
P
A
S
R
L
T
A
L
R
V
K
K
T
Site 44
T490
T
A
L
R
V
K
K
T
L
A
K
M
S
E
S
Site 45
S497
T
L
A
K
M
S
E
S
Q
D
I
K
L
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation