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Protein Info
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Short Name:
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CREB
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Full Name:
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Cyclic AMP-responsive element-binding protein 1
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Alias:
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CAMP responsive element binding protein 1; CAMP-response element binding protein; CREB1; CREB-1
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Type:
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Transcription protein
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Mass (Da):
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36688
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Number AA:
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341
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UniProt ID:
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P16220
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International Prot ID:
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IPI00027713
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Sequence:
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Retrieve full protein sequence
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GO Terms
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External Links
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Internal Links
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Cellular Component:
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GO:0005634
GO:0005654
GO:0043226
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Uniprot
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OncoNet
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Molecular Function:
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GO:0046983
GO:0043565
GO:0003712
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PhosphoSite+
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KinaseNET
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Biological Process:
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GO:0044419
GO:0006468
GO:0010033
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Phosida
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TranscriptoNet
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STRING
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Kinexus Products
cAMP-response element-binding protein 1 S133 phosphosite-specific antibody AB-PN553#https://kinexus-ca.myshopify.com/products/AB-PN553#cyclic-AMP response element binding protein-1 (K123-R135, human) peptide - Powder PE-01ACP95#https://kinexus-ca.myshopify.com/products/PE-01ACP95#cyclic-AMP response element binding protein-1 (K123-R135, human) peptide - Powder PE-03AAF90#https://kinexus-ca.myshopify.com/products/PE-03AAF90#Cyclic AMP-responsive element-binding protein 1 (K83-R95, pS93, human) pS93 biotinylated phosphopeptide - Powder PE-03AAH95#https://kinexus-ca.myshopify.com/products/PE-03AAH95#Cyclic AMP-responsive element-binding protein 1 (K83-R95, human) pS89+pS93 biotinylated phosphopeptide - Powder PE-03AAJ95#https://kinexus-ca.myshopify.com/products/PE-03AAJ95#cAMP-response element-binding protein 1 (R130-K136, human) pS133 phosphopeptide - Powder PE-04ARE90#https://kinexus-ca.myshopify.com/products/PE-04ARE90
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Info Box
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A variety of parameters were considered in the selection of putative P-sites.
Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score
is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr
or P-Tyr sites. The Maximum KInase Score provides the calculated score for
highest match of 500 human protein kinases for the amino acid sequence
surrounding the target P-site as determined with Kinase Substrate Predictor V2.
The Sum KInase Score provides the additive sum of the positive individual Kinase
Substrate Predictor V2 scores from 500 human protein kinases. The Conservation
Score is the average of the percent similarity of the human P-site with the
equivalent P-site in 20 other diverse species. Click the coloured buttons below
to retrieve this and other information in the Info Box, or click the orange
buttons for relevant links. |
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| Phosphosites | |
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| | | -7 | -6 | -5 | -4 | -3 | -2 | -1 | 0 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | | Expt. conf. | Effect | Kinase | PPase | Kinexus Products | | Ref. | Evol. | Kinase Pred. | P-site Match |
| | Site 1 | S12 | S | G | A | E | N | Q | Q | S | G | D | A | A | V | T | E | |  |  | | | | | |  | | |
| | Site 2 | S80 | A | Q | P | S | V | I | Q | S | P | Q | V | Q | T | V | Q | | | | | | | | | | | |
| | Site 3 | T85 | I | Q | S | P | Q | V | Q | T | V | Q | S | S | C | K | D | | | | | | | | | | | |
| | Site 4 | S98 | K | D | L | K | R | L | F | S | G | T | Q | I | S | T | I | |  | | | | | | | | | |
| | Site 5 | T100 | L | K | R | L | F | S | G | T | Q | I | S | T | I | A | E | | | | | | | | | | | |
| | Site 6 | S103 | L | F | S | G | T | Q | I | S | T | I | A | E | S | E | D | | | | | | | | | | | |
| | Site 7 | S108 | Q | I | S | T | I | A | E | S | E | D | S | Q | E | S | V | | | | | | | | | | | |
| | Site 8 | S111 | T | I | A | E | S | E | D | S | Q | E | S | V | D | S | V | | | | | | | | | | | |
| | Site 9 | S114 | E | S | E | D | S | Q | E | S | V | D | S | V | T | D | S | | | | | | | | | | | |
| | Site 10 | S117 | D | S | Q | E | S | V | D | S | V | T | D | S | Q | K | R | | | | | | | | | | | |
| | Site 11 | T119 | Q | E | S | V | D | S | V | T | D | S | Q | K | R | R | E | | | | | | | | | | | |
| | Site 12 | S121 | S | V | D | S | V | T | D | S | Q | K | R | R | E | I | L | | | | | | | | | | | |
| | Site 13 | S129 | Q | K | R | R | E | I | L | S | R | R | P | S | Y | R | K | | | | | |  cAMP-response element-binding protein 1 (CREB1) [E126-K136, human] S129 phosphosite-specific antibody AB-PN577#https://kinexus-ca.myshopify.com/products/AB-PN577 | | | | | |
| | Site 14 | S133 | E | I | L | S | R | R | P | S | Y | R | K | I | L | N | D | | | | | | cAMP-response element-binding protein 1 (CREB1) [E126-K136, human] S133 phosphosite-specific antibody AB-PN577#https://kinexus-ca.myshopify.com/products/AB-PN577 | | | | | |
| | Site 15 | Y134 | I | L | S | R | R | P | S | Y | R | K | I | L | N | D | L | | | | | | | | | | | |
| | Site 16 | S142 | R | K | I | L | N | D | L | S | S | D | A | P | G | V | P | | | | | | | | | | | |
| | Site 17 | S143 | K | I | L | N | D | L | S | S | D | A | P | G | V | P | R | | | | | | | | | | | |
| | Site 18 | S156 | P | R | I | E | E | E | K | S | E | E | E | T | S | A | P | | | | | | | | | | | |
| | Site 19 | S161 | E | K | S | E | E | E | T | S | A | P | A | I | T | T | V | | | | | | | | | | | |
| | Site 20 | Y175 | V | T | V | P | T | P | I | Y | Q | T | S | S | G | Q | Y | | | | | | | | | | | |
| | Site 21 | Y182 | Y | Q | T | S | S | G | Q | Y | I | A | I | T | Q | G | G | | | | | | | | | | | |
| | Site 22 | T206 | D | G | V | Q | G | L | Q | T | L | T | M | T | N | A | A | | | | | | | | | | | |
| | Site 23 | Y224 | P | G | T | T | I | L | Q | Y | A | Q | T | T | D | G | Q | | | | | | | | | | | |
| | Site 24 | S270 | A | P | G | V | V | M | A | S | S | P | A | L | P | T | Q | | | | | | | | | | | |
| | Site 25 | S271 | P | G | V | V | M | A | S | S | P | A | L | P | T | Q | P | | | | | | | | | | | |
| | Site 26 | Y307 | C | R | R | K | K | K | E | Y | V | K | C | L | E | N | R | | | | | | | | | | | |
| | Site 27 | Y336 | L | K | A | L | K | D | L | Y | C | H | K | S | D | _ | _ | | | | | | | | | | | |
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Legend
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Confirmed in mammals
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Confirmed in related proteins or other species
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Predicted by Kinexus P-Site Prediction algorithm
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No data/link available
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Link available
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Products available
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2019 Kinexus Bioinformatics Corporation
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