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Updated November 2019
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Protein Info
Short Name:
RGPD3
Full Name:
RanBP2-like and GRIP domain-containing protein 3
Alias:
RANBP2-like and GRIP domain containing 3; RGP3
Type:
Uncharacterized protein
Mass (Da):
198394
Number AA:
1766
UniProt ID:
A6NKT7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0046907
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y11
S
K
A
Y
G
E
R
Y
V
A
S
V
Q
G
S
Site 2
S14
Y
G
E
R
Y
V
A
S
V
Q
G
S
A
P
S
Site 3
S18
Y
V
A
S
V
Q
G
S
A
P
S
P
R
K
K
Site 4
S21
S
V
Q
G
S
A
P
S
P
R
K
K
S
T
R
Site 5
S26
A
P
S
P
R
K
K
S
T
R
G
F
Y
F
A
Site 6
Y31
K
K
S
T
R
G
F
Y
F
A
K
L
Y
Y
E
Site 7
Y36
G
F
Y
F
A
K
L
Y
Y
E
A
K
E
Y
D
Site 8
Y37
F
Y
F
A
K
L
Y
Y
E
A
K
E
Y
D
L
Site 9
Y42
L
Y
Y
E
A
K
E
Y
D
L
A
K
K
Y
I
Site 10
Y48
E
Y
D
L
A
K
K
Y
I
C
T
Y
I
N
V
Site 11
Y52
A
K
K
Y
I
C
T
Y
I
N
V
R
E
M
D
Site 12
Y70
H
R
F
L
G
L
L
Y
E
L
E
E
N
T
E
Site 13
S86
A
V
E
C
Y
R
R
S
V
E
L
N
P
T
Q
Site 14
T92
R
S
V
E
L
N
P
T
Q
K
D
L
V
L
K
Site 15
Y116
V
T
D
G
R
A
E
Y
W
V
E
R
A
A
K
Site 16
S128
A
A
K
L
F
P
G
S
P
A
I
Y
K
L
K
Site 17
Y132
F
P
G
S
P
A
I
Y
K
L
K
E
Q
L
L
Site 18
Y159
D
L
I
Q
S
E
L
Y
V
R
P
D
D
V
H
Site 19
Y175
N
I
R
L
V
E
L
Y
R
S
T
K
R
L
K
Site 20
S177
R
L
V
E
L
Y
R
S
T
K
R
L
K
D
A
Site 21
T178
L
V
E
L
Y
R
S
T
K
R
L
K
D
A
V
Site 22
S199
E
R
N
I
A
L
R
S
S
L
E
W
N
S
C
Site 23
S200
R
N
I
A
L
R
S
S
L
E
W
N
S
C
V
Site 24
S205
R
S
S
L
E
W
N
S
C
V
V
Q
T
L
K
Site 25
S217
T
L
K
E
Y
L
E
S
L
Q
C
L
E
S
D
Site 26
S223
E
S
L
Q
C
L
E
S
D
K
S
D
W
R
A
Site 27
S226
Q
C
L
E
S
D
K
S
D
W
R
A
T
N
T
Site 28
T231
D
K
S
D
W
R
A
T
N
T
D
L
L
L
A
Site 29
S248
N
L
M
L
L
T
L
S
T
R
D
V
Q
E
S
Site 30
S255
S
T
R
D
V
Q
E
S
R
E
L
L
E
S
F
Site 31
S261
E
S
R
E
L
L
E
S
F
D
S
A
L
Q
S
Site 32
S264
E
L
L
E
S
F
D
S
A
L
Q
S
A
K
S
Site 33
S268
S
F
D
S
A
L
Q
S
A
K
S
S
L
G
G
Site 34
S271
S
A
L
Q
S
A
K
S
S
L
G
G
N
D
E
Site 35
S272
A
L
Q
S
A
K
S
S
L
G
G
N
D
E
L
Site 36
S280
L
G
G
N
D
E
L
S
A
T
F
L
E
M
K
Site 37
T282
G
N
D
E
L
S
A
T
F
L
E
M
K
G
H
Site 38
S353
M
M
A
C
D
R
L
S
Q
S
G
H
M
L
L
Site 39
S355
A
C
D
R
L
S
Q
S
G
H
M
L
L
N
L
Site 40
S363
G
H
M
L
L
N
L
S
R
G
K
Q
D
F
L
Site 41
S381
V
E
T
F
A
N
K
S
G
Q
S
A
L
Y
D
Site 42
Y387
K
S
G
Q
S
A
L
Y
D
A
L
F
S
S
Q
Site 43
S393
L
Y
D
A
L
F
S
S
Q
S
P
K
D
T
S
Site 44
S395
D
A
L
F
S
S
Q
S
P
K
D
T
S
F
L
Site 45
T399
S
S
Q
S
P
K
D
T
S
F
L
G
S
D
D
Site 46
S400
S
Q
S
P
K
D
T
S
F
L
G
S
D
D
I
Site 47
S404
K
D
T
S
F
L
G
S
D
D
I
G
N
I
D
Site 48
S434
A
I
R
A
H
N
G
S
L
Q
H
L
T
W
L
Site 49
T474
Q
E
T
S
R
L
E
T
N
A
P
E
S
I
C
Site 50
S506
Q
L
K
E
K
C
N
S
H
H
S
S
Y
Q
P
Site 51
S588
K
C
L
Q
K
M
G
S
G
L
N
S
F
Y
D
Site 52
S592
K
M
G
S
G
L
N
S
F
Y
D
Q
R
E
Y
Site 53
Y594
G
S
G
L
N
S
F
Y
D
Q
R
E
Y
I
G
Site 54
Y599
S
F
Y
D
Q
R
E
Y
I
G
R
S
V
H
Y
Site 55
Y606
Y
I
G
R
S
V
H
Y
W
K
K
V
L
P
L
Site 56
Y647
Q
A
S
E
I
V
E
Y
E
E
D
A
H
V
T
Site 57
T670
G
N
I
E
D
A
M
T
A
F
E
S
I
K
S
Site 58
S701
D
I
A
N
D
A
L
S
P
E
E
Q
E
E
C
Site 59
Y711
E
Q
E
E
C
K
N
Y
L
R
K
T
R
G
Y
Site 60
T715
C
K
N
Y
L
R
K
T
R
G
Y
L
I
K
I
Site 61
Y718
Y
L
R
K
T
R
G
Y
L
I
K
I
L
D
D
Site 62
S728
K
I
L
D
D
S
D
S
N
L
S
V
V
K
K
Site 63
S731
D
D
S
D
S
N
L
S
V
V
K
K
L
P
V
Site 64
S742
K
L
P
V
P
L
E
S
V
K
E
M
L
K
S
Site 65
S749
S
V
K
E
M
L
K
S
V
M
Q
E
L
E
N
Site 66
Y757
V
M
Q
E
L
E
N
Y
S
E
G
G
P
L
Y
Site 67
Y764
Y
S
E
G
G
P
L
Y
K
N
G
S
L
R
N
Site 68
S768
G
P
L
Y
K
N
G
S
L
R
N
A
D
S
E
Site 69
S774
G
S
L
R
N
A
D
S
E
I
K
H
S
T
P
Site 70
S779
A
D
S
E
I
K
H
S
T
P
S
P
T
K
Y
Site 71
T780
D
S
E
I
K
H
S
T
P
S
P
T
K
Y
S
Site 72
S782
E
I
K
H
S
T
P
S
P
T
K
Y
S
L
S
Site 73
T784
K
H
S
T
P
S
P
T
K
Y
S
L
S
P
S
Site 74
Y786
S
T
P
S
P
T
K
Y
S
L
S
P
S
K
S
Site 75
S787
T
P
S
P
T
K
Y
S
L
S
P
S
K
S
Y
Site 76
S789
S
P
T
K
Y
S
L
S
P
S
K
S
Y
K
Y
Site 77
S791
T
K
Y
S
L
S
P
S
K
S
Y
K
Y
S
P
Site 78
S793
Y
S
L
S
P
S
K
S
Y
K
Y
S
P
K
T
Site 79
Y796
S
P
S
K
S
Y
K
Y
S
P
K
T
P
P
R
Site 80
S797
P
S
K
S
Y
K
Y
S
P
K
T
P
P
R
W
Site 81
T800
S
Y
K
Y
S
P
K
T
P
P
R
W
A
E
D
Site 82
S810
R
W
A
E
D
Q
N
S
L
L
K
M
I
R
Q
Site 83
S833
M
Q
E
L
K
L
N
S
S
K
S
A
S
H
H
Site 84
S834
Q
E
L
K
L
N
S
S
K
S
A
S
H
H
R
Site 85
S836
L
K
L
N
S
S
K
S
A
S
H
H
R
W
P
Site 86
S838
L
N
S
S
K
S
A
S
H
H
R
W
P
T
E
Site 87
T844
A
S
H
H
R
W
P
T
E
N
Y
G
P
D
S
Site 88
Y847
H
R
W
P
T
E
N
Y
G
P
D
S
V
P
D
Site 89
S851
T
E
N
Y
G
P
D
S
V
P
D
G
Y
Q
G
Site 90
Y856
P
D
S
V
P
D
G
Y
Q
G
S
Q
T
F
H
Site 91
S859
V
P
D
G
Y
Q
G
S
Q
T
F
H
G
A
P
Site 92
T861
D
G
Y
Q
G
S
Q
T
F
H
G
A
P
L
T
Site 93
S875
T
V
A
T
T
G
P
S
V
Y
Y
S
Q
S
P
Site 94
Y877
A
T
T
G
P
S
V
Y
Y
S
Q
S
P
A
Y
Site 95
S879
T
G
P
S
V
Y
Y
S
Q
S
P
A
Y
N
S
Site 96
S881
P
S
V
Y
Y
S
Q
S
P
A
Y
N
S
Q
Y
Site 97
Y884
Y
Y
S
Q
S
P
A
Y
N
S
Q
Y
L
L
R
Site 98
S886
S
Q
S
P
A
Y
N
S
Q
Y
L
L
R
P
A
Site 99
Y888
S
P
A
Y
N
S
Q
Y
L
L
R
P
A
A
N
Site 100
T897
L
R
P
A
A
N
V
T
P
T
K
G
S
S
N
Site 101
T905
P
T
K
G
S
S
N
T
E
F
K
S
T
K
E
Site 102
S909
S
S
N
T
E
F
K
S
T
K
E
G
F
S
I
Site 103
T910
S
N
T
E
F
K
S
T
K
E
G
F
S
I
P
Site 104
S915
K
S
T
K
E
G
F
S
I
P
V
S
A
D
G
Site 105
S928
D
G
F
K
F
G
I
S
E
P
G
N
Q
E
K
Site 106
S937
P
G
N
Q
E
K
K
S
E
K
P
L
E
N
D
Site 107
S953
G
L
Q
A
Q
D
I
S
G
R
K
K
G
R
G
Site 108
T971
G
Q
T
S
S
T
F
T
F
A
D
V
A
K
S
Site 109
S978
T
F
A
D
V
A
K
S
T
S
G
E
G
F
Q
Site 110
T979
F
A
D
V
A
K
S
T
S
G
E
G
F
Q
F
Site 111
S980
A
D
V
A
K
S
T
S
G
E
G
F
Q
F
G
Site 112
S1005
G
A
G
E
K
L
F
S
S
Q
Y
G
K
M
A
Site 113
S1006
A
G
E
K
L
F
S
S
Q
Y
G
K
M
A
N
Site 114
Y1008
E
K
L
F
S
S
Q
Y
G
K
M
A
N
K
A
Site 115
S1018
M
A
N
K
A
N
T
S
G
D
F
E
K
D
D
Site 116
Y1028
F
E
K
D
D
D
A
Y
K
T
E
D
S
D
D
Site 117
T1030
K
D
D
D
A
Y
K
T
E
D
S
D
D
I
H
Site 118
S1033
D
A
Y
K
T
E
D
S
D
D
I
H
F
E
P
Site 119
Y1061
E
E
G
E
K
V
L
Y
S
Q
G
V
K
L
F
Site 120
S1062
E
G
E
K
V
L
Y
S
Q
G
V
K
L
F
R
Site 121
S1075
F
R
F
D
A
E
V
S
Q
W
K
E
R
G
L
Site 122
S1124
T
M
N
L
K
P
L
S
G
S
D
R
A
W
M
Site 123
S1126
N
L
K
P
L
S
G
S
D
R
A
W
M
W
S
Site 124
S1133
S
D
R
A
W
M
W
S
A
S
D
F
S
D
G
Site 125
S1135
R
A
W
M
W
S
A
S
D
F
S
D
G
D
A
Site 126
T1153
R
L
A
A
K
F
K
T
P
E
L
A
E
E
F
Site 127
T1178
L
L
D
I
P
L
Q
T
P
H
K
L
V
D
T
Site 128
T1185
T
P
H
K
L
V
D
T
G
R
A
A
K
L
I
Site 129
S1200
Q
R
A
E
E
M
K
S
G
L
K
D
F
K
T
Site 130
T1207
S
G
L
K
D
F
K
T
F
L
T
N
D
Q
T
Site 131
T1214
T
F
L
T
N
D
Q
T
K
V
A
E
E
E
N
Site 132
S1224
A
E
E
E
N
K
G
S
G
T
G
A
A
G
A
Site 133
T1235
A
A
G
A
S
D
T
T
I
K
P
N
A
E
N
Site 134
Y1252
P
T
L
E
W
D
N
Y
D
L
R
E
D
A
L
Site 135
S1262
R
E
D
A
L
D
D
S
V
S
S
S
S
V
H
Site 136
S1264
D
A
L
D
D
S
V
S
S
S
S
V
H
A
S
Site 137
S1265
A
L
D
D
S
V
S
S
S
S
V
H
A
S
P
Site 138
S1266
L
D
D
S
V
S
S
S
S
V
H
A
S
P
L
Site 139
S1267
D
D
S
V
S
S
S
S
V
H
A
S
P
L
A
Site 140
S1271
S
S
S
S
V
H
A
S
P
L
A
S
S
P
V
Site 141
S1275
V
H
A
S
P
L
A
S
S
P
V
R
K
N
L
Site 142
S1276
H
A
S
P
L
A
S
S
P
V
R
K
N
L
F
Site 143
S1288
N
L
F
H
F
D
E
S
T
T
G
S
N
F
S
Site 144
T1289
L
F
H
F
D
E
S
T
T
G
S
N
F
S
F
Site 145
S1292
F
D
E
S
T
T
G
S
N
F
S
F
K
S
A
Site 146
S1295
S
T
T
G
S
N
F
S
F
K
S
A
L
S
L
Site 147
S1298
G
S
N
F
S
F
K
S
A
L
S
L
S
K
S
Site 148
S1301
F
S
F
K
S
A
L
S
L
S
K
S
P
A
K
Site 149
S1303
F
K
S
A
L
S
L
S
K
S
P
A
K
L
N
Site 150
S1305
S
A
L
S
L
S
K
S
P
A
K
L
N
Q
S
Site 151
S1312
S
P
A
K
L
N
Q
S
G
T
S
V
G
T
D
Site 152
T1314
A
K
L
N
Q
S
G
T
S
V
G
T
D
E
E
Site 153
S1315
K
L
N
Q
S
G
T
S
V
G
T
D
E
E
S
Site 154
T1318
Q
S
G
T
S
V
G
T
D
E
E
S
D
V
T
Site 155
S1322
S
V
G
T
D
E
E
S
D
V
T
Q
E
E
E
Site 156
T1325
T
D
E
E
S
D
V
T
Q
E
E
E
R
D
G
Site 157
Y1334
E
E
E
R
D
G
Q
Y
F
E
P
V
V
P
L
Site 158
S1349
P
D
L
V
E
V
S
S
G
E
E
N
E
Q
V
Site 159
Y1367
H
R
A
E
F
Y
R
Y
D
K
D
V
G
Q
W
Site 160
Y1388
D
I
K
I
L
Q
N
Y
D
N
K
H
V
R
I
Site 161
T1412
L
C
A
N
H
R
I
T
P
D
M
S
L
Q
N
Site 162
S1416
H
R
I
T
P
D
M
S
L
Q
N
M
K
G
T
Site 163
T1423
S
L
Q
N
M
K
G
T
E
R
V
W
V
W
T
Site 164
S1456
K
L
Q
D
V
A
D
S
F
K
K
I
F
D
E
Site 165
S1472
K
T
A
Q
E
K
D
S
L
I
T
P
H
V
S
Site 166
T1475
Q
E
K
D
S
L
I
T
P
H
V
S
R
S
S
Site 167
S1479
S
L
I
T
P
H
V
S
R
S
S
T
P
R
E
Site 168
S1481
I
T
P
H
V
S
R
S
S
T
P
R
E
S
P
Site 169
S1482
T
P
H
V
S
R
S
S
T
P
R
E
S
P
C
Site 170
T1483
P
H
V
S
R
S
S
T
P
R
E
S
P
C
G
Site 171
S1487
R
S
S
T
P
R
E
S
P
C
G
K
I
A
V
Site 172
T1500
A
V
A
V
L
E
E
T
T
R
E
R
T
D
V
Site 173
T1505
E
E
T
T
R
E
R
T
D
V
I
Q
G
D
D
Site 174
S1518
D
D
V
A
D
A
A
S
E
V
E
V
S
S
T
Site 175
S1523
A
A
S
E
V
E
V
S
S
T
S
E
T
T
T
Site 176
T1525
S
E
V
E
V
S
S
T
S
E
T
T
T
K
A
Site 177
S1526
E
V
E
V
S
S
T
S
E
T
T
T
K
A
V
Site 178
T1528
E
V
S
S
T
S
E
T
T
T
K
A
V
V
S
Site 179
T1529
V
S
S
T
S
E
T
T
T
K
A
V
V
S
P
Site 180
T1530
S
S
T
S
E
T
T
T
K
A
V
V
S
P
P
Site 181
S1535
T
T
T
K
A
V
V
S
P
P
K
F
V
F
G
Site 182
S1543
P
P
K
F
V
F
G
S
E
S
V
K
R
I
F
Site 183
S1545
K
F
V
F
G
S
E
S
V
K
R
I
F
S
S
Site 184
S1551
E
S
V
K
R
I
F
S
S
E
K
S
K
P
F
Site 185
S1552
S
V
K
R
I
F
S
S
E
K
S
K
P
F
A
Site 186
S1555
R
I
F
S
S
E
K
S
K
P
F
A
F
G
N
Site 187
S1568
G
N
S
S
A
T
G
S
L
F
G
F
S
F
N
Site 188
S1573
T
G
S
L
F
G
F
S
F
N
A
P
L
K
S
Site 189
S1580
S
F
N
A
P
L
K
S
N
N
S
E
T
S
S
Site 190
S1583
A
P
L
K
S
N
N
S
E
T
S
S
V
A
Q
Site 191
T1585
L
K
S
N
N
S
E
T
S
S
V
A
Q
S
G
Site 192
S1587
S
N
N
S
E
T
S
S
V
A
Q
S
G
S
E
Site 193
S1591
E
T
S
S
V
A
Q
S
G
S
E
S
K
V
E
Site 194
S1593
S
S
V
A
Q
S
G
S
E
S
K
V
E
P
K
Site 195
S1595
V
A
Q
S
G
S
E
S
K
V
E
P
K
K
C
Site 196
S1605
E
P
K
K
C
E
L
S
K
N
S
D
I
E
Q
Site 197
S1608
K
C
E
L
S
K
N
S
D
I
E
Q
S
S
D
Site 198
S1614
N
S
D
I
E
Q
S
S
D
S
K
V
K
N
L
Site 199
S1616
D
I
E
Q
S
S
D
S
K
V
K
N
L
S
A
Site 200
S1622
D
S
K
V
K
N
L
S
A
S
F
P
T
E
E
Site 201
S1624
K
V
K
N
L
S
A
S
F
P
T
E
E
S
S
Site 202
Y1634
T
E
E
S
S
I
N
Y
T
F
K
T
P
E
K
Site 203
T1635
E
E
S
S
I
N
Y
T
F
K
T
P
E
K
E
Site 204
T1638
S
I
N
Y
T
F
K
T
P
E
K
E
P
P
L
Site 205
S1660
E
E
L
V
Q
K
L
S
S
T
T
K
S
A
D
Site 206
S1661
E
L
V
Q
K
L
S
S
T
T
K
S
A
D
H
Site 207
S1665
K
L
S
S
T
T
K
S
A
D
H
L
N
G
L
Site 208
S1692
E
Q
I
K
L
L
K
S
E
I
R
R
L
E
R
Site 209
S1706
R
N
Q
E
Q
E
V
S
A
A
N
V
E
H
L
Site 210
S1727
F
I
F
L
K
P
G
S
E
R
E
R
L
L
P
Site 211
S1743
I
N
T
M
L
Q
L
S
L
E
E
K
G
K
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation